Zobrazeno 1 - 10
of 78
pro vyhledávání: '"Stefan Steinbacher"'
Autor:
Paul Beroza, James J. Crawford, Oleg Ganichkin, Leo Gendelev, Seth F. Harris, Raphael Klein, Anh Miu, Stefan Steinbacher, Franca-Maria Klingler, Christian Lemmen
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Virtual screening of huge libraries is successful in identifying drug leads. Here, the authors describe a computational strategy, Chemical Space Docking, which combines docking with a reaction-based search of compounds, thereby enabling the explorati
Externí odkaz:
https://doaj.org/article/92730f41f1224e6e9e787ec4095a9009
Autor:
Jeroen van Ameijde, Rosa Crespo, Roosmarijn Janson, Jarek Juraszek, Berdien Siregar, Hanneke Verveen, Imke Sprengers, Tariq Nahar, Jeroen J. Hoozemans, Stefan Steinbacher, Roland Willems, Lore Delbroek, Marianne Borgers, Koen Dockx, Kristof Van Kolen, Marc Mercken, Gabriel Pascual, Wouter Koudstaal, Adrian Apetri
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Abstract Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy. We have
Externí odkaz:
https://doaj.org/article/953e8ff91c8e4f18bdde6ccba2569d9c
Autor:
Adrian Apetri, Rosa Crespo, Jarek Juraszek, Gabriel Pascual, Roosmarijn Janson, Xueyong Zhu, Heng Zhang, Elissa Keogh, Trevin Holland, Jay Wadia, Hanneke Verveen, Berdien Siregar, Michael Mrosek, Renske Taggenbrock, Jeroenvan Ameijde, Hanna Inganäs, Margot van Winsen, Martin H. Koldijk, David Zuijdgeest, Marianne Borgers, Koen Dockx, Esther J. M. Stoop, Wenli Yu, Els C. Brinkman-van der Linden, Kimberley Ummenthum, Kristof van Kolen, Marc Mercken, Stefan Steinbacher, Donata de Marco, Jeroen J. Hoozemans, Ian A. Wilson, Wouter Koudstaal, Jaap Goudsmit
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-17 (2018)
Abstract Misfolding and aggregation of tau protein are closely associated with the onset and progression of Alzheimer’s Disease (AD). By interrogating IgG+ memory B cells from asymptomatic donors with tau peptides, we have identified two somaticall
Externí odkaz:
https://doaj.org/article/c0395ac19eb24ba4951a4cf53142723b
Autor:
Tomoe Kitao, Francois Lepine, Seda Babloudi, Frederick Walte, Stefan Steinbacher, Klaus Maskos, Michael Blaesse, Michele Negri, Michael Pucci, Bob Zahler, Antonio Felici, Laurence G. Rahme
Publikováno v:
mBio, Vol 9, Iss 1 (2018)
ABSTRACT New approaches to antimicrobial drug discovery are urgently needed to combat intractable infections caused by multidrug-resistant (MDR) bacteria. Multiple virulence factor regulator (MvfR or PqsR), a Pseudomonas aeruginosa quorum sensing tra
Externí odkaz:
https://doaj.org/article/3a5377cb41f442beb617a5562a681113
Autor:
Tammy Ladduwahetty, Matthew R. Lee, Michel C. Maillard, Roger Cachope, Daniel Todd, Michael Barnes, Vahri Beaumont, Alka Chauhan, Caroline Gallati, Alan F. Haughan, Georg Kempf, Christopher A. Luckhurst, Kim Matthews, George McAllister, Philip Mitchell, Hiral Patel, Mark Rose, Elizabeth Saville-Stones, Stefan Steinbacher, Andrew J. Stott, Emma Thatcher, Jason Tierney, Liudvikas Urbonas, Ignacio Munoz-Sanjuan, Celia Dominguez
Publikováno v:
Journal of medicinal chemistry. 65(14)
The Rho kinase (ROCK) pathway is implicated in the pathogenesis of several conditions, including neurological diseases. In Huntington's disease (HD), ROCK is implicated in mutant huntingtin (HTT) aggregation and neurotoxicity, and members of the ROCK
Autor:
Eric T. Baldwin, Matthias Götte, Egor P. Tchesnokov, Eddy Arnold, Margit Hagel, Charles Nichols, Pam Dossang, Marieke Lamers, Paul Wan, Stefan Steinbacher, Donna L. Romero
Publikováno v:
Proceedings of the National Academy of Sciences. 119
