Zobrazeno 1 - 10
of 48
pro vyhledávání: '"Stefan R. Braam"'
Autor:
Dries Braeken, Guido R.Y. De Meyer, Ron M. A. Heeren, Matt Skinner, Sylvain Bernasconi, Yair Shemesh, Xi Yang, Elena Matsa, Helen Prior, Vincent F.M. Segers, Paz Yanez, Harm J. Knot, Michael Markert, Vitalina Gryshkova, Wim Martinet, Brian Guth, Krystle Correll, Damiano Lombardi, Jean-Pierre Valentin, Jeanette Woolard, Georgios Kosmidis, Annie Delaunois, Pieter-Jan Guns, Constantijn Franssen, Emeline M. Van Craenenbroeck, Alon Chen, Berta Cillero-Pastor, Miguel Angel Fernández, Thomas Pauwelyn, Gábor Kismihók, Paul G.A. Volders, Céline Grandmont, Stefan R. Braam
Publikováno v:
Journal of Pharmacological and Toxicological Methods, 105:106889. Elsevier Inc.
Journal of Pharmacological and Toxicological Methods
Journal of pharmacological and toxicological methods
Journal of Pharmacological and Toxicological Methods
Journal of pharmacological and toxicological methods
Safety pharmacology is an essential part of drug development aiming to identify, evaluate and investigate undesirable pharmacodynamic properties of a drug primarily prior to clinical trials. In particular, cardiovascular adverse drug reactions (ADR)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::593101cfca5ccfb1f18f522dbce41505
https://doi.org/10.1016/j.vascn.2020.106889
https://doi.org/10.1016/j.vascn.2020.106889
Autor:
Petra Mulder, Elena Dragicevic, Jean-Pierre Valentin, Maria L. H. Vlaming, Udo Kraushaar, Stefan R. Braam, Tessa de Korte, Richard Printemps
Publikováno v:
Journal of Pharmacological and Toxicological Methods
Safety pharmacology studies that evaluate drug candidates for potential cardiovascular liabilities remain a critical component of drug development. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have recently emerged as a new
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::380bd32619a2934c046999beae9ae085
https://doi.org/10.1016/j.vascn.2018.01.003
https://doi.org/10.1016/j.vascn.2018.01.003
Autor:
Antonio Zaza, Paul G.A. Volders, Roel L.H.M.G. Spätjens, Cristina Altrocchi, Tessa de Korte, Joyce Bernardi, Jordi Heijman, Stefan R. Braam
Publikováno v:
Europace
EP Europace, 22(9), 1431-1441. OXFORD UNIV PRESS
EP Europace, 22(9), 1431-1441. Oxford University Press
EP Europace, 22(9), 1431-1441. OXFORD UNIV PRESS
EP Europace, 22(9), 1431-1441. Oxford University Press
Aims Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) have proven valuable for studies in drug discovery and safety, although limitations regarding their structural and electrophysiological characteristics persist. In this study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abb04388a423edf9aa83b1d19f072598
https://pubmed.ncbi.nlm.nih.gov/32770183
https://pubmed.ncbi.nlm.nih.gov/32770183
Autor:
Joyce Bernardi, Jordi Heijman, Antonio Zaza, Tessa de Korte, Christina Altrocchi, Stefan R. Braam, Paul G.A. Volders, Roel R. L. Spätjens
Publikováno v:
Journal of Pharmacological and Toxicological Methods. 105:106723
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ee45f5ecca63e29e0003fe4db2c815e2
https://doi.org/10.1016/j.vascn.2020.106723
https://doi.org/10.1016/j.vascn.2020.106723
Autor:
Arie Reijerkerk, E. d'Amico, S. Dublin, J. Kamphorst, Stefan R. Braam, Karin Langenberg, C. Bonhomme
Publikováno v:
Cytotherapy. 22:S43
Background & Aim Cell and gene therapies show promise in providing new therapeutic strategies for a wide range of indications. Advancements in induced pluripotent stem cell (hiPSC) technologies have substantially expanded access to many human cell ty
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb02c7ce478cc46faffd95c85ef8646b
https://doi.org/10.1016/j.jcyt.2020.03.042
https://doi.org/10.1016/j.jcyt.2020.03.042
Publikováno v:
Biochemical and biophysical research communications, 497(4), 1135-1141. Academic Press
