Zobrazeno 1 - 10
of 107
pro vyhledávání: '"Stefan Rahlfs"'
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Crystallographic and biochemical characterization of Leishmania donovani Glucose 6-Phosphate Dehydrogenase (LdG6PD) containing the complete N-terminal domain reveal its role in LdG6PD tetramerization and substrate binding.
Externí odkaz:
https://doaj.org/article/fdd5343d42f34216b950a077bae05ada
Publikováno v:
Current Research in Structural Biology, Vol 4, Iss , Pp 87-95 (2022)
Plasmoredoxin is a 22 kDa thiol–disulfide oxidoreductase involved in cellular redox regulatory processes and antioxidant defense. The 1.6 Å structure of the protein, solved via X-ray crystallography, adopts a modified thioredoxin fold. The s
Externí odkaz:
https://doaj.org/article/4f8d7ba0d9d64a5fb094fe02f1f40fec
Autor:
Julie Harnischfeger, Mandy Beutler, Denise Salzig, Stefan Rahlfs, Katja Becker, Christoph G. Grevelding, Peter Czermak
Publikováno v:
Electronic Journal of Biotechnology, Vol 54, Iss , Pp 26-36 (2021)
Background: The heterologous expression of parasitic proteins is challenging because the sequence composition often differs significantly from host preferences. However, the production of such proteins is important because they are potential drug tar
Externí odkaz:
https://doaj.org/article/4fd2b672fc7b402d964cdd6bbfe5e85e
Autor:
Matthias Paulus Wagner, Pauline Formaglio, Olivier Gorgette, Jerzy Michal Dziekan, Christèle Huon, Isabell Berneburg, Stefan Rahlfs, Jean-Christophe Barale, Sheldon I. Feinstein, Aron B. Fisher, Didier Ménard, Zbynek Bozdech, Rogerio Amino, Lhousseine Touqui, Chetan E. Chitnis
Publikováno v:
Cell Reports, Vol 39, Iss 11, Pp 110923- (2022)
Summary: The uptake and digestion of host hemoglobin by malaria parasites during blood-stage growth leads to significant oxidative damage of membrane lipids. Repair of lipid peroxidation damage is crucial for parasite survival. Here, we demonstrate t
Externí odkaz:
https://doaj.org/article/19eda5da865f4a5c9cee9657e6e2cb8f
Autor:
Kristina Haeussler, Isabell Berneburg, Esther Jortzik, Julia Hahn, Mahsa Rahbari, Norma Schulz, Janina Preuss, Viktor A. Zapol’skii, Lars Bode, Anthony B. Pinkerton, Dieter E. Kaufmann, Stefan Rahlfs, Katja Becker
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-19 (2019)
Abstract Background Since malaria parasites highly depend on ribose 5-phosphate for DNA and RNA synthesis and on NADPH as a source of reducing equivalents, the pentose phosphate pathway (PPP) is considered an excellent anti-malarial drug target. In P
Externí odkaz:
https://doaj.org/article/cfe88e3100ec47a894b92d5d4f9bad02
Autor:
Reimar Krieg, Esther Jortzik, Alice-Anne Goetz, Stéphanie Blandin, Sergio Wittlin, Mourad Elhabiri, Mahsa Rahbari, Selbi Nuryyeva, Kerstin Voigt, Hans-Martin Dahse, Axel Brakhage, Svenja Beckmann, Thomas Quack, Christoph G. Grevelding, Anthony B. Pinkerton, Bruno Schönecker, Jeremy Burrows, Elisabeth Davioud-Charvet, Stefan Rahlfs, Katja Becker
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
Steroid units can facilitate membrane permeation and bioavailability in drugs. Here, using a medicinal chemistry program, Krieget al. identify an arylmethylamino steroid that kills Plasmodium parasites, likely through a chelate-based quinone methide
Externí odkaz:
https://doaj.org/article/00677fe185ed4193bb6f7cdfdfcd60a9
Autor:
Reimar Krieg, Esther Jortzik, Alice-Anne Goetz, Stéphanie Blandin, Sergio Wittlin, Mourad Elhabiri, Mahsa Rahbari, Selbi Nuryyeva, Kerstin Voigt, Hans-Martin Dahse, Axel Brakhage, Svenja Beckmann, Thomas Quack, Christoph G. Grevelding, Anthony B. Pinkerton, Bruno Schönecker, Jeremy Burrows, Elisabeth Davioud-Charvet, Stefan Rahlfs, Katja Becker
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-2 (2019)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/94072e21d7df445db92533cf466fed4f
Publikováno v:
PLoS ONE, Vol 12, Iss 4, p e0174837 (2017)
Hydrogen peroxide is an important antimicrobial agent but is also crucially involved in redox signaling and pathogen-host cell interactions. As a basis for systematically investigating intracellular H2O2 dynamics and regulation in living malaria para
Externí odkaz:
https://doaj.org/article/3e8a3e200be24ff19cce77e11c524990
Autor:
Thuvaraka Thavayogarajah, Preetish Gangopadhyay, Stefan Rahlfs, Katja Becker, Klaus Lingelbach, Jude M Przyborski, Anthony A Holder
Publikováno v:
PLoS ONE, Vol 10, Iss 4, p e0125191 (2015)
Plasmodium falciparum invades human red blood cells, residing in a parasitophorous vacuole (PV), with a parasitophorous vacuole membrane (PVM) separating the PV from the host cell cytoplasm. Here we have investigated the role of N-myristoylation and
Externí odkaz:
https://doaj.org/article/e5742749bdb24b33a8e9c913b2b38709
Publikováno v:
PLoS Pathogens, Vol 9, Iss 12, p e1003782 (2013)
In the malaria parasite Plasmodium falciparum, the cellular redox potential influences signaling events, antioxidant defense, and mechanisms of drug action and resistance. Until now, the real-time determination of the redox potential in malaria paras
Externí odkaz:
https://doaj.org/article/75739b0ed43c41f39996f29a26116d04