Zobrazeno 1 - 10 of 24 pro vyhledávání: '"Stefan Schefczyk"'
1
Akademický článek
Hepatitis B surface antigen expression impairs endoplasmic reticulum stress-related autophagic flux by decreasing LAMP2
Autor: Yaojie Liang, Xufeng Luo, Stefan Schefczyk, Lorraine T. Muungani, Hui Deng, Baoju Wang, Hideo A. Baba, Mengji Lu, Heiner Wedemeyer, Hartmut H. Schmidt, Ruth Broering
Publikováno v: JHEP Reports, Vol 6, Iss 4, Pp 101012- (2024)
Background & Aims: Hepatitis B surface antigen (HBsAg) drives hepatocarcinogenesis. Factors and mechanisms involved in this progression remain poorly defined, hindering the development of effective therapeutic strategies. Therefore, the mechanisms in
Externí odkaz: https://doaj.org/article/021c294eb0fa4e82a3c04f7fbcee6c73
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2
Akademický článek
Tg1.4HBV-s-rec mice, a crossbred hepatitis B virus-transgenic model, develop mild hepatitis
Autor: Stefan Schefczyk, Xufeng Luo, Yaojie Liang, Mike Hasenberg, Bernd Walkenfort, Martin Trippler, Jonas Schuhenn, Kathrin Sutter, Mengji Lu, Heiner Wedemeyer, Hartmut H. Schmidt, Ruth Broering
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract Hepatitis B virus (HBV)-transgenic mice exhibit competent innate immunity and are therefore an ideal model for considering intrinsic or cell-based mechanisms in HBV pathophysiology. A highly replicative model that has been little used, let a
Externí odkaz: https://doaj.org/article/d8033cbdd44a4c2e8375ba24f2d4d013
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3
Akademický článek
Poly(I:C) Induces Distinct Liver Cell Type-Specific Responses in Hepatitis B Virus-Transgenic Mice In Vitro, but Fails to Induce These Signals In Vivo
Autor: Stefan Schefczyk, Xufeng Luo, Yaojie Liang, Martin Trippler, Mengji Lu, Heiner Wedemeyer, Hartmut H. Schmidt, Ruth Broering
Publikováno v: Viruses, Vol 15, Iss 5, p 1203 (2023)
Immunopathology in hepatitis B virus (HBV) infection is driven by innate and adaptive immunity. Whether the hepatitis B surface antigen (HBsAg) affects hepatic antiviral signalling was investigated in HBV-transgenic mouse models that either accumulat
Externí odkaz: https://doaj.org/article/27478dd03825464ca096fa6d7be86116
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4
Akademický článek
Antiviral Toll-like Receptor Signaling in Non-Parenchymal Liver Cells Is Restricted to TLR3
Autor: Melanie Werner, Stefan Schefczyk, Martin Trippler, Juergen W. Treckmann, Hideo A. Baba, Guido Gerken, Joerg F. Schlaak, Ruth Broering
Publikováno v: Viruses, Vol 14, Iss 2, p 218 (2022)
The role of non-parenchymal liver cells as part of the hepatic, innate immune system in the defense against hepatotropic viruses is not well understood. Here, primary human Kupffer cells, liver sinusoidal endothelial cells and hepatic stellate cells
Externí odkaz: https://doaj.org/article/075b8a1bdb704ceca5b88dd01c481c13
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