Biochemical and Biophysical Research Communications
Biochemical and Biophysical Research Communications
Multi electrode arrays (MEAs) are increasingly used to detect external field potentials in electrically active cells. Recently, in combination with cardiomyocytes derived from human (induced) pluripotent stem cells they have started to become a prefe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa864a0d21ca7ab825c62a2eaedc68d
https://hdl.handle.net/1887/78343
https://hdl.handle.net/1887/78343
Autor:
E. Boschman, Ronald Dekker, A. Waafi, Peter Nacken, Paul Dijkstra, Pasqualina M. Sarro, Nikolas Gaio, Maria L. H. Vlaming, C. Boucsein, Stefan R. Braam
Publikováno v:
2018 IEEE Micro Electro Mechanical Systems, MEMS 2018, 2018-January
This work presents the first multi-well plate that allows for simultaneous mechanical stimulation and electrical monitoring of multiple in-vitro cell cultures in parallel. Each well of the plate is equipped with an Organ-on-Chip (OOC) device consisti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d45e72cb0aae1ba0983e2f3ed3afd4a9
http://resolver.tudelft.nl/uuid:c6d11c61-0a13-42a3-8655-e9dba97f287a
http://resolver.tudelft.nl/uuid:c6d11c61-0a13-42a3-8655-e9dba97f287a
Autor:
Umber Saleem, Ljupcho Prodanov, Xiaoping Xu, Godfrey L. Smith, Marcelo C. Ribeiro, Robert Passier, Tessa de Korte, Diogo Mosqueira, Eric I. Rossman, Berend J. van Meer, Thomas Eschenhagen, Cathy Vickers, Stefan R. Braam, Leon G.J. Tertoolen, Christine L. Mummery, Chris Denning, Ingra Mannhardt, Victor Zamora Rodriguez, Maria Hortigon, Kate Harris, Karl S.A. Firth, Arne Hansen, Peter Clements, Marijn Vlaming, Vinoj George
Publikováno v:
Journal of Pharmacological and Toxicological Methods, 88(2):0227, 238-238. Elsevier
Journal of Pharmacological and Toxicological Methods, 88, 238-238
Journal of Pharmacological and Toxicological Methods, 88, 238-238
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a8af80e7a7196841a9bb68c299031d
https://research.utwente.nl/en/publications/inpulse-crackit-challenge-development-of-an-in-vitro-platform-using-physiologically-mature-human-induced-pluripotent-stem-cellderived-cardiomyocytes-to-screen-for-druginduced-effects-on-cardiac-contractility(2637840e-a1e7-4c9a-9261-668410be9aeb).html
https://research.utwente.nl/en/publications/inpulse-crackit-challenge-development-of-an-in-vitro-platform-using-physiologically-mature-human-induced-pluripotent-stem-cellderived-cardiomyocytes-to-screen-for-druginduced-effects-on-cardiac-contractility(2637840e-a1e7-4c9a-9261-668410be9aeb).html
Autor:
Douwe E. Atsma, Henk P. J. Buermans, Georgios Kosmidis, Andras Dinnyes, Richard P. Davis, Karin Langenberg, Christine L. Mummery, Simona Casini, David A. Elliott, Eszter Varga, Stefan R. Braam, Cheryl Dambrot
Publikováno v:
Experimental Cell Research, 327(2), 297-306
Recent methodological advances have improved the ease and efficiency of generating human induced pluripotent stem cells (hiPSCs), but this now typically results in a greater number of hiPSC clones being derived than can be wholly characterized. It is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e87a93472fad3a9245314b054217f5a2
https://doi.org/10.1016/j.yexcr.2014.05.001
https://doi.org/10.1016/j.yexcr.2014.05.001
Autor:
Douwe E. Atsma, Christine L. Mummery, Matthew J. Birket, Leon G.J. Tertoolen, Stefan R. Braam, Cheryl Dambrot
Publikováno v:
Journal of Cellular and Molecular Medicine
It has been known for over 20 years that foetal calf serum can induce hypertrophy in cultured cardiomyocytes but this is rarely considered when examining cardiomyocytes derived from pluripotent stem cells (PSC). Here, we determined how serum affected
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::049e8e5ac09b623f1388c61d57ce5cc3
https://doi.org/10.1111/jcmm.12356
https://doi.org/10.1111/jcmm.12356