Zobrazeno 1 - 10
of 573
pro vyhledávání: '"Stefan Sleijfer"'
Autor:
Noortje Verschoor, Marcel Smid, Agnes Jager, Stefan Sleijfer, Saskia M. Wilting, John W. M. Martens
Publikováno v:
Breast Cancer Research, Vol 25, Iss 1, Pp 1-12 (2023)
Abstract Background In breast cancer, the advent of anti-HER2 therapies has made HER2+ tumors a highly relevant subgroup. However, the exact characteristics which prohibit clinical response to anti-HER2 therapies and drive disease progression are not
Externí odkaz:
https://doaj.org/article/eb68c979d7994380af5986176e6bfa77
Autor:
Noortje Verschoor, Vanja de Weerd, Mai N. Van, Jaco Kraan, Marcel Smid, Joan B. Heijns, Jan C. Drooger, Johanna M. Zuetenhorst, Annemieke van der Padt-Pruijsten, Agnes Jager, Stefan Sleijfer, John W. M. Martens, Saskia M. Wilting
Publikováno v:
npj Breast Cancer, Vol 9, Iss 1, Pp 1-7 (2023)
Abstract This prospective cohort study reports aneuploidy score by mFast-SeqS as a strong prognostic marker in MBC patients. mFAST-SeqS is an affordable and easily implementable method for the assessment of total ctDNA levels and, as such, provides a
Externí odkaz:
https://doaj.org/article/a91a32dd499f413bab3e0ca153172941
Autor:
Anne‐Rose W. Schut, Leanne E. deBruin, Belle H. deRooij, Emma Lidington, Milea J. M. Timbergen, Winette T. A. van derGraaf, Winan J. vanHoudt, Johannes J. Bonenkamp, Robin L. Jones, Dirk. J. Grünhagen, Stefan Sleijfer, Spyridon Gennatas, Cornelis Verhoef, Olga Husson
Publikováno v:
Cancer Medicine, Vol 12, Iss 12, Pp 13661-13674 (2023)
Abstract Background Desmoid‐type fibromatosis (DTF) has a highly variable clinical course with varying intensity of symptoms. The objectives of this study were to identify subgroups of DTF patients based on physical symptom burden and to compare sy
Externí odkaz:
https://doaj.org/article/68c9dc77427e4ed09f0bee452795e1f3
Autor:
Delal Akdeniz, Iris Kramer, Carolien H. M. vanDeurzen, Bernadette A. M. Heemskerk‐Gerritsen, Michael Schaapveld, Pieter J. Westenend, Adri C. Voogd, Agnes Jager, Ewout W. Steyerberg, Stefan Sleijfer, Marjanka K. Schmidt, Maartje J. Hooning
Publikováno v:
Cancer Medicine, Vol 12, Iss 3, Pp 3123-3133 (2023)
Abstract Lobular primary breast cancer (PBC) histology has been proposed as a risk factor for contralateral breast cancer (CBC), but results have been inconsistent. We investigated CBC risk and the impact of systemic therapy in lobular versus ductal
Externí odkaz:
https://doaj.org/article/7d23a8a1a0284dc5a800b967820b1d06
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Rapid increase in cost continues to have negative impact on patients’ accessibility to life-changing anticancer medications. Moreover, the rising cost does not equate to similar increase in medication effectiveness. We recognise our responsibility
Externí odkaz:
https://doaj.org/article/e4a6dd88ff534b56b11188c5ffbb362b
Autor:
Teoman Deger, Pauline A. J. Mendelaar, Jaco Kraan, Wendy J. C. Prager‐van der Smissen, Michelle van derVlugt‐Daane, Eric M. J. Bindels, Anieta M. Sieuwerts, Stefan Sleijfer, Saskia M. Wilting, Antoinette Hollestelle, John W. M. Martens
Publikováno v:
Molecular Oncology, Vol 16, Iss 16, Pp 2981-3000 (2022)
Intrapatient tumour heterogeneity is likely a major determinant of clinical outcome in cancer patients. To assess heterogeneity in a minimally invasive manner, methods to perform single circulating tumour cell (CTC) genomics at high resolution are ne
Externí odkaz:
https://doaj.org/article/670fed1d4b0e407da90d1dd04df95007
Autor:
Wesley S. van de Geer, Ron H.J. Mathijssen, Job van Riet, Neeltje Steeghs, Mariette Labots, Carla van Herpen, Lot A. Devriese, Vivianne C.G. Tjan-Heijnen, Emile E. Voest, Stefan Sleijfer, John W.M. Martens, Edwin Cuppen, Harmen J.G. van de Werken, Sander Bins
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 159, Iss , Pp 114210- (2023)
Drug resistance is a perpetual problem in cancer therapy with many underlying mechanisms. Alterations in drug transport over the cancer cell membrane can severely alter intratumoral drug exposure, contributing to resistance. Here, we present the soma
Externí odkaz:
https://doaj.org/article/dfde034a6bb040089d45cdf4f8ef6c58
Autor:
Lindsay Angus, Marcel Smid, Saskia M. Wilting, Manouk K. Bos, Neeltje Steeghs, Inge R. H. M. Konings, Vivianne C. G. Tjan-Heijnen, Johanna M. G. H. van Riel, Agnes J. van de Wouw, CPCT Consortium, Edwin Cuppen, Martijn P. Lolkema, Agnes Jager, Stefan Sleijfer, John W. M. Martens
Publikováno v:
Cancers, Vol 15, Iss 17, p 4416 (2023)
Mutations in the estrogen receptor gene (ESR1), its transcriptional regulators, and the mitogen-activated protein kinase (MAPK) pathway are enriched in patients with endocrine-resistant metastatic breast cancer (MBC). Here, we integrated whole genome
Externí odkaz:
https://doaj.org/article/20cce45044e24c7984aa2046e7d671d0
Autor:
Silvia R. Vitale, Kirsten Ruigrok-Ritstier, A. Mieke Timmermans, Renée Foekens, Anita M. A. C. Trapman-Jansen, Corine M. Beaufort, Paolo Vigneri, Stefan Sleijfer, John W. M. Martens, Anieta M. Sieuwerts, Maurice P. H. M. Jansen
Publikováno v:
BMC Cancer, Vol 22, Iss 1, Pp 1-16 (2022)
Abstract Background In breast cancer (BC), recurrent fusion genes of estrogen receptor alpha (ESR1) and AKAP12, ARMT1 and CCDC170 have been reported. In these gene fusions the ligand binding domain of ESR1 has been replaced by the transactivation dom
Externí odkaz:
https://doaj.org/article/5619f8611366419781ebf77950eb8c5c
Autor:
Job van Riet, Harmen J. G. van de Werken, Edwin Cuppen, Ferry A. L. M. Eskens, Margot Tesselaar, Linde M. van Veenendaal, Heinz-Josef Klümpen, Marcus W. Dercksen, Gerlof D. Valk, Martijn P. Lolkema, Stefan Sleijfer, Bianca Mostert
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Metastatic and locally-advanced neuroendocrine neoplasms (aNEN) display heterogeneous clinical and genetic characteristics. Here, the authors investigate the mutational landscape of 85 aNEN by whole genome sequencing and identify distinct subpopulati
Externí odkaz:
https://doaj.org/article/c4e59c95fe6b477fbcc18e6c64953ba9