Zobrazeno 1 - 10
of 80
pro vyhledávání: '"Stefania, Risso"'
Autor:
John A. Morrow, Robert Mazzola, Cristian Salinas, Eric D. Hostetler, Stefania Risso, Fiona Thomson, Tjerk Bueters, Nicholas B. Hastings, Jenny Wai, Sony Agrawal, Liza Gantert, Brian C. Magliaro, Paul McQuade, Zhizhen Zeng, Marie A. Holahan, David Hesk, Melissa Egbertson, Jeffrey W. Schubert, Ling Tong, Robert Gomez, Jongrock Kong, Aniket Joshi, Frederick J. Monsma, David M. Tellers, Kristen L.G. Jones, Jason M. Uslaner, Jing Liao, Patricia Miller, Michelle Smith, Oleg Selyutin, Kerry Riffel, Xiaolei Gao, Scott T. Harrison, Zhaoyang Meng, James Mulhearn, Michael Man-Chu Lo, Wenping Li, Michael T. Rudd, Barbara Hanney, Mona Purcell, Jianming Bao, Hyking Haley
Publikováno v:
Journal of Medicinal Chemistry. 63:2411-2425
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::949c4dbede58ed2de44d27f608635d36
https://doi.org/10.1021/acs.jmedchem.9b01406
https://doi.org/10.1021/acs.jmedchem.9b01406
Autor:
Sarah L Huszar Agrapides, Susan E. Browne, Jeffrey W. Schubert, Jaime Lynn Bunda, Robert Gomez, Tynebor Robert M, John M. Sanders, Melissa Egbertson, Kristen L.G. Jones, Jason M. Uslaner, Natasa Pajkovic, James Mulhearn, Anthony L. Gotter, Christopher D. Cox, Brian C. Magliaro, Barbara Hanney, Jenny Wai, Julie A. O'Brien, Scott T. Harrison, Stefania Risso, Anne Marie Taylor, John A. Mccauley, Sean M. Smith
Publikováno v:
ChemMedChem. 14:943-951
Herein we describe the discovery and optimization of a new series of 2,3-disubstituted and 2,3,6-trisubstituted muscarinic acetylcholine receptor 4 (M4 ) positive allosteric modulators (PAMs). Iterative libraries enabled rapid exploration of one-dime
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::77782222be3d0457fcb67bd3fe6f175d
https://doi.org/10.1002/cmdc.201900088
https://doi.org/10.1002/cmdc.201900088
Autor:
Ling, Tong, Wenping, Li, Michael Man-Chu, Lo, Xiaolei, Gao, Jenny Miu-Chen, Wai, Michael, Rudd, David, Tellers, Aniket, Joshi, Zhizhen, Zeng, Patricia, Miller, Cristian, Salinas, Kerry, Riffel, Hyking, Haley, Mona, Purcell, Marie, Holahan, Liza, Gantert, Jeffrey W, Schubert, Kristen, Jones, James, Mulhearn, Melissa, Egbertson, Zhaoyang, Meng, Barbara, Hanney, Robert, Gomez, Scott T, Harrison, Paul, McQuade, Tjerk, Bueters, Jason, Uslaner, John, Morrow, Fiona, Thomson, Jongrock, Kong, Jing, Liao, Oleg, Selyutin, Jianming, Bao, Nicholas B, Hastings, Sony, Agrawal, Brian C, Magliaro, Frederick J, Monsma, Michelle D, Smith, Stefania, Risso, David, Hesk, Eric, Hostetler, Robert, Mazzola
Publikováno v:
Journal of medicinal chemistry. 63(5)
The measurement of receptor occupancy (RO) using positron emission tomography (PET) has been instrumental in guiding discovery and development of CNS directed therapeutics. We and others have investigated muscarinic acetylcholine receptor 4 (M4) posi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cd3ef3c047c980065bd64efde0a0b7e9
https://pubmed.ncbi.nlm.nih.gov/32101422
https://pubmed.ncbi.nlm.nih.gov/32101422
Autor:
Jeffrey W, Schubert, Scott T, Harrison, James, Mulhearn, Robert, Gomez, Robert, Tynebor, Kristen, Jones, Jaime, Bunda, Barbara, Hanney, Jenny Miu-Chen, Wai, Chris, Cox, John A, McCauley, John M, Sanders, Brian, Magliaro, Julie, O'Brien, Natasa, Pajkovic, Sarah L, Huszar Agrapides, Anne, Taylor, Anthony, Gotter, Sean M, Smith, Jason, Uslaner, Susan, Browne, Stefania, Risso, Melissa, Egbertson
