Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Stefan Schiesser"'
Autor:
Stefan Schiesser, Joanna Ceklarz, Johanna Kollback, Lucie Borowiec, Julia Fagerlund, Shakiba Vahdat, Marika Lindhagen, Okky Dwichandra Putra
Publikováno v:
Chemistry – A European Journal.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::51aac67f26e14e8eab74d741f21145c9
https://doi.org/10.1002/chem.202301421
https://doi.org/10.1002/chem.202301421
Publikováno v:
Progress in medicinal chemistry. 61
Inhalation of small molecule drugs has proven very efficacious for the treatment of respiratory diseases due to enhanced efficacy and a favourable therapeutic index compared with other dosing routes. It enables targeted delivery to the lung with rapi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::49086127f9b6aaf6491436698570f6c4
https://pubmed.ncbi.nlm.nih.gov/35753716
https://pubmed.ncbi.nlm.nih.gov/35753716
Publikováno v:
Future Drug Discovery. 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e61e9ad50562796e8b77b5a034f9151b
https://doi.org/10.4155/fdd-2022-0009
https://doi.org/10.4155/fdd-2022-0009
Autor:
Peter Sjö, Vasanthanathan Poongavanam, Stefan Geschwindner, Fabio Begnini, Björn Over, Stefan Schiesser, Jan Kihlberg, Patrik Johansson, Lisa Wissler, Mohit Tyagi, Christian Tyrchan, Marie Castaldo
Publikováno v:
Journal of Medicinal Chemistry
'Journal of Medicinal Chemistry ', vol: 64, pages: 1054-1072 (2021)
'Journal of Medicinal Chemistry ', vol: 64, pages: 1054-1072 (2021)
Lead generation for difficult-to-drug targets that have large, featureless, and highly lipophilic or highly polar and/or flexible binding sites is highly challenging. Here, we describe how cores of macrocyclic natural products can serve as a high-qua
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::576ecb3e7caf5e6bea9841c231a8bec6
http://europepmc.org/articles/PMC7872424
http://europepmc.org/articles/PMC7872424
Autor:
Johanna Kollback, Stefan Schiesser, Rhona J. Cox, Thibaut Quennesson, Hanna Chepliaka, Werngard Czechtizky
Publikováno v:
Journal of Medicinal Chemistry. 63:13076-13089
Introducing trifluoromethyl groups is a common strategy to improve the properties of biologically active compounds. However, N-trifluoromethyl moieties on amines and azoles are very rarely used. To evaluate their suitability in drug design, we synthe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::63b3706b17a00bab0b43c999da7b1e91
https://doi.org/10.1021/acs.jmedchem.0c01457
https://doi.org/10.1021/acs.jmedchem.0c01457
Publikováno v:
Progress in Medicinal Chemistry ISBN: 9780323989039
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c704d04fd07af68aa286e370944ae0aa
https://doi.org/10.1016/bs.pmch.2022.04.001
https://doi.org/10.1016/bs.pmch.2022.04.001
Autor:
Fabio Begnini, Stefan Geschwindner, Patrik Johansson, Lisa Wissler, Richard J. Lewis, Emma Danelius, Andreas Luttens, Pierre Matricon, Jens Carlsson, Stijn Lenders, Beate König, Anna Friedel, Peter Sjö, Stefan Schiesser, Jan Kihlberg
Upregulation of the transcription factor Nrf2 by inhibition of the interaction with its negative regulator Keap1 constitutes an opportunity for the treatment of disease caused by oxidative stress. We report a structurally unique series of nanomolar K
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2356a884998258f24d9f2fdfe2f58424
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-477522
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-477522
Autor:
Fabio Begnini, Stefan Geschwindner, Patrik Johansson, Lisa Wissler, Richard J. Lewis, Emma Danelius, Andreas Luttens, Pierre Matricon, Jens Carlsson, Stijn Lenders, Beate König, Anna Friedel, Peter Sjö, Stefan Schiesser, Jan Kihlberg
Publikováno v:
Journal of Medicinal Chemistry. 66:2204-2204
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f270108906b18f03ab1dfe94fdd9e6f
https://doi.org/10.1021/acs.jmedchem.3c00037
https://doi.org/10.1021/acs.jmedchem.3c00037
Publikováno v:
European journal of medicinal chemistry. 227
Inhibition of mucosa-associated lymphoid tissue lymphoma translocation protein-1 (MALT1) is a promising strategy to modulate NF-κB signaling, with the potential to treat B-cell lymphoma and autoimmune diseases. We describe the discovery and optimiza
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5085d83f97e829c60839c3e4117e20f6
https://pubmed.ncbi.nlm.nih.gov/34742013
https://pubmed.ncbi.nlm.nih.gov/34742013