Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Stefania Baldursdottir"'
Autor:
Pernille Barbre Pedersen, Ragna Berthelsen, Thomas Rades, Søren Astrup Jørgensen, Peter Vilmann, Daniel Bar-Shalom, Stefania Baldursdottir, Anette Müllertz
Publikováno v:
Pedersen, P B, Berthelsen, R, Rades, T, Jørgensen, S A, Vilmann, P, Bar-Shalom, D, Baldursdottir, S & Müllertz, A 2022, ' Physico-chemical characterization of aspirated and simulated human gastric fluids to study their influence on the intrinsic dissolution rate of cinnarizine ', International Journal of Pharmaceutics, vol. 622, 121856 . https://doi.org/10.1016/j.ijpharm.2022.121856
To elucidate the critical parameters affecting drug dissolution in the human stomach, the intrinsic dissolution rate (IDR) of cinnarizine was determined in aspirated and simulated human gastric fluids (HGF). Fasted aspirated HGF (aspHGF) was collecte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b5b70034ebab6407f1b59e00362b8a
https://curis.ku.dk/portal/da/publications/physicochemical-characterization-of-aspirated-and-simulated-human-gastric-fluids-to-study-their-influence-on-the-intrinsic-dissolution-rate-of-cinnarizine(32ec6d42-b295-4877-ba95-c8bd6bc3ad65).html
https://curis.ku.dk/portal/da/publications/physicochemical-characterization-of-aspirated-and-simulated-human-gastric-fluids-to-study-their-influence-on-the-intrinsic-dissolution-rate-of-cinnarizine(32ec6d42-b295-4877-ba95-c8bd6bc3ad65).html
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 142:315-321
This study aims to investigate the potential of solid lipid microparticles (MP) and hybrid polymer-lipid MPs for sustained delivery of a peptide drug, leuprolide. A peptide-phospholipid complex was prepared to increase the compatibility of the peptid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1630bb21de9c81c6d5c8b7ecc376b5b0
https://doi.org/10.1016/j.ejpb.2019.07.010
https://doi.org/10.1016/j.ejpb.2019.07.010
Autor:
Fridolin Okkels, Camilla Sander, Stefania Baldursdottir, Vibeke Jessen, Jukka Rantanen, Pernille Kjærgaard Qwist
Publikováno v:
European Journal of Pharmaceutical Sciences. 128:36-42
The rheological profile of a semi-solid product is a critical quality attribute. To monitor changes of this attribute during manufacturing, it would be beneficial to measure the rheological parameters in an on-line or in-line mode and implement this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::386d29444a30c1c12f25a74a37d89cdd
https://doi.org/10.1016/j.ejps.2018.11.014
https://doi.org/10.1016/j.ejps.2018.11.014
Autor:
Johan Bøtker, Jukka Rantanen, Jeroen Van Renterghem, Dhara Raijada, Johanna Aho, Lærke Arnfast, Stefania Baldursdottir, Thomas De Beer
Publikováno v:
Pharmaceutics, Vol 12, Iss 2, p 116 (2020)
Arnfast, L, van Renterghem, J, Aho, J, Bøtker, J, Raijada, D, Baldursdóttir, S, De Beer, T & Rantanen, J 2020, ' Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy ', Pharmaceutics, vol. 12, no. 2, 116 . https://doi.org/10.3390/pharmaceutics12020116
Pharmaceutics
Volume 12
Issue 2
Arnfast, L, van Renterghem, J, Aho, J, Bøtker, J, Raijada, D, Baldursdóttir, S, De Beer, T & Rantanen, J 2020, ' Exploring the Complexity of Processing-Induced Dehydration during Hot Melt Extrusion Using In-Line Raman Spectroscopy ', Pharmaceutics, vol. 12, no. 2, 116 . https://doi.org/10.3390/pharmaceutics12020116
Pharmaceutics
Volume 12
Issue 2
The specific aim in this study was to understand the effect of critical process parameters on the solid form composition of model drug compounds during hot melt extrusion using in-line Raman spectroscopy combined with Multivariate Curve Resolution-Al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c38f3ff2ccdbcaebf87132ff1630c13
