Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Stefan Thiem"'
Autor:
Anne Huber, Amr H. Allam, Christine Dijkstra, Stefan Thiem, Jennifer Huynh, Ashleigh R. Poh, Joshua Konecnik, Saumya P. Jacob, Rita Busuttil, Yang Liao, David Chisanga, Wei Shi, Mariah G. Alorro, Stephen Forrow, Daniele V.F. Tauriello, Eduard Batlle, Alex Boussioutas, David S. Williams, Michael Buchert, Matthias Ernst, Moritz F. Eissmann
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114616- (2024)
Summary: Although aberrant activation of the KRAS and PI3K pathway alongside TP53 mutations account for frequent aberrations in human gastric cancers, neither the sequence nor the individual contributions of these mutations have been clarified. Here,
Externí odkaz:
https://doaj.org/article/bcbb4c19d532433d8228119f5febdeda
Autor:
Moritz F. Eissmann, Christine Dijkstra, Andrew Jarnicki, Toby Phesse, Jamina Brunnberg, Ashleigh R. Poh, Nima Etemadi, Evelyn Tsantikos, Stefan Thiem, Nicholas D. Huntington, Margaret L. Hibbs, Alex Boussioutas, Michele A. Grimbaldeston, Michael Buchert, Robert J. J. O’Donoghue, Frederick Masson, Matthias Ernst
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
Mast cells within the tumor microenvironment have controversial roles. Here, the authors show, using genetic mouse models, that in gastric cancer, mast cells at the periphery of the tumors are activated via cancer cell produced-IL33 and promote tumor
Externí odkaz:
https://doaj.org/article/358dfe59c0ac41659d29059d99a2f0be
Autor:
Robert J. J. O'Donoghue, Darryl A. Knight, Carl D. Richards, Cecilia M. Prêle, Hui Ling Lau, Andrew G. Jarnicki, Jessica Jones, Steven Bozinovski, Ross Vlahos, Stefan Thiem, Brent S. McKenzie, Bo Wang, Philip Stumbles, Geoffrey J. Laurent, Robin J. McAnulty, Stefan Rose‐John, Hong Jian Zhu, Gary P. Anderson, Matthias R. Ernst, Steven E. Mutsaers
Publikováno v:
EMBO Molecular Medicine, Vol 4, Iss 9, Pp 939-951 (2012)
Abstract Idiopathic pulmonary fibrosis (IPF) is a fatal disease that is unresponsive to current therapies and characterized by excessive collagen deposition and subsequent fibrosis. While inflammatory cytokines, including interleukin (IL)‐6, are el
Externí odkaz:
https://doaj.org/article/bc3bb7468c6647178e64c5cfbda37d78
Autor:
Christian J. Sander, Stefan Thiem
Publikováno v:
Research in Economics. 77:122-130
There is a lively debate on whether football fans should pay an additional security fee, added to the price of tickets, to finance police activities on match days. This paper investigates the price effect on the demand for tickets in a dynamic settin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b16787f10e4444f88b32fd831318e82b
https://doi.org/10.1016/j.rie.2023.01.006
https://doi.org/10.1016/j.rie.2023.01.006
Autor:
Matthias Ernst, Toby J. Phesse, Paul M. Waring, Dennis Huszar, Joachim Elzer, Ryan Farid, Stefan Thiem, Tracy Putoczki, Michael Buchert, Emma Stuart
Aberrant activation of the latent transcription factor STAT3 and its downstream targets is a common feature of epithelial-derived human cancers, including those of the gastrointestinal tract. Mouse models of gastrointestinal malignancy implicate Stat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6909aa57204ed9c2ae2994aa98111eb
https://doi.org/10.1158/1535-7163.c.6536220
https://doi.org/10.1158/1535-7163.c.6536220
Autor:
Matthias Ernst, Toby J. Phesse, Paul M. Waring, Dennis Huszar, Joachim Elzer, Ryan Farid, Stefan Thiem, Tracy Putoczki, Michael Buchert, Emma Stuart
PDF file - 141K, Table S1. Primers used for quantitative PCR analysis. Table S2. Antibodies (all diluted 1:1000) used for immunohistochemistry and Western Blot analysis.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::08d12f167ae93b1870534adbf94ce267
https://doi.org/10.1158/1535-7163.22499691.v1
https://doi.org/10.1158/1535-7163.22499691.v1
Autor:
Matthias Ernst, Toby J. Phesse, Paul M. Waring, Dennis Huszar, Joachim Elzer, Ryan Farid, Stefan Thiem, Tracy Putoczki, Michael Buchert, Emma Stuart
PDF file - 1978K, Supplementary Figure 1: The gpA33 locus confers expression of tamoxifen-activatable CreERT2 transgene to the metaplastic epithelium of gastric tumors of gp130F/F mice. Supplementary Figure 2: AZD1480-treatment reduces gastric tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::307e6924354e7af1c4dec54090432fdb
https://doi.org/10.1158/1535-7163.22499688.v1
https://doi.org/10.1158/1535-7163.22499688.v1
Autor:
Matthias Ernst, Andrew Jarnicki, Michael Buchert, Paul Waring, Elizabeth Vincan, Dustin Flanagan, Adele Preaudet, Paul Nguyen, Ashleigh Poh, Tracy L. Putoczki, Anna Jonas, Joachim Elzer, Moritz F. Eissmann, Stefan Thiem
Additional supportive data is provided as Fig S1 (Generation and validation of Tg(Tff1-CreERT2)mice), Fig. S2 (Tff1-CreERT2 transgene, endogenous Tff1, and Lgr5 expression in the stomach), Fig. S3 (Tff1-CreERT2-mediated I2-galactosidase reporter acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5db58749ea853631dd212165e98a4551
https://doi.org/10.1158/0008-5472.22413366
https://doi.org/10.1158/0008-5472.22413366
Autor:
Matthias Ernst, Andrew Jarnicki, Michael Buchert, Paul Waring, Elizabeth Vincan, Dustin Flanagan, Adele Preaudet, Paul Nguyen, Ashleigh Poh, Tracy L. Putoczki, Anna Jonas, Joachim Elzer, Moritz F. Eissmann, Stefan Thiem
About 5% to 10% of human gastric tumors harbor oncogenic mutations in the KRAS pathway, but their presence alone is often insufficient for inducing gastric tumorigenesis, suggesting a requirement for additional mutagenic events or microenvironmental
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6a0282bb46fcdb94c50b17a35115db3
https://doi.org/10.1158/0008-5472.c.6508698.v1
https://doi.org/10.1158/0008-5472.c.6508698.v1
Autor:
Matthias Ernst, Andrew Jarnicki, Michael Buchert, Paul Waring, Elizabeth Vincan, Dustin Flanagan, Adele Preaudet, Paul Nguyen, Ashleigh Poh, Tracy L. Putoczki, Anna Jonas, Joachim Elzer, Moritz F. Eissmann, Stefan Thiem
Supplementary Figure Legends
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99fa2cc741cf7496103e71fbb24f62ea
https://doi.org/10.1158/0008-5472.22413369
https://doi.org/10.1158/0008-5472.22413369