Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stefania Di Cio"'
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Microfabricated organ-on-a-chips are rapidly becoming the gold standard for the testing of safety and efficacy of therapeutics. A broad range of designs has emerged, but recreating microvascularised tissue models remains difficult in many ca
Externí odkaz:
https://doaj.org/article/e389f9a68ca5476bb645cfadc3c071bb
Autor:
Alice Scemama, Sophia Lunetto, Adrian Biddle, Matthew Dibble, Julien Gautrot, Artysha Tailor, Stefania Di Cio
Publikováno v:
F1000Research, Vol 12 (2024)
Metastasis occurs when cancer cells leave the primary tumour and travel to a secondary site to form a new lesion. The tumour microenvironment (TME) is recognised to greatly influence this process, with for instance the vascular system enabling the di
Externí odkaz:
https://doaj.org/article/125256cb34a641efa2199e40c2bce979
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Recapitulating the normal physiology of the microvasculature is pivotal in the development of more complex in-vitro models and organ-on-chip designs. Pericytes are an important component of the vasculature, promoting vessel stability, inhibi
Externí odkaz:
https://doaj.org/article/f0fc5020034345f5bdddfcf09c87d820
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 10 (2022)
Tissue-engineered skin constructs have been under development since the 1980s as a replacement for human skin tissues and animal models for therapeutics and cosmetic testing. These have evolved from simple single-cell assays to increasingly complex m
Externí odkaz:
https://doaj.org/article/b63406aeb52041aea0f19094f883ffa1
Autor:
Atiya M. Sarmin, Nadia El Moussaid, Ratima Suntornnond, Eleanor J. Tyler, Yang-Hee Kim, Stefania Di Cio, William V. Megone, Oliver Pearce, Julien E. Gautrot, Jonathan Dawson, John T. Connelly
Publikováno v:
Biomolecules, Vol 12, Iss 6, p 837 (2022)
The extracellular matrix (ECM) is a complex mixture of structural proteins, proteoglycans, and signaling molecules that are essential for tissue integrity and homeostasis. While a number of recent studies have explored the use of decellularized ECM (
Externí odkaz:
https://doaj.org/article/8cb50e48df024102aa910c73c6481901
Recapitulating the normal physiology of the microvasculature is pivotal in the development of more complex in vitro models and organ-on-chip design. Pericytes are an important component of the vasculature, promoting vessel stability, inhibiting vascu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::944fe802eafef4f7a8776b3ce0645a97
https://doi.org/10.1101/2022.05.03.490457
https://doi.org/10.1101/2022.05.03.490457
Publikováno v:
Biomacromolecules. 21(12)
Dynamic photoresponsive synthetic hydrogels offer important advantages for biomaterials design, from the ability to cure hydrogels and encapsulate cells in situ to the light-mediated control of cell-spreading and tissue formation. We report the facil
Publikováno v:
Biomaterials
The nanotopography and nanoscale geometry of the extra-cellular matrix (ECM) are important regulators of cell adhesion, motility and fate decision. However, unlike the sensing of matrix mechanics and ECM density, the molecular processes regulating th
Autor:
Julien E. Gautrot, Stefania Di Cio
Publikováno v:
Acta Biomaterialia. 30:26-48
The chemistry, geometry, topography and mechanical properties of biomaterials modulate biochemical signals (in particular ligand-receptor binding events) that control cells-matrix interactions. In turn, the regulation of cell adhesion by the biochemi
Publikováno v:
ACS nano. 12(9)
The culture of adherent cells is overwhelmingly relying on the use of solid substrates to support cell adhesion. Indeed, it is typically thought that relatively strong bulk mechanical properties (bulk moduli in the range of kPa to GPa) are essential