https://www.mdpi.com/1999-4923/12/2/116
https://www.mdpi.com/1999-4923/12/2/116
Publikováno v:
International Journal of Pharmaceutics. 550:439-446
The study aimed at investigating the potential of spray drying method for encapsulation of protein drugs into solid lipid microparticles (MP) and evaluating effects of excipients on encapsulation and release of protein from MP. After transformation o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dd0e964548c9fa60c18fd8a295ca02
https://doi.org/10.1016/j.ijpharm.2018.09.007
https://doi.org/10.1016/j.ijpharm.2018.09.007
Autor:
Stefania Baldursdottir, Mingshi Yang, Hanne Mørck Nielsen, Feng Wan, Tommy Nylander, Sylvia Natalie Kłodzińska, Camilla Foged
Publikováno v:
ACS Applied Materials & Interfaces. 10:10678-10687
Nanoparticle (NP) mediated drug delivery into viscous biomatrices, e.g., mucus and bacterial biofilms, is challenging. Lipid shell-enveloped polymeric NPs (Lipid@NPs), composed of a polymeric NP core coated with a lipid shell, represent a promising a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c00ac75572b06261b4fabd61f99fed9f
https://doi.org/10.1021/acsami.7b19762
https://doi.org/10.1021/acsami.7b19762
Publikováno v:
Journal of Drug Delivery Science and Technology. 43:65-72
The present study aimed at investigating the influence of lipid excipients on protein carriers when proteins are encapsulated in lipid and PLGA hybrid particles. PLGA and lipid hybrid microparticles (MP) were prepared by a double emulsion method, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::15f786ce080bdb9a8240f9b795d2b70a
https://doi.org/10.1016/j.jddst.2017.09.006
https://doi.org/10.1016/j.jddst.2017.09.006
Autor:
Amanda Halme, Stefania Baldursdottir, Adam Bohr, Johanna Aho, Niklas Sandler, Jukka Rantanen, Johan Boetker, Jorrit Jeroen Water
Publikováno v:
Carbohydrate Polymers. 177:433-442
Porous implants or implantable scaffolds used for tissue regeneration can encourage tissue growth inside the implant and provide extended drug release. Water-soluble polymers incorporated into a biodegradable or inert implant matrix may leach out upo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41d26dc2399f1d920ba57692c88f1671
https://doi.org/10.1016/j.carbpol.2017.08.135
https://doi.org/10.1016/j.carbpol.2017.08.135
Autor:
Kamruzzaman, Thomas Rades, Jukka Rantanen, Korbinian Löbmann, Stefania Baldursdottir, Johanna Aho, Lærke Arnfast
Publikováno v:
Pharmaceutical Research. 34:2689-2697
Many future drug products will be based on innovative manufacturing solutions, which will increase the need for a thorough understanding of the interplay between drug material properties and processability. In this study, hot melt extrusion of a drug
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3840692faf2b4612e7be78fea506151f
https://doi.org/10.1007/s11095-017-2254-8
https://doi.org/10.1007/s11095-017-2254-8
Autor:
Henrik Jensen, Fengbin Ye, Jesper Østergaard, Stefania Baldursdottir, Anan Yaghmur, Claus Larsen, Susan Weng Larsen, Søren Hvidt
Publikováno v:
Molecular Pharmaceutics. 13:819-828
In the field of drug delivery to the articular cartilage, it is advantageous to apply artificial tissue models as surrogates of cartilage for investigating drug transport and release properties. In this study, artificial cartilage models consisting o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c813b79fe031e0a8966f028c4b9a0cb8
https://doi.org/10.1021/acs.molpharmaceut.5b00725
https://doi.org/10.1021/acs.molpharmaceut.5b00725