Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Stefan Zahov"'
Publikováno v:
Bioorganic & Medicinal Chemistry. 25:825-837
The serine hydrolase fatty acid amide hydrolase (FAAH) catalyzes the degradation of the endocannabinoid anandamide, which possesses analgesic and anti-inflammatory effects. A new series of 1-heteroarylpropan-2-ones was synthesized and evaluated for F
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df278c8c9bd39dc9024764de9e783e22
https://doi.org/10.1016/j.bmc.2016.11.025
https://doi.org/10.1016/j.bmc.2016.11.025
Publikováno v:
European journal of medicinal chemistry. 160
A series of derivatives of 1-(4-octylphenoxy)-3-(2H-tetrazol-2-yl)propan-2-one (3) and 1-(4-octylphenoxy)-3-(1H-tetrazol-1-yl)propan-2-one (4) was synthesized and tested for fatty acid amide hydrolase (FAAH) inhibitory potency and phase I metabolic s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d5c62eb5f9c777ea07a08b5223cc2c1
https://pubmed.ncbi.nlm.nih.gov/30340141
https://pubmed.ncbi.nlm.nih.gov/30340141
Publikováno v:
AIP Conference Proceedings.
This paper presents the concept and the modern advances in architecture, models and services in cloud. The goal of the paper is the development of cloud architecture and to show how an absolutely secure, fast and powerful cloud computing environment
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9610bb57b1faecc69a6f7f341ca82cef
https://doi.org/10.1063/1.5082133
https://doi.org/10.1063/1.5082133
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:1100-1112
2-α-Keto oxazoles containing polar head groups in their C5-side chains were designed as fatty acid amide hydrolase (FAAH) inhibitors. Variation in the spacer length resulted in submicromolar α-keto-oxazole FAAH inhibitor (IC50 = 436 nM) presenting
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f7f155178f6fa7c81a1bf044ddee611
https://doi.org/10.1016/j.bmc.2011.11.027
https://doi.org/10.1016/j.bmc.2011.11.027
Publikováno v:
ChemMedChem. 6:544-549
Cytosolic phospholipase A2α (cPLA2α) and fatty acid amide hydrolase (FAAH) are enzymes that have emerged as attractive targets for the development of analgesic and anti-inflammatory drugs. We recently reported that 1-[3-(4-octylphenoxy)-2-oxopropyl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b76d955c605609ec41dc4a09a11260e7
https://doi.org/10.1002/cmdc.201000473
https://doi.org/10.1002/cmdc.201000473