Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Stefan Weger"'
Autor:
Julia S. Steinhoff, Carina Wagner, Ulrike Taschler, Sascha Wulff, Marie F. Kiefer, Konstantin M. Petricek, Sylvia J. Wowro, Moritz Oster, Roberto E. Flores, Na Yang, Chen Li, Yueming Meng, Manuela Sommerfeld, Stefan Weger, Andrea Henze, Jens Raila, Achim Lass, Michael Schupp
Publikováno v:
Journal of Lipid Research, Vol 63, Iss 10, Pp 100268- (2022)
Hepatocytes secrete retinol-binding protein 4 (RBP4) into circulation, thereby mobilizing vitamin A from the liver to provide retinol for extrahepatic tissues. Obesity and insulin resistance are associated with elevated RBP4 levels in the blood. Howe
Externí odkaz:
https://doaj.org/article/3e03abb6a7e44542a7029ef73356845c
Autor:
Stefan Weger
Publikováno v:
Viruses, Vol 15, Iss 1, p 64 (2022)
The successful application of recombinant adeno-associated virus (rAAV) vectors for long-term transgene expression in clinical studies requires scalable production methods with genetically stable components. Due to their simple production scheme and
Externí odkaz:
https://doaj.org/article/f9328b85c77843f483ba0ad162cd8a6a
Autor:
Catrin Stutika, Mario Mietzsch, Andreas Gogol-Döring, Stefan Weger, Madlen Sohn, Wei Chen, Regine Heilbronn
Publikováno v:
PLoS ONE, Vol 11, Iss 9, p e0161454 (2016)
Most DNA viruses express small regulatory RNAs, which interfere with viral or cellular gene expression. For adeno-associated virus (AAV), a small ssDNA virus with a complex biphasic life cycle miRNAs or other small regulatory RNAs have not yet been d
Externí odkaz:
https://doaj.org/article/d2713c58ea904d12a7e5e3628cdb3622
Autor:
Daniela Hüser, Andreas Gogol-Döring, Timo Lutter, Stefan Weger, Kerstin Winter, Eva-Maria Hammer, Toni Cathomen, Knut Reinert, Regine Heilbronn
Publikováno v:
PLoS Pathogens, Vol 6, Iss 7, p e1000985 (2010)
Adeno-associated virus type 2 (AAV) is known to establish latency by preferential integration in human chromosome 19q13.42. The AAV non-structural protein Rep appears to target a site called AAVS1 by simultaneously binding to Rep-binding sites (RBS)
Externí odkaz:
https://doaj.org/article/eb0261c9c280413a82730aee381124c9
Autor:
Steffi Heidenreich, Stefan Weger, Naomi Kast, Manuela Sommerfeld, Ronja Fedders, Michael Schupp, Sarah M. Kedziora, Andrea Henze, Miriam Knauer, Jens Raila, Pamela Weber, Matthias Muenzner
Publikováno v:
Journal of Biological Chemistry. 293:15269-15276
Retinol-binding protein 4 (RBP4) is the major transport protein for retinol in blood. Recent evidence from genetic mouse models shows that circulating RBP4 derives exclusively from hepatocytes. Because RBP4 is elevated in obesity and associates with
Publikováno v:
Journal of Virology. 90:3981-3993
Adeno-associated virus (AAV) has long been known to inhibit helper adenovirus (Ad) replication independently of AAV Rep protein expression. More recently, replication of Ad serotype 5 (Ad5)/AAV serotype 2 (AAV-2) hybrid vectors was shown to be inhibi
Autor:
Mario Mietzsch, Catrin Stutika, Laura Botschen, Stefan Weger, Regine Heilbronn, Wei Chen, Mirjam Feldkamp, Andreas Gogol-Döring
Publikováno v:
Journal of Virology. 90:1278-1289
Adeno-associated virus (AAV) is recognized for its bipartite life cycle with productive replication dependent on coinfection with adenovirus (Ad) and AAV latency being established in the absence of a helper virus. The shift from latent to Ad-dependen
Publikováno v:
Human Gene Therapy. 26:688-697
Scalable production of recombinant adeno-associated virus vectors (rAAV) in baculovirus-infected Sf9 cells yields high burst sizes but variable infectivity rates per packaged AAV vector genome depending on the chosen serotype. Infectivity rates are p
Publikováno v:
Journal of General Virology. 96:840-850
Adeno-associated virus (AAV) type 5 represents the genetically most distant AAV serotype and the only one isolated directly from human tissue. Seroepidemiological evidence suggests herpes simplex virus (HSV) as a helper virus for human AAV5 infection
Publikováno v:
The Journal of Neuroscience