Human endogenous retroviruses (HERVs) comprise nearly 8% of the human genome and are derived from ancient integrations of retroviruses into the germline. The biology of HERVs is poorly defined, but there is accumulating evidence supporting pathologic
Autor:
Georg Kempf, Ignacio Munoz-Sanjuan, Alexandros Patsilinakos, Matteo Andreini, Stefania Colarusso, Vincenzo Summa, Jesus Maria Ontoria Ontoria, Federica Ferrigno, Paola Fezzardi, Steven J. Harper, Leticia Toledo Sherman, Stefan Steinbacher, Ilaria Biancofiore, Esther Torrente, Martin Augustin, Elisabetta Bianchi, Larry Park, Alberto Bresciani, Robert Pacifici, Celia Dominguez
Publikováno v:
ACS Med Chem Lett
[Image: see text] The NRF2-ARE pathway is an intrinsic mechanism of defense against oxidative stress. Inhibition of the interaction between NRF2 and its main negative regulator KEAP1 is an attractive strategy toward neuroprotective agents. We report
Autor:
Paul Beroza, James J. Crawford, Oleg Ganichkin, Leo Gendelev, Seth F. Harris, Raphael Klein, Anh Miu, Stefan Steinbacher, Franca-Maria Klingler, Christian Lemmen
Publikováno v:
Nature communications. 13(1)
With the ever-increasing number of synthesis-on-demand compounds for drug lead discovery, there is a great need for efficient search technologies. We present the successful application of a virtual screening method that combines two advances: (1) it
Autor:
Ena Ladi, Matthew R. Durk, Craig Stivala, Michael Blaesse, Malcolm P. Huestis, Seth F. Harris, Daniels Blake, Christine Everett, Rajita Pappu, Stefan Steinbacher, Martin Augustin, Steven T. Staben, Michael Siu, Hans E. Purkey, Celine Eidenschenk
Publikováno v:
Journal of Medicinal Chemistry. 62:7032-7041
The pan-proteasome inhibitor bortezomib demonstrated clinical efficacy in off-label trials of Systemic Lupus Erythematosus. One potential mechanism of this clinical benefit is from the depletion of pathogenic immune cells (plasmablasts and plasmacyto
Autor:
Marianne Borgers, Jeroen J.M. Hoozemans, Roosmarijn Janson, Jarek Juraszek, Lore Delbroek, Berdien Siregar, Marc Mercken, Imke Sprengers, Adrian Apetri, Jeroen van Ameijde, Roland Willems, Kristof Van Kolen, Wouter Koudstaal, Koen Dockx, Gabriel Pascual, Tariq Nahar, Hanneke Verveen, Stefan Steinbacher, Rosa Crespo
Publikováno v:
Acta Neuropathologica Communications, Vol 6, Iss 1, Pp 1-14 (2018)
Acta Neuropathologica Communinications, 6(1):59. BioMed Central
Acta Neuropathologica Communications
van Ameijde, J, Crespo, R, Janson, R, Juraszek, J, Siregar, B, Verveen, H, Sprengers, I, Nahar, T, Hoozemans, J J, Steinbacher, S, Willems, R, Delbroek, L, Borgers, M, Dockx, K, van Kolen, K, Mercken, M, Pascual, G, Koudstaal, W & Apetri, A 2018, ' Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser 422 containing epitope on pathological tau ', Acta Neuropathologica Communinications, vol. 6, no. 1, 59 . https://doi.org/10.1186/s40478-018-0562-9, https://doi.org/10.1186/s40478-018-0562-9
Acta Neuropathologica Communinications, 6(1):59. BioMed Central
Acta Neuropathologica Communications
van Ameijde, J, Crespo, R, Janson, R, Juraszek, J, Siregar, B, Verveen, H, Sprengers, I, Nahar, T, Hoozemans, J J, Steinbacher, S, Willems, R, Delbroek, L, Borgers, M, Dockx, K, van Kolen, K, Mercken, M, Pascual, G, Koudstaal, W & Apetri, A 2018, ' Enhancement of therapeutic potential of a naturally occurring human antibody targeting a phosphorylated Ser 422 containing epitope on pathological tau ', Acta Neuropathologica Communinications, vol. 6, no. 1, 59 . https://doi.org/10.1186/s40478-018-0562-9, https://doi.org/10.1186/s40478-018-0562-9
Aggregation of tau protein and spreading of tau aggregates are pivotal pathological processes in a range of neurological disorders. Accumulating evidence suggests that immunotherapy targeting tau may be a viable therapeutic strategy. We have previous