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of 2
pro vyhledávání: '"Stefani E. Lucarelli"'
Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
Autor:
Allison L. Didychuk, Eric J. Montemayor, Tucker J. Carrocci, Andrew T. DeLaitsch, Stefani E. Lucarelli, William M. Westler, David A. Brow, Aaron A. Hoskins, Samuel E. Butcher
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
The mechanism of U6 small nuclear ribonucleoprotein (snRNP) biogenesis is not well understood. Here the authors characterize the enzymatic activities and structures of yeast and human U6 RNA processing enzyme Usb1, reconstitute post-transcriptional a
Externí odkaz:
https://doaj.org/article/af0bae0e35e0403b9769387c02748283
Usb1 controls U6 snRNP assembly through evolutionarily divergent cyclic phosphodiesterase activities
Autor:
Andrew T. DeLaitsch, William M. Westler, Allison L. Didychuk, David A. Brow, Eric J. Montemayor, Tucker J. Carrocci, Stefani E. Lucarelli, Aaron A. Hoskins, Samuel E. Butcher
Publikováno v:
Nature Communications
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
Nature Communications, Vol 8, Iss 1, Pp 1-13 (2017)
U6 small nuclear ribonucleoprotein (snRNP) biogenesis is essential for spliceosome assembly, but not well understood. Here, we report structures of the U6 RNA processing enzyme Usb1 from yeast and a substrate analog bound complex from humans. Unlike
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb797231dcbec089f74ef8516d9ab981
https://pubmed.ncbi.nlm.nih.gov/28887445
https://pubmed.ncbi.nlm.nih.gov/28887445