Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Stefan Westin"'
Autor:
Mary Petrowski, Tie-Lin Wang, Paige Mahaney, Chris L. Daige, Richard Martin, Grace Yan, Jay Wrobel, Jiali Li, Parinaz C. Pircher, Xiao-Hui Gu, Eric D. Bischoff, Raju Mohan, Stefan Westin, Brenton T. Flatt, Paul Foster, Brett Murphy, Ira G. Schulman
Publikováno v:
Journal of Medicinal Chemistry. 52:904-907
Azepino[4,5-b]indoles have been identified as potent agonists of the farnesoid X receptor (FXR). In vitro and in vivo optimization has led to the discovery of 6m (XL335, WAY-362450) as a potent, selective, and orally bioavailable FXR agonist (EC(50)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22bdda82f6d2ea078670fd48d355abad
https://doi.org/10.1021/jm8014124
https://doi.org/10.1021/jm8014124
Publikováno v:
Mini-Reviews in Medicinal Chemistry. 5:719-727
The farnesoid X receptor (FXR) is a nuclear receptor expressed in tissues exposed to high concentrations of bile acids such as the liver, kidney and intestine and functions as a bile acid sensor. FXR regulates the expression of various transport prot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66368651adb010e282ab755d0b6d9578
https://doi.org/10.2174/1389557054553802
https://doi.org/10.2174/1389557054553802
Autor:
Juan Llopis, Stefan Westin, Roger Y. Tsien, Riki Kurokawa, Michael G. Rosenfeld, Christopher K. Glass, David W. Rose, Charles Y. Cho, Jiahong Wang, Mercedes Ricote, Tina-Marie Mullen
Publikováno v:
Proceedings of the National Academy of Sciences. 97:4363-4368
Members of the nuclear receptor superfamily are thought to activate transcription by recruitment of one or more recently identified coactivator complexes. Here we demonstrate that both peroxisome proliferator-activated receptor binding protein (PBP)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::48144722f340fc17e43209df92f1d091
https://doi.org/10.1073/pnas.97.8.4363
https://doi.org/10.1073/pnas.97.8.4363
Autor:
David W. Rose, Nuria Assa-Munt, Joseph Torchia, Michael V. Milburn, Tina-Marie Mullen, Stefan Westin, Anna Krones, Michael G. Rosenfeld, Robert T. Nolte, Eileen M. McInerney, Juan Inostroza, Sarah E. Flynn, Christopher K. Glass
Publikováno v:
Genes & Development. 12:3357-3368
Ligand-dependent activation of gene transcription by nuclear receptors is dependent on the recruitment of coactivators, including a family of related NCoA/SRC factors, via a region containing three helical domains sharing an LXXLL core consensus sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e246279871159d16b3fb4d8007459536
https://doi.org/10.1101/gad.12.21.3357
https://doi.org/10.1101/gad.12.21.3357
Autor:
D W Rose, Stefan Westin, Wisely Gb, Michael V. Milburn, Eileen M. McInerney, Michael G. Rosenfeld, Robert T. Nolte, Riki Kurokawa, Christopher K. Glass
Publikováno v:
Nature. 395:199-202
Retinoic-acid receptor-α (RAR-α) and peroxisome proliferator-activated receptor-γ (PPAR-γ) are members of the nuclear-receptor superfamily that bind to DNA as heterodimers with retinoid-X receptors (RXRs)1,2. PPAR–RXR heterodimers can be activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aac904443bbbaf7a54168f8339d8eab
https://doi.org/10.1038/26040
https://doi.org/10.1038/26040
Autor:
Joseph Torchia, Juan Inostroza, Christopher K. Glass, Michael G. Rosenfeld, David W. Rose, Stefan Westin, Yasutomi Kamei
Publikováno v:
Nature. 387:677-684
The functionally conserved proteins CBP and p300 act in conjunction with other factors to activate transcription of DNA. A new factor, p/CIP, has been discovered that is present in the cell as a complex with CBP and is required for transcriptional ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef6782a02fd12c20d85ec68ffd3a3fe
https://doi.org/10.1038/42652
https://doi.org/10.1038/42652
Autor:
Stefan Westin, Agneta Mode, Paul T. van der Saag, Edwin Sonneveld, Bas Jan M Van Der Leede, Jan-Åke Gustafsson
Publikováno v:
Molecular and Cellular Endocrinology. 129:169-179
Rats deficient in vitamin A express low levels of P4502C7 mRNA in the liver. Administration of all-trans retinoic acid (at-RA) or growth hormone (GH) to deficient animals only partially restored the expression whereas the combined treatment returned
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0bb9ff21c29e91888b01ef556bdd522
https://doi.org/10.1016/s0303-7207(97)04055-0
https://doi.org/10.1016/s0303-7207(97)04055-0
Publikováno v:
Biochemistry. 30:10844-10849
The male-specific CYP2C13 gene has been isolated from two independent rat genomic libraries. This gene spans more than 50 kb and contains eight introns which are subject to the GT-AG rule. Two allelic forms of the CYP2C13 gene were identified. Determ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb5573546ec1e9406a4dbba18c6c01b4
https://doi.org/10.1021/bi00109a006
https://doi.org/10.1021/bi00109a006
Publikováno v:
Gastroenterology. 148:S-856
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::af1f95332816e958b59249a453ab7dc6
https://doi.org/10.1016/s0016-5085(15)32899-7
https://doi.org/10.1016/s0016-5085(15)32899-7
Publikováno v:
Gastroenterology. 148:S-852
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ddf94f8dc12bc868d3938eb2767be88
https://doi.org/10.1016/s0016-5085(15)32889-4
https://doi.org/10.1016/s0016-5085(15)32889-4