Publikováno v:
ChemMedChem. 14(9)
Herein we describe the discovery and optimization of a new series of 2,3-disubstituted and 2,3,6-trisubstituted muscarinic acetylcholine receptor 4 (M
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::475ab82d66001ed942e40ff31fcd1945
https://pubmed.ncbi.nlm.nih.gov/30920765
https://pubmed.ncbi.nlm.nih.gov/30920765
Publikováno v:
In Respiration Physiology 2001 129(1):175-189
Publikováno v:
2017 Medicinal Chemistry Reviews ISBN: 9780996293242
2017 Medicinal Chemistry Reviews
2017 Medicinal Chemistry Reviews
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b466cc109d6a475c4ab96cb18eff3553
https://doi.org/10.29200/acsmedchemrev-v52.ch22
https://doi.org/10.29200/acsmedchemrev-v52.ch22
Autor:
Tracy A. Spalding, Robert E. Davis, Abhishek Bajpai, Thomas R. Ott, Mikael Friberg, Jelveh Lameh, Krista McFarland, Stefania Risso Bradley, Derek Nguyen, Ali Tabatabaei, Linda Ohrmund, Hans H. Schiffer, Douglas W. Bonhaus, Ethan S. Burstein, Thomas Son
Publikováno v:
Neuropharmacology. 58:365-373
The recent discovery of allosteric potentiators and agonists of the muscarinic M(1) receptor represents a significant advance in the muscarinic receptor pharmacology. In the current study we describe the receptor pharmacology and pro-cognitive action
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ea3cde7b5fcbb28425788ac8a6837a5
https://doi.org/10.1016/j.neuropharm.2009.10.003
https://doi.org/10.1016/j.neuropharm.2009.10.003
Autor:
Fabrizio Badalassi, Roger Olsson, Fabrice Piu, Mikkel B. Thygesen, Rasmus Lewinsky, Birgitte W. Lund, Fabio Bertozzi, Jan Pawlas, Nathalie Schlienger, Ali Tabatabaei, Luis R. Gardell, Stefania Risso Bradley, Alma Fejzic
Publikováno v:
Journal of Medicinal Chemistry. 52:7186-7191
Herein we describe the discovery of ACP-105 (1), a novel and potent nonsteroidal selective androgen receptor modulator (SARM) with partial agonist activity relative to the natural androgen testosterone. Compound 1 was developed from a series of compo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0555062df61233105cc9d55a61a7b630
https://doi.org/10.1021/jm901149c
https://doi.org/10.1021/jm901149c
Publikováno v:
Letters in Drug Design & Discovery. 5:271-276
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ea2a4eee7860c36d2d618b37a1aac37
https://doi.org/10.2174/157018008784619898
https://doi.org/10.2174/157018008784619898
Autor:
Stefania Risso Bradley, Hans H. Schiffer, Roger Olsson, Robert E. Davis, Luis R. Gardell, Fabrice Piu, Thomas Son, K.E. Vanover, Nathalie Schlienger, Birgitte W. Lund
Publikováno v:
The Journal of Steroid Biochemistry and Molecular Biology. 109:129-137
Because of the limitations and liabilities of current testosterone therapies, non-steroidal tissue-selective androgen receptor modulators may provide a clinically meaningful advance in therapy. Using a functional cell-based assay AC-262536 was identi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4dbcba16f8dfbb47e08f41256c174ac
https://doi.org/10.1016/j.jsbmb.2007.11.001
https://doi.org/10.1016/j.jsbmb.2007.11.001