Differential roles of STAT1 and STAT2 in the sensitivity of JAK2V617F- vs. BCR-ABL-positive cells to interferon alpha

Autor: Claudia Schubert, Manuel Allhoff, Stefan Tillmann, Tiago Maié, Ivan G. Costa, Daniel B. Lipka, Mirle Schemionek, Kristina Feldberg, Julian Baumeister, Tim H. Brümmendorf, Nicolas Chatain, Steffen Koschmieder

Publikováno v: Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-16 (2019)

Abstract Background Interferon alpha (IFNa) monotherapy is recommended as the standard therapy in polycythemia vera (PV) but not in chronic myeloid leukemia (CML). Here, we investigated the mechanisms of IFNa efficacy in JAK2V617F- vs. BCR-ABL-positi

Externí odkaz: https://doaj.org/article/f04572cd8a7a47c1b8bb12f8129e168b

The Unfolded Protein Response Is a Major Driver of LCN2 Expression in BCR–ABL- and JAK2V617F-Positive MPN

Autor: Susanne Isfort, Vera Kathrin Preußger, Ralf Weiskirchen, Walter Becker, Tim H. Brümmendorf, Kim Kricheldorf, Marlena Bütow, Stefan Tillmann, Mirle Schemionek, Blanka Kubešová, Nicolas Chatain, Jörg Eschweiler, Steffen Koschmieder, Martina Wessiepe, Barbora Weinbergerova, Jiri Mayer, Kathrin Olschok, Sarah K. Schröder, Milena Kalmer, Julian Baumeister, Zdenek Racil

Publikováno v: Cancers
Cancers, Vol 13, Iss 4210, p 4210 (2021)
Cancers 13(16), 4210 (2021). doi:10.3390/cancers13164210 special issue: "Special Issue "Pathogenesis and Natural History of Myeloproliferative Neoplasms" / Special Issue Editor: Marco Pizzi, Guest Editor"
Volume 13
Issue 16

Lipocalin 2 (LCN2), a proinflammatory mediator, is involved in the pathogenesis of myeloproliferative neoplasms (MPN). Here, we investigated the molecular mechanisms of LCN2 overexpression in MPN. LCN2 mRNA expression was 20-fold upregulated in perip

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b68400919e4bc9ee410a046fcf37d1

The Unfolded Protein Response Mediates Resistance in AML and Its Therapeutic Targeting Enhances TKI Induced Cell Death in FLT3-ITD + AML

Autor: Michael Huber, Steffen Koschmieder, Timo Jaquet, Edgar Jost, Iris Appelmann, Marlena Bütow, Mirle Schemionek, Stefan Tillmann, Martin Kirschner, Nicolas Chatain, Tim H. Brümmendorf, Bezhad Kharabi, Christian Preisinger

Publikováno v: Blood. 138:2246-2246

Introduction: The unfolded protein response (UPR) is a stress sensing signaling network that is activated upon endoplasmic reticulum (ER) stress, a condition characterized by an accumulation of mis- and unfolded proteins in the ER. To retain a functi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a2aa025d89b27a04f081d561b0b0ba58
https://doi.org/10.1182/blood-2021-150066

TNF-α controls Lipocalin-2 expression in PC-3 prostate cancer cells

Autor: Anastasia Asimakopoulou, Stefan Tillmann, Steffen Koschmieder, Ralf Weiskirchen, Sarah K. Schröder

Publikováno v: Cytokine. 135:155214

Prostate cancer (PCa) is one of the most common and deadly cancers in men worldwide. The surrounding tumor microenvironment (TME) is important in tumor progression, as cytokines and soluble mediators including tumor necrosis factor (TNF-α) or lipoca

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03b0bc0a99cfdb3af9c827dd1d33000d
https://doi.org/10.1016/j.cyto.2020.155214

O005 Platelet expression of MIF and its secretion by thrombogenic stimulation

Autor: T. Strüßmann, Theresa H. Wirtz, Jürgen Bernhagen, Stefan Tillmann

Publikováno v: Cytokine. 59:499

Introduction Atherosclerosis, a chronic inflammatory disease of the arterial wall, is the main underlying pathology of cardiovascular diseases in the Western world. Chemokines in conjunction with leukocytes recruited into the atherogenic vessel wall

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8653eb71599eab2a8a4d3781c7b8ad18
https://doi.org/10.1016/j.cyto.2012.06.032