Zobrazeno 1 - 10
of 87
pro vyhledávání: '"Stefan Simm"'
Autor:
Christian Nitzsche, Stefan Simm
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-17 (2024)
Abstract In actual pandemic situations like COVID-19, it is important to understand the influence of single mitigation measures as well as combinations to create most dynamic impact for lockdown scenarios. Therefore we created an agent-based model (A
Externí odkaz:
https://doaj.org/article/7db61f80c3f74c5fb7cfce8db19d0d32
Autor:
Maryna Somova, Stefan Simm, Adventina Padmyastuti, Jens Ehrhardt, Janosch Schoon, Ingmar Wolff, Martin Burchardt, Cindy Roennau, Pedro Caetano Pinto
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-15 (2024)
Abstract The advent of micro-physiological systems (MPS) in biomedical research has enabled the introduction of more complex and relevant physiological into in vitro models. The recreation of complex morphological features in three-dimensional enviro
Externí odkaz:
https://doaj.org/article/c85c73dc57cb4e478f2a492b1044af8f
Zyxin is important for the stability and function of podocytes, especially during mechanical stretch
Autor:
Felix Kliewe, Florian Siegerist, Elke Hammer, Jaafar Al-Hasani, Theodor Rolf Jakob Amling, Jonas Zeno Eddy Hollemann, Maximilian Schindler, Vedran Drenic, Stefan Simm, Kerstin Amann, Christoph Daniel, Maja Lindenmeyer, Markus Hecker, Uwe Völker, Nicole Endlich
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-14 (2024)
Abstract Podocyte detachment due to mechanical stress is a common issue in hypertension-induced kidney disease. This study highlights the role of zyxin for podocyte stability and function. We have found that zyxin is significantly up-regulated in pod
Externí odkaz:
https://doaj.org/article/aeac6a2a22ce4682a2efff53ba47a07d
Autor:
Maryna Somova, Stefan Simm, Adventina Padmyastuti, Jens Ehrhardt, Janosch Schoon, Ingmar Wolf, Martin Burchardt, Cindy Roennau, Pedro Caetano Pinto
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-1 (2024)
Externí odkaz:
https://doaj.org/article/71f44811b0334dbfa1540b7252055865
Autor:
Niclas Fester, Elisabeth Zielonka, Jakob Goldmann, Ann-Sophie Frombach, Uta Müller-Kuller, Niklas Gutfreund, Kristina Riegel, Jos G. A. Smits, Enrico Schleiff, Krishnaraj Rajalingam, Huiqing Zhou, Stefan Simm, Volker Dötsch
Publikováno v:
Cell Death and Disease, Vol 13, Iss 3, Pp 1-10 (2022)
Abstract Specialized surveillance mechanisms are essential to maintain the genetic integrity of germ cells, which are not only the source of all somatic cells but also of the germ cells of the next generation. DNA damage and chromosomal aberrations a
Externí odkaz:
https://doaj.org/article/841bc32e7e0f40afa499d067f945af6a
Autor:
Hannes Forkel, Piotr Grabarczyk, Maren Depke, Sascha Troschke-Meurer, Stefan Simm, Elke Hammer, Stephan Michalik, Christian Hentschker, Björn Corleis, Lucie Loyal, Maxi Zumpe, Nikolai Siebert, Anca Dorhoi, Andreas Thiel, Holger Lode, Uwe Völker, Christian A. Schmidt
Publikováno v:
OncoImmunology, Vol 11, Iss 1 (2022)
ABSTRACTBCL11B, an essential transcription factor for thymopoiesis, regulates also vital processes in post-thymic lymphocytes. Increased expression of BCL11B was recently correlated with the maturation of NK cells, whereas reduced BCL11B levels were
Externí odkaz:
https://doaj.org/article/38c9a1f16c6741208dbf26b7a38a18f3
Autor:
Gayatri Jagirdar, Matthias Elsner, Christian Scharf, Stefan Simm, Katrin Borucki, Daniela Peter, Michael Lalk, Karen Methling, Michael Linnebacher, Mathias Krohn, Carmen Wolke, Uwe Lendeckel
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Externí odkaz:
https://doaj.org/article/6902018728e4466e9ce6c119e600b505
Autor:
Gayatri Jagirdar, Matthias Elsner, Christian Scharf, Stefan Simm, Katrin Borucki, Daniela Peter, Michael Lalk, Karen Methling, Michael Linnebacher, Mathias Krohn, Carmen Wolke, Uwe Lendeckel
Publikováno v:
Frontiers in Genetics, Vol 13 (2022)
Tafazzin—an acyltransferase—is involved in cardiolipin (CL) remodeling. CL is associated with mitochondrial function, structure and more recently with cell proliferation. Various tafazzin isoforms exist in humans. The role of these isoforms in ca
Externí odkaz:
https://doaj.org/article/ccfbeaf0a01a4f44a636a95043149365
Publikováno v:
Frontiers in Plant Science, Vol 13 (2022)
Alternative splicing (AS) is a major mechanism for gene expression in eukaryotes, increasing proteome diversity but also regulating transcriptome abundance. High temperatures have a strong impact on the splicing profile of many genes and therefore AS
Externí odkaz:
https://doaj.org/article/0a6022b97e8141538184a0c15c4e0f3b
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 8884 (2023)
Non-coding RNA (ncRNA) classes take over important housekeeping and regulatory functions and are quite heterogeneous in terms of length, sequence conservation and secondary structure. High-throughput sequencing reveals that the expressed novel ncRNAs
Externí odkaz:
https://doaj.org/article/42d559e25f7d498d85612b1c4fa7f679