Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Stefania Crotta"'
Autor:
Stefania Crotta, Matteo Villa, Jack Major, Katja Finsterbusch, Miriam Llorian, Peter Carmeliet, Joerg Buescher, Andreas Wack
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Airway epithelial repair, a key process in the recovery from lung injury, requires a metabolic shift from glycolysis to fatty acid oxidation (FAO). Pharmacological FAO promotion enhances epithelial differentiation, suggesting new therapeutic options.
Externí odkaz:
https://doaj.org/article/0f17e6d006a2459fafee9429aa641663
Autor:
Peter A C Wing, Maria Prange-Barczynska, Amy Cross, Stefania Crotta, Claudia Orbegozo Rubio, Xiaotong Cheng, James M Harris, Xiaodong Zhuang, Rachel L Johnson, Kathryn A Ryan, Yper Hall, Miles W Carroll, Fadi Issa, Peter Balfe, Andreas Wack, Tammie Bishop, Francisco J Salguero, Jane A McKeating
Publikováno v:
PLoS Pathogens, Vol 18, Iss 9, p e1010807 (2022)
Understanding the host pathways that define susceptibility to Severe-acute-respiratory-syndrome-coronavirus-2 (SARS-CoV-2) infection and disease are essential for the design of new therapies. Oxygen levels in the microenvironment define the transcrip
Externí odkaz:
https://doaj.org/article/3c410b7e7d0e4ff392b4c3a2e70b9525
Autor:
Jacob Thyrsted, Jacob Storgaard, Julia Blay-Cadanet, Alexander Heinz, Anne Laugaard Thielke, Stefania Crotta, Frank de Paoli, David Olagnier, Andreas Wack, Karsten Hiller, Anne Louise Hansen, Christian Kanstrup Holm
Publikováno v:
iScience, Vol 24, Iss 11, Pp 103300- (2021)
Summary: Pathogenic viruses induce metabolic changes in host cells to secure the availability of biomolecules and energy to propagate. Influenza A virus (IAV) and severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) both infect the human air
Externí odkaz:
https://doaj.org/article/4026fa2356d24d3aa8b17fca2a42d3f0
Autor:
Daniel Schnepf, Pedro Hernandez, Tanel Mahlakõiv, Stefania Crotta, Meagan E Sullender, Stefan T Peterson, Annette Ohnemus, Camille Michiels, Ian Gentle, Laure Dumoutier, Celso A Reis, Andreas Diefenbach, Andreas Wack, Megan T Baldridge, Peter Staeheli
Publikováno v:
PLoS ONE, Vol 16, Iss 8, p e0247738 (2021)
The commensal microbiota regulates susceptibility to enteric pathogens by fine-tuning mucosal innate immune responses, but how susceptibility to enteric viruses is shaped by the microbiota remains incompletely understood. Past reports have indicated
Externí odkaz:
https://doaj.org/article/d68b02450db24632b3ba2774fe30dfac
Autor:
Konrad C. Bradley, Katja Finsterbusch, Daniel Schnepf, Stefania Crotta, Miriam Llorian, Sophia Davidson, Serge Y. Fuchs, Peter Staeheli, Andreas Wack
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 245-256.e4 (2019)
Summary: Type I interferon (IFNα/β) pathways are fine-tuned to elicit antiviral protection while minimizing immunopathology; however, the initiating stimuli, target tissues, and underlying mechanisms are unclear. Using models of physiological and d
Externí odkaz:
https://doaj.org/article/b38812bc603440c1ac47e05b4631b8c3
Autor:
Sophia Davidson, Teresa M McCabe, Stefania Crotta, Hans Henrik Gad, Edith M Hessel, Soren Beinke, Rune Hartmann, Andreas Wack
Publikováno v:
EMBO Molecular Medicine, Vol 8, Iss 9, Pp 1099-1112 (2016)
Abstract Influenza A virus (IAV)‐induced severe disease is characterized by infected lung epithelia, robust inflammatory responses and acute lung injury. Since type I interferon (IFNαβ) and type III interferon (IFNλ) are potent antiviral cytokin
Externí odkaz:
https://doaj.org/article/29e9a7e829bc409682faf9a9dbdbb308
Autor:
Matteo Villa, Stefania Crotta, Kevin S. Dingwell, Elizabeth M. A. Hirst, Manolis Gialitakis, Helena Ahlfors, James C. Smith, Brigitta Stockinger, Andreas Wack
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-11 (2016)
Epithelia are barriers against environmental insults and express the transcription factor aryl hydrocarbon receptor (AhR). Here the authors show that AhR regulates multiciliogenesis via cyclin O and Multicilin in a Notch-dependent manner and that thi
Externí odkaz:
https://doaj.org/article/2586c152044d48ffa6ee83a3bf1f6f6c
Autor:
Stefania Crotta, Sophia Davidson, Tanel Mahlakoiv, Christophe J Desmet, Matthew R Buckwalter, Matthew L Albert, Peter Staeheli, Andreas Wack
Publikováno v:
PLoS Pathogens, Vol 9, Iss 11, p e1003773 (2013)
Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They can be induced by viral infection, are secreted and bind to specific receptors on the same or neighbouring cells to activate the expression of hundreds of IF
Externí odkaz:
https://doaj.org/article/2d13d9968cc0490f91296ce8bbee72a2
Publikováno v:
International Journal of Hepatology, Vol 2011 (2011)
The Hepatitis C virus E1 and E2 envelope proteins are the major players in all events required for virus entry into target cells. In addition, the recently developed HCV cell culture system has indicated that E1E2 heterodimer formation is a prerequis
Externí odkaz:
https://doaj.org/article/e694af8a356e4a32895df274ee105bdf
Autor:
Julius Beer, Stefania Crotta, Angele Breithaupt, Annette Ohnemus, Jan Becker, Benedikt Sachs, Lisa Kern, Miriam Llorian, Nadine Ebert, Fabien Labroussaa, Tran Thi Nhu Thao, Bettina Salome Trueeb, Joerg Jores, Volker Thiel, Martin Beer, Jonas Fuchs, Georg Kochs, Andreas Wack, Martin Schwemmle, Daniel Schnepf
Publikováno v:
Beer, Julius; Crotta, Stefania; Breithaupt, Angele; Ohnemus, Annette; Becker, Jan; Sachs, Benedikt; Kern, Lisa; Llorian, Miriam; Ebert, Nadine; Labroussaa, Fabien; Nhu Thao, Tran Thi; Trueeb, Bettina Salome; Jores, Joerg; Thiel, Volker; Beer, Martin; Fuchs, Jonas; Kochs, Georg; Wack, Andreas; Schwemmle, Martin and Schnepf, Daniel (2022). Impaired immune response drives age-dependent severity of COVID-19. The Journal of experimental medicine, 219(12) Rockefeller Univ. Press 10.1084/jem.20220621
SARS-CoV-2 is a highly contagious respiratory virus and the causative agent for COVID-19. The severity of disease varies from mildly symptomatic to lethal and shows an extraordinary correlation with increasing age, which represents the major risk fac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::86e361b744135e77cace29343a589c2e
https://pubmed.ncbi.nlm.nih.gov/36129445
https://pubmed.ncbi.nlm.nih.gov/36129445