Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Stefania Contini"'
Discovery and structure–activity relationship of a novel spirocarbamate series of NPY Y5 antagonists
Autor:
Jonathan Mark Bentley, Matteo Biagetti, Laura Caberlotto, Colin Philip Leslie, Romano Di Fabio, Thorsten Genski, Daniele Donati, Laura Zonzini, Catia Seri, Sebastien Guery, Stefania Contini, Angelica Mazzali, Domenica Antonia Pizzi, Michela Tessari, Giancarlo Merlo, Fabiola Sacco
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6103-6107
A novel series of trans-8-aminomethyl-1-oxa-3-azaspiro[4.5]decan-2-one derivatives was identified with potent NPY Y5 antagonist activity. Optimization of the original lead furnished compounds 23p and 23u, which combine sub-nanomolar Y5 activity with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f760c980840d16f98ad0723ece4796f8
https://doi.org/10.1016/j.bmcl.2010.08.041
https://doi.org/10.1016/j.bmcl.2010.08.041
Autor:
Claudia Mundi, Sebastien Guery, Alberto Buson, Romano Di Fabio, Sergio Melotto, Federico Faggioni, Chiara Savoia, Michela Tessari, Lucilla D'Adamo, Fabio Maria Sabbatini, Carla Di Francesco, Benedetta Perini, Paolo Cavanni, Giovanna Dal Forno, Steve M. Bromidge, Yves St-Denis, Stefania Contini, Mauro Corsi, Elisabetta Perdona, Francesca Pavone, Marilisa Rinaldi, Carpenter Andrew J, Mario Mattioli
Publikováno v:
ChemMedChem. 5:1450-1455
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::36057954bce91c40c062ae6ddd7a994f
https://doi.org/10.1002/cmdc.201000185
https://doi.org/10.1002/cmdc.201000185
Autor:
Stefania Contini, Emiliangelo Ratti, Aldo Feriani, Frank E. Blaney, David G. Trist, Karen L Roberts, Fabio Maria Sabbatini, Romano Di Fabio, Damiano Ghirlanda, Daniele Donati, Angela Worby, Stefano Provera, Mario Mattioli, Yves St-Denis, Roberto Arban, Elettra Fazzolari, Emiliano Castiglioni, Francesca Pavone, Simone Spada, Enza Di Modugno, Carla Marchioro, Giovanni Bernasconi, Arnaldo Nalin, Anna Mingardi, Anna Maria Capelli, Daniele Andreotti, Simone Braggio, Gabriella Gentile
Publikováno v:
Journal of Medicinal Chemistry. 51:7370-7379
To identify new CRF(1) receptor antagonists, an attempt to modify the bis-heterocycle moiety present in the top region of the dihydropyrrole[2,3]pyridine template was made following new pharmacophoric hypothesis on the CRF(1) receptor antagonists bin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df1d170f99619351713e13794971e418
https://doi.org/10.1021/jm800744m
https://doi.org/10.1021/jm800744m
Publikováno v:
Magnetic Resonance in Chemistry. 39:38-42
The gradient-enhanced 1H,29Si HMQC experiment was applied to tetra-TMS-α-O-methyl-D-glucopyranose and tetra-TES-α-O-methyl-D-glucopyranose as test samples. All the expected 2J(1H, 29Si) and 3J (1H,29Si) cross peaks were observed, allowing the full
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f212da57b26fc97eea0d0c19eecce9b2
https://doi.org/10.1002/1097-458x(200101)39:1<38::aid-mrc794>3.0.co
https://doi.org/10.1002/1097-458x(200101)39:1<38::aid-mrc794>3.0.co
Autor:
Domenica Antonia Pizzi, Stefania Contini, Stefano Biondi, Tino Rossi, Daniele Donati, Filippo Busi, Angelo Pecunioso, Fabio Maria Sabbatini, Micaela Maffeis, Luciana Rossi
Publikováno v:
Tetrahedron. 56:5649-5655
In this paper a highly diastereoselective synthesis of 4-N-methylformamidino trinem 3 is reported. The route offers advantages compared to that previously used, i.e. the higher overall yield, the robustness, the avoidance of toxic reagents. Most of t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5a996b61655e9ecd326b0f35adcb406d
https://doi.org/10.1016/s0040-4020(00)00414-2
https://doi.org/10.1016/s0040-4020(00)00414-2
Autor:
Ugo Azzena, Emma Fenude, Stefania Contini, Giovanni Melloni, Anna Maria Piroddi, Emanuela Azara
Publikováno v:
ChemInform. 23
The behavior of several protected derivatives of 3,4,5-trimethoxybenzaldehyde has been investigated under conditions of electron transfer from alkali metals in aprotic solvents. The 4-methoxy group can be regioselectively removed in good to high yiel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cc8adaa6d1c1880e3c6f30450a7c889
https://doi.org/10.1002/chin.199245143
https://doi.org/10.1002/chin.199245143
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::857229c4b3688c3aefe8a744df92ee49
https://doi.org/10.1002/chin.199605264
https://doi.org/10.1002/chin.199605264
Autor:
Colin Philip Leslie, Laura Zonzini, Stefania Contini, Domenica Antonia Pizzi, Angelica Mazzali, Jonathan Mark Bentley, Matteo Biagetti, Romano Di Fabio, Fabio Maria Sabbatini, Laura Caberlotto, Catia Seri, Thorsten Genski
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(23)
A novel class of benzimidazole NPY Y5 receptor antagonists was prepared exploiting a privileged spirocarbamate moiety. The structure-activity relationship of this series and efforts to achieve a profile suitable for further development and an appropr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049c54b7f1a85d5c01084fd75101e58b
https://pubmed.ncbi.nlm.nih.gov/20951033
https://pubmed.ncbi.nlm.nih.gov/20951033
Autor:
Emma Fenude, Ugo Azzena, Stefania Contini, Giovanni Melloni, Emanuela Azara, Anna Maria Piroddi
Publikováno v:
The Journal of Organic Chemistry. 57:3101-3106
The behavior of several protected derivatives of 3,4,5-trimethoxybenzaldehyde has been investigated under conditions of electron transfer from alkali metals in aprotic solvents. The 4-methoxy group can be regioselectively removed in good to high yiel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f58e5e9012ff77bfc482705870e9b933
https://doi.org/10.1021/jo00037a029
https://doi.org/10.1021/jo00037a029
Autor:
Aldo Feriani, Stefania Contini, Anna Maria Capelli, Daniele Donati, Fabio Maria Sabbatini, Giovanni Bernasconi, Romano Di Fabio, Damiano Ghirlanda, Angela Worby, Roberto Arban, Elettra Fazzolari, Emiliano Castiglioni, Emiliangelo Ratti, Frank E. Blaney, Daniele Andreotti, Yves St-Denis, Gabriella Gentile, Simone Braggio, Simone Spada, Carla Marchioro
Publikováno v:
Journal of medicinal chemistry. 51(22)
In an effort to discover novel CRF-1 receptor antagonists exhibiting improved physicochemical properties, a dihydropirrole[2,3]pyridine scaffold was designed and explored in terms of the SAR of the substitution at the pendent phenyl ring and the natu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffa4248800937fe29d8753d63b2ab04
https://pubmed.ncbi.nlm.nih.gov/18975927
https://pubmed.ncbi.nlm.nih.gov/18975927