Decreased GPIHBP1 protein levels in visceral adipose tissue partly underlie the hypertriglyceridemic phenotype in insulin resistance.

Autor: R Preethi Surendran, Shanti D Udayyapan, Mercedes Clemente-Postigo, Stefan R Havik, Alinda W M Schimmel, Fransisco Tinahones, Max Nieuwdorp, Geesje M Dallinga-Thie

Publikováno v: PLoS ONE, Vol 13, Iss 11, p e0205858 (2018)

GPIHBP1 is a protein localized at the endothelial cell surface that facilitates triglyceride (TG) lipolysis by binding lipoprotein lipase (LPL). Whether Glycosyl Phosphatidyl Inositol high density lipoprotein binding protein 1 (GPIHBP1) function is i

Externí odkaz: https://doaj.org/article/cc63b146c6084a3396df03125c01ce75

Impact of the B Cell Growth Factor APRIL on the Qualitative and Immunological Characteristics of Atherosclerotic Plaques.

Autor: Sophie J Bernelot Moens, Sander I van Leuven, Kang H Zheng, Stefan R Havik, Miranda V Versloot, Leonie M van Duivenvoorde, Michael Hahne, Erik S G Stroes, Dominique L Baeten, Anouk A J Hamers

Publikováno v: PLoS ONE, Vol 11, Iss 11, p e0164690 (2016)

Studies on the role of B lymphocytes in atherosclerosis development, have yielded contradictory results. Whereas B lymphocyte-deficiency aggravates atherosclerosis in mice; depletion of mature B lymphocytes reduces atherosclerosis. These observations

Externí odkaz: https://doaj.org/article/aecda9109433457aa32c14b91ba0f0e9

Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome

Autor: Annick V. Hartstra, Valentina Schüppel, Sultan Imangaliyev, Anouk Schrantee, Andrei Prodan, Didier Collard, Evgeni Levin, Geesje Dallinga-Thie, Mariette T. Ackermans, Maaike Winkelmeijer, Stefan R. Havik, Amira Metwaly, Ilias Lagkouvardos, Anika Nier, Ina Bergheim, Mathias Heikenwalder, Andreas Dunkel, Aart J. Nederveen, Gerhard Liebisch, Giulia Mancano, Sandrine P. Claus, Alfonso Benítez-Páez, Susanne E. la Fleur, Jacques J. Bergman, Victor Gerdes, Yolanda Sanz, Jan Booij, Elles Kemper, Albert K. Groen, Mireille J. Serlie, Dirk Haller, Max Nieuwdorp

Publikováno v: Molecular Metabolism, Vol 42, Iss , Pp 101076- (2020)

Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the

Externí odkaz: https://doaj.org/article/f56c72eb8af747ea93ef6da1e44aac7d

Gut-derived bacterial flagellin induces beta-cell inflammation and dysfunction

Autor: Abraham S. Meijnikman, Maaike Winkelmeijer, C. Bruce Verchere, Martin Stahl, Mark Davids, Olivier R. Busch, Hongbing Yu, Galina Soukhatcheva, Willem M. de Vos, Hilde Herrema, Bert-Jan H. van den Born, Max Nieuwdorp, Maurits de Brauw, Marc G. Besselink, Derek L. Dai, Manon Balvers, