Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Stefania Baraldi"'
Autor:
Romeo Romagnoli, Filippo Prencipe, Luisa Carlota Lopez-Cara, Paola Oliva, Stefania Baraldi, Pier Giovanni Baraldi, Francisco Estévez-Sarmiento, José Quintana, Francisco Estévez
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 727-742 (2018)
The combination of two pharmacophores into a single molecule represents one of the methods that can be adopted for the synthesis of new anticancer molecules. To investigate the influence of the position of the pyridine nitrogen on biological activity
Externí odkaz:
https://doaj.org/article/c952a4ba515b4ef2aa958ab1d731b780
Autor:
Paola Oliva, Romeo Romagnoli, Elena Mariotto, Luisa Carlota Lopez-Cara, Salvatore Ferla, Maria Kimatrai Salvador, Elena Mattiuzzo, Andrea Brancale, Mariem Chayah, Filippo Prencipe, Ernest Hamel, Giampietro Viola, Roberto Ronca, Roberta Bortolozzi, Santiago Schiaffino Ortega, Stefania Baraldi, Pier Giovanni Baraldi
Publikováno v:
Journal of Medicinal Chemistry. 62:1274-1290
The clinical evidence for the success of tyrosine kinase inhibitors in combination with microtubule-targeting agents prompted us to design and develop single agents that possess both epidermal growth factor receptor (EGFR) kinase and tubulin polymeri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3d60e2108fe51c21f512f9adf41556
https://doi.org/10.1021/acs.jmedchem.8b01391
https://doi.org/10.1021/acs.jmedchem.8b01391
Autor:
Stefania Gessi, Stefania Baraldi, Antonella Ciancetta, Pier Giovanni Baraldi, Kenneth A. Jacobson, Katia Varani, Pier Andrea Borea, Dilip K. Tosh, Zhan-Guo Gao, Stefania Merighi, Romeo Romagnoli, Mojgan Aghazadeh Tabrizi
Publikováno v:
Medicinal Research Reviews. 38:1031-1072
The A3 adenosine receptor (A3 AR) subtype is a novel, promising therapeutic target for inflammatory diseases, such as rheumatoid arthritis (RA) and psoriasis, as well as liver cancer. A3 AR is coupled to inhibition of adenylyl cyclase and regulation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::877f3f5fa131012159dba1c314a2852c
https://doi.org/10.1002/med.21456
https://doi.org/10.1002/med.21456
Autor:
Pier Andrea Borea, Stefania Merighi, Stefania Gessi, Mojgan Aghazadeh Tabrizi, Stefania Baraldi, Pier Giovanni Baraldi
Publikováno v:
Medicinal Research Reviews. 37:936-983
Transient receptor potential vanilloid 1 (TRPV1) is an ion channel expressed on sensory neurons triggering an influx of cations. TRPV1 receptors function as homotetramers responsive to heat, proinflammatory substances, lipoxygenase products, resinife
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bd0eb4fdf5f46f0d767b933eeea53a6e
https://doi.org/10.1002/med.21427
https://doi.org/10.1002/med.21427
Autor:
Elena Mattiuzzo, Sandra Liekens, Paola Oliva, Andrea Brancale, Giampietro Viola, Pier Giovanni Baraldi, Ernest Hamel, Santiago Schiaffino Ortega, Romeo Romagnoli, Luisa Carlota Lopez-Cara, Maria Kimatrai Salvador, Giuseppe Basso, Salvatore Ferla, Jan Balzarini, Stefania Baraldi
Microtubules are recognized as crucial components of the mitotic spindle during cell division, and, for this reason, the microtubule system is an attractive target for the development of anticancer agents. Continuing our search strategy for novel tub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b66f801166c66640da5f9f0923b5438
http://hdl.handle.net/11577/3254722
http://hdl.handle.net/11577/3254722
Autor:
