Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Stefania, Rocca"'
Autor:
Pietro Poggio, Stefania Rocca, Federica Fusella, Roberta Ferretti, Ugo Ala, Flora D’Anna, Emilia Giugliano, Cristina Panuzzo, Diletta Fontana, Valeria Palumbo, Giovanna Carrà, Daniela Taverna, Carlo Gambacorti-Passerini, Giuseppe Saglio, Carmen Fava, Rocco Piazza, Alessandro Morotti, Francesca Orso, Mara Brancaccio
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-11 (2024)
Abstract Morgana is a ubiquitous HSP90 co-chaperone protein coded by the CHORDC1 gene. Morgana heterozygous mice develop with age a myeloid malignancy resembling human atypical myeloid leukemia (aCML), now renamed MDS/MPN with neutrophilia. Patients
Externí odkaz:
https://doaj.org/article/6c827363c8c04882b2a5e5aa1fda4491
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-12 (2018)
Abstract Atypical Chronic Myeloid Leukemia (aCML) is a myeloproliferative neoplasm characterized by neutrophilic leukocytosis and dysgranulopoiesis. From a genetic point of view, aCML shows a heterogeneous mutational landscape with mutations affectin
Externí odkaz:
https://doaj.org/article/40065103f2c14348b405ee7bcbed3812
Autor:
Federica Fusella, Laura Seclì, Elena Busso, Anna Krepelova, Enrico Moiso, Stefania Rocca, Laura Conti, Laura Annaratone, Cristina Rubinetto, Maurizia Mello-Grand, Vijay Singh, Giovanna Chiorino, Lorenzo Silengo, Fiorella Altruda, Emilia Turco, Alessandro Morotti, Salvatore Oliviero, Isabella Castellano, Federica Cavallo, Paolo Provero, Guido Tarone, Mara Brancaccio
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
NF-κB regulates inflammation, cell survival, proliferation, and metastasis and is often hyperactivated in triple-negative breast cancer. Here the authors show that Morgana, a protein highly expressed in triple-negative breast cancers, drives NF-kB a
Externí odkaz:
https://doaj.org/article/12fe3e6cb2cb4e56ad2f805e25c15661
The issue of public shareholdings is particularly delicate due to the extent of the phenomenon, the impact on the community of their activities and the amount of public money invested in them. The objective of this work – which should be considered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=od______4034::c4f78ed58ba7c6d811d1ec551d3b51d5
https://hdl.handle.net/11587/448734
https://hdl.handle.net/11587/448734
Autor:
Anna Krepelova, Laura Seclì, Federica Cavallo, Federica Fusella, Maurizia Mello-Grand, Alessandro Morotti, Giovanna Chiorino, Lorenzo Silengo, Stefania Rocca, Cristina Rubinetto, Guido Tarone, Salvatore Oliviero, Emilia Turco, Isabella Castellano, Elena Busso, Fiorella Altruda, Mara Brancaccio, Laura Conti, Laura Annaratone, Vijay Singh, Enrico Moiso, Paolo Provero
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Nature Communications
Nature Communications
NF-κB is a transcription factor involved in the regulation of multiple physiological and pathological cellular processes, including inflammation, cell survival, proliferation, and cancer cell metastasis. NF-κB is frequently hyperactivated in severa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d12f258f4a97fb7dfa25be4704f10be
https://doaj.org/article/12fe3e6cb2cb4e56ad2f805e25c15661
https://doaj.org/article/12fe3e6cb2cb4e56ad2f805e25c15661
Publikováno v:
Molecular Cancer, Vol 17, Iss 1, Pp 1-12 (2018)
Molecular Cancer
Molecular Cancer
Atypical Chronic Myeloid Leukemia (aCML) is a myeloproliferative neoplasm characterized by neutrophilic leukocytosis and dysgranulopoiesis. From a genetic point of view, aCML shows a heterogeneous mutational landscape with mutations affecting signal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18afb2a934b56aa98d197a8723b5112d
https://doi.org/10.1186/s12943-018-0774-4
https://doi.org/10.1186/s12943-018-0774-4
Myeloproliferative neoplasms (MPNs) are defined according to the 2008 World Health Organization (WHO) classification and the recent 2016 revision. Over the years, several genetic lesions have been associated with the development of MPNs, with importa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::17908c5191790d218b4be7b618df3ab0
http://hdl.handle.net/2318/1619363
http://hdl.handle.net/2318/1619363
Autor:
Laura Seclì, Federica Fusella, Cristina Rubinetto, Emilia Turco, Stefania Rocca, G. Fragale, Mara Brancaccio
Publikováno v:
ESMO Open. 3:A319
Introduction Morgana is a ubiquitously expressed protein with chaperone activity per se and HSP90 co-chaperone function. High Morgana expression correlates with high tumour grade, mitosis number, and lymph node positivity in different breast cancer s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::429c65fd40510469115f0491634e166c
https://doi.org/10.1136/esmoopen-2018-eacr25.753
https://doi.org/10.1136/esmoopen-2018-eacr25.753
Autor:
Mara Brancaccio, Ugo Ala, Emilia Turco, Paolo Provero, F. D’Anna, Francesca Orso, Federica Fusella, Daniela Taverna, Stefania Rocca
Publikováno v:
ESMO Open. 3:A368
Introduction Morgana is a chaperone protein encoded by the CHORDC1 gene. Its deletion is embryonic lethal due to apoptosis of the cells of the inner cell mass. We recently characterised the role of Morgana in myeloid malignancies, as the haploinsuffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a8988ab88d6b9e486e1e75b67f0bb4c3
https://doi.org/10.1136/esmoopen-2018-eacr25.868
https://doi.org/10.1136/esmoopen-2018-eacr25.868
Autor:
Sabrina Crivellaro, Ubaldo Familiari, Mara Brancaccio, Emilia Turco, Alessandro Morotti, Giovanna Carrà, Emilia Giugliano, Rocco Piazza, Mauro Papotti, Juan Carlos Cutrin, Federica Fusella, Cristina Panuzzo, Emilio Hirsch, Carlo Gambacorti-Passerini, Giuseppe Saglio, Giovanna Rege-Cambrin, Lorenzo Silengo, Guido Tarone, Pier Paolo Pandolfi, Roberta Ferretti, Annalisa Camporeale, Irene Franco, Augusta Di Savino, Stefania Rocca, Barbara Miniscalco
We recently described morgana as an essential protein able to regulate centrosome du- plication and genomic stability, by inhibiting ROCK. Here we show that morgana 1/2 mice spontaneously develop a lethal myeloproliferative disease resembling human a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8691fd371733cfeef1e5e66b04c1e13a
http://hdl.handle.net/10281/95036
http://hdl.handle.net/10281/95036