Zobrazeno 1 - 10
of 868
pro vyhledávání: '"Stefan Rose"'
Autor:
María Ángeles Rodríguez-Hernández, Mercedes Baena-Bustos, David Carneros, Carola Zurita-Palomo, Pablo Muñoz-Pinillos, Jaime Millán, Francisco Javier Padillo, Cristian Smerdou, Cayetano von Kobbe, Stefan Rose-John, Matilde Bustos
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105132- (2024)
Summary: Background: SARS-CoV-2 infection is considered as a relapsing inflammatory process with a dysregulation of IL-6 signalling. Classic IL-6 signalling is thought to represent a defence mechanism against pathogens. In contrast, IL-6 trans-signal
Externí odkaz:
https://doaj.org/article/cb1a454d27374e47aa940a4799b66b43
Autor:
Zaid W. El-Husseini, Dmitry Khalenkow, Andy Lan, Thys van der Molen, Chris Brightling, Alberto Papi, Klaus F. Rabe, Salman Siddiqui, Dave Singh, Monica Kraft, Bianca Beghe, Maarten van den Berge, Djoke van Gosliga, Martijn C. Nawijn, Stefan Rose-John, Gerard H. Koppelman, Reinoud Gosens
Publikováno v:
Respiratory Research, Vol 24, Iss 1, Pp 1-12 (2023)
Abstract Background Asthma is stratified into type 2-high and type 2-low inflammatory phenotypes. Limited success has been achieved in developing drugs that target type 2-low inflammation. Previous studies have linked IL-6 signaling to severe asthma.
Externí odkaz:
https://doaj.org/article/e4d93162eadc447d86daca4b0d26e0df
Autor:
Alessandro Castorina, Jurgen Scheller, Kevin A. Keay, Rubina Marzagalli, Stefan Rose-John, Iain L. Campbell
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 17, p 9453 (2024)
Inflammation with expression of interleukin 6 (IL-6) in the central nervous system (CNS) occurs in several neurodegenerative/neuroinflammatory conditions and may cause neurochemical changes to endogenous neuroprotective systems. Pituitary adenylate c
Externí odkaz:
https://doaj.org/article/c450db2ec6c84add80d0ba1d20309a1d
Autor:
Jan Pencik, Cecile Philippe, Michaela Schlederer, Emine Atas, Matteo Pecoraro, Sandra Grund-Gröschke, Wen (Jess) Li, Amanda Tracz, Isabel Heidegger, Sabine Lagger, Karolína Trachtová, Monika Oberhuber, Ellen Heitzer, Osman Aksoy, Heidi A. Neubauer, Bettina Wingelhofer, Anna Orlova, Nadine Witzeneder, Thomas Dillinger, Elisa Redl, Georg Greiner, David D’Andrea, Johnny R. Östman, Simone Tangermann, Ivana Hermanova, Georg Schäfer, Felix Sternberg, Elena E. Pohl, Christina Sternberg, Adam Varady, Jaqueline Horvath, Dagmar Stoiber, Tim I. Malcolm, Suzanne D. Turner, Eileen E. Parkes, Brigitte Hantusch, Gerda Egger, Stefan Rose-John, Valeria Poli, Suneil Jain, Chris W. D. Armstrong, Gregor Hoermann, Vincent Goffin, Fritz Aberger, Richard Moriggl, Arkaitz Carracedo, Cathal McKinney, Richard D. Kennedy, Helmut Klocker, Michael R. Speicher, Dean G. Tang, Ali A. Moazzami, David M. Heery, Marcus Hacker, Lukas Kenner
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-25 (2023)
Abstract Prostate cancer (PCa) is a common and fatal type of cancer in men. Metastatic PCa (mPCa) is a major factor contributing to its lethality, although the mechanisms remain poorly understood. PTEN is one of the most frequently deleted genes in m
Externí odkaz:
https://doaj.org/article/55713eefba5d493d89c7d396451b3eb7
Publikováno v:
Journal of Integrative Environmental Sciences, Vol 20, Iss 1 (2023)
Climate change – along with conflict, violence, and climate-related disasters – has the potential to accelerate many forms of human migration and mobility, and yet almost all of the key migration outcomes of interest (the decision to migrate, the
Externí odkaz:
https://doaj.org/article/d51c446e00584ceab493e9a94eab8e11
Autor:
Stephan A. Müller, Merav D. Shmueli, Xiao Feng, Johanna Tüshaus, Neele Schumacher, Ryan Clark, Brad E. Smith, An Chi, Stefan Rose-John, Matthew E. Kennedy, Stefan F. Lichtenthaler
Publikováno v:
Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-20 (2023)
Abstract Background The protease BACE1 is a major drug target for Alzheimer’s disease, but chronic BACE1 inhibition is associated with non-progressive cognitive worsening that may be caused by modulation of unknown physiological BACE1 substrates. M
Externí odkaz:
https://doaj.org/article/7fa094553b0842b2823d05e839ed3787
Autor:
Agatha Schwarz, Rebecca Philippsen, Serena G. Piticchio, Jan N. Hartmann, Robert Häsler, Stefan Rose-John, Thomas Schwarz
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
The organ-specific microbiome plays a crucial role in tissue homeostasis, among other things by inducing regulatory T cells (Treg). This applies also to the skin and in this setting short chain fatty acids (SCFA) are relevant. It was demonstrated tha
Externí odkaz:
https://doaj.org/article/70e017787ea1406f87cfbc7934e7f6e6
Autor:
Torben Mentrup, Anna Yamina Stumpff-Niggemann, Nadja Leinung, Christine Schlosser, Katja Schubert, Rebekka Wehner, Antje Tunger, Valentin Schatz, Patrick Neubert, Ann-Christine Gradtke, Janina Wolf, Stefan Rose-John, Paul Saftig, Alexander Dalpke, Jonathan Jantsch, Marc Schmitz, Regina Fluhrer, Ilse D. Jacobsen, Bernd Schröder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Dectin-1 is a critical component of the innate sensing repertoire which is involved in pattern based recognition of fungal pathogens. Here the authors show that intramembrane proteolysis is involved in the regulation of the antifungal host response b
Externí odkaz:
https://doaj.org/article/f2acefb3574e4b9da6fd801ea20dcfc5
Autor:
Marco Heestermans, Clément Naudin, Reiner K. Mailer, Sandra Konrath, Kristin Klaetschke, Anne Jämsä, Maike Frye, Carsten Deppermann, Giordano Pula, Piotr Kuta, Manuel A. Friese, Mathias Gelderblom, Albert Sickmann, Roger J. S. Preston, Jerzy-Roch Nofer, Stefan Rose-John, Lynn M. Butler, Ophira Salomon, Evi X. Stavrou, Thomas Renné
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Blood coagulation is started by contact to surfaces and this is the principle for a commonly used diagnostic clotting test, aPTT. Here, the authors identify the structure in coagulation factor XII that initiates surface-driven coagulation and use the
Externí odkaz:
https://doaj.org/article/23842f92b8124cd4863e0db2254038e6
Autor:
Mor Paldor, Orr Levkovitch‐Siany, Dana Eidelshtein, Revital Adar, Claes D Enk, Yitzhak Marmary, Sharona Elgavish, Yuval Nevo, Hadar Benyamini, Inbar Plaschkes, Shiri Klein, Alex Mali, Stefan Rose‐John, Amnon Peled, Eithan Galun, Jonathan H Axelrod
Publikováno v:
EMBO Molecular Medicine, Vol 14, Iss 8, Pp n/a-n/a (2022)
Abstract Irradiation‐induced alopecia and dermatitis (IRIAD) are two of the most visually recognized complications of radiotherapy, of which the molecular and cellular basis remains largely unclear. By combining scRNA‐seq analysis of whole skin
Externí odkaz:
https://doaj.org/article/5a050c8736134d50b74c2fbb8dbbdcf4