Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Stefan Rehnmark"'
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The aim of the study was to compare 3 blood sampling methods, including capillary blood sampling, for determining Tamoxifen (TAM), Z-endoxifen (END), and 4-hydroxytamoxifen (4HT) concentrations. High performance liquid chromatography-mass sp
Externí odkaz:
https://doaj.org/article/7a36e453c3cf43fcb54583805f341348
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 11, Pp 2209-2217 (1998)
Fatty liver dystrophy (fld) is an autosomal recessive mutation in mice characterized by hypertriglyceridemia and fatty liver during neonatal development. The fatty liver in fld/fld mice spontaneously resolves between the age of 14–18 days, at which
Externí odkaz:
https://doaj.org/article/f3ec8831734743a0893b46dc63c33d96
Autor:
Lisa-Mari Mörk, Stefan Rehnmark, Padideh Davoodpour, Giuseppe Danilo Norata, Lilian Larsson, Michael-Robin Witt, Johan Malm, Paolo Parini
Publikováno v:
PLoS ONE, Vol 8, Iss 12, p e78534 (2013)
BACKGROUND: Thyroid hormones (TH) regulate cholesterol metabolism but their use as lipid-lowering drugs is restricted due to negative cardiac effects. TH mimetic compounds modulating TH receptor β (THRβ) have been designed as potential drugs, reduc
Externí odkaz:
https://doaj.org/article/f4e0c781ac524f8d98d68581c14675a0
Autor:
Marita Högberg, Linda Rickardson, Marko J. Kallio, Emma Kutvonen, Stefan Rehnmark, Satu Orasniemi
Publikováno v:
Drug Design, Development and Therapy
Linda Rickardson,1 Emma Kutvonen,2 Satu Orasniemi,2 Marita Högberg,1 Marko J Kallio,2,3 Stefan Rehnmark1 1Noviga Research AB, Södertälje, Sweden; 2Department of Physiology, Institute of Biomedicine, University of Turku, 3Centre for Biotechnology,
Autor:
Lilian Larsson, Mats Gåfvels, Kristina Kannisto, Paolo Parini, Stefan Rehnmark, Gösta Eggertsen, Katharina Slätis, Paul Webb
Publikováno v:
Atherosclerosis. 237(2)
Thyroid hormone reduces plasma cholesterol and increases expression of low-density lipoprotein receptor (LDL-R) in liver, an effect mediated by thyroid receptor β (TRβ). The selective TRβ modulator GC-1 also enhances several steps in reverse chole
Autor:
Stefan Rehnmark, Nobuteru Usuda, Dorothee Feltkamp, Hebe M. Guardiola-Diaz, Stefan E.H. Alexson, Jan-Åke Gustafsson, Tatjana Albrektsen
Publikováno v:
Journal of Biological Chemistry. 274:23368-23377
Brown adipose tissue (BAT) hyperplasia is a fundamental physiological response to cold; it involves an acute phase of mitotic cell growth followed by a prolonged differentiation phase. Peroxisome proliferator-activated receptors (PPARs) are key regul
Autor:
Stefan Rehnmark, Johanna M. Lindquist
Publikováno v:
Journal of Biological Chemistry. 273:30147-30156
Brown adipose tissue hyperplasia is a fundamental response to low ambient temperature. We show here that cold exposure of an animal markedly increased the phosphorylation of mitogen-activated protein kinase (p42/p44) Erk1 and Erk2 in brown adipose ti
Publikováno v:
Journal of Lipid Research, Vol 39, Iss 11, Pp 2209-2217 (1998)
Fatty liver dystrophy (fld) is an autosomal recessive mutation in mice characterized by hypertriglyceridemia and fatty liver during neonatal development. The fatty liver in fld/fld mice spontaneously resolves between the age of 14–18 days, at which
Autor:
Anna Bäcksbro-Saeidi, Sandra Gordon, Peter Agback, Bo Carlsson, Konrad F. Koehler, Peter Brandt, Stefan Rehnmark, Theresa Apelqvist, Johan Malm, Mathias Färnegårdh, Gary J. Grover, William Nelson, Marlena Grynfarb
Publikováno v:
Journal of Medicinal Chemistry. 49:6635-6637
A new high-affinity thyroid hormone antagonist 6 with druglike properties was designed and synthesized. The compound behaved as an antagonist in a cell transactivation assay, and in a first in vivo experiment in rats.
Autor:
Stefan Rehnmark, Gerhard Heldmaier, Jan Nedergaard, Barbara Cannon, Martin Klingenspor, Anders Jacobsson, Pertti Kuusela
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 1345:327-337
To examine the regulation of lipoprotein lipase (LPL) gene expression, LPL mRNA levels in the brown adipose tissue of intact mice and in mouse brown adipocyte cultures were examined. In intact mice, exposure to cold resulted in a rapid, transient, 5-