Paola Oliva, Stefania Baraldi, Antonella Ciancetta, Kenneth A. Jacobson, Kiran S. Toti, Pier Giovanni Baraldi
Publikováno v:
The Adenosine Receptors ISBN: 9783319908076
Many selective agonists and antagonists of the A2A adenosine receptor (AR) have been reported, while allosteric modulators specific for this receptor are still needed. Many heterocyclic chemotypes have been discovered as A2AAR antagonists, while most
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6730a0aa29dc136c523eef121fd5aa87
https://doi.org/10.1007/978-3-319-90808-3_5
https://doi.org/10.1007/978-3-319-90808-3_5
Autor:
Andrea Chicca, Jürg Gertsch, Lorenzo Di Cesare Mannelli, Margherita Lapillo, Stefania Baraldi, Carlotta Granchi, Emanuela Ruggiero, Carla Ghelardini, Adriano Martinelli, Lucia De Stefano, Pier Giovanni Baraldi, Clementina Manera, Mojgan Aghazadeh Tabrizi, Tiziano Tuccinardi, Filippo Minutolo, Marco Macchia, Flavio Rizzolio
Monoacylglycerol lipase (MAGL) is a serine hydrolase that plays an important role in the degradation of the endocannabinoid neurotransmitter 2-arachidonoylglycerol, which is implicated in many physiological processes. Beyond the possible utilization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b2f78d4c3b4dbb5fb5316f94c27de2
http://hdl.handle.net/11568/910566
http://hdl.handle.net/11568/910566
Autor:
Emanuela Ruggiero, Stefania Baraldi, Romeo Romagnoli, Katia Varani, Mojgan Aghazadeh Tabrizi, Pier Andrea Borea, Fabrizio Vincenzi, Pier Giovanni Baraldi, Giulia Saponaro
Publikováno v:
Journal of Medicinal Chemistry. 58:5355-5360
In this paper we describe an extension SAR study of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine nucleus as A3AR antagonist. Our initial aim was to replace the phenylcarbamoyl moiety at the 5 position of PTP nucleus with a thiourea functionality t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8091538f9e0cc19abcd807c4c78eed
https://doi.org/10.1021/acs.jmedchem.5b00551
https://doi.org/10.1021/acs.jmedchem.5b00551
Autor:
Rodolfo C. outo Maia, Nelilma C. Romeiro, Debora Fazzi, Filippo Prencipe, Carlos A. M. Fraga, Angela Stefanelli, Stefania Gessi, Pier Andrea Borea, Pier Giovanni Baraldi, Romeo Romagnoli, Delia Preti, Giulia Saponaro, E.J. Barreiro, Stefania Baraldi, Stefania Merighi, Mojgan Aghazadeh Tabrizi
Publikováno v:
Medicinal Chemistry. 11:342-353
A series of 1,3,6-triphenylpyrazolo[3,4- b ]pyridin-4-one derivatives was designed, synthesized and evaluated for cytotoxic activity in A375 human melanoma and human erythroleukemia (HEL) cells. The new pyrazolopyridones displayed comparable activiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ad809e61a28b39b7a3baba8e37474539
https://doi.org/10.2174/1573406411666141210141317
https://doi.org/10.2174/1573406411666141210141317
Autor:
Ernest Hamel, Roberta Bortolozzi, Romeo Romagnoli, Paola Oliva, Maria Kimatrai Salvador, Elena Mariotto, Elena Porcù, Roberto Ronca, Luisa Carlota Lopez-Cara, Giuseppe Basso, Giampietro Viola, Stefania Baraldi, Filippo Prencipe, Salvatore Ferla, Pier Giovanni Baraldi, Andrea Brancale
Publikováno v:
Scientific Reports
Antimitotic agents that interfere with microtubule formation are one of the major classes of cytotoxic drugs for cancer treatment. Multiple 2-methyl-4-(3′,4′,5′-trimethoxyphenyl)-5-substituted oxazoles and their related 4-substituted-5-(3′,4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c74f7e90e55448158b231cbf105a9be5
https://doi.org/10.1038/srep46356
https://doi.org/10.1038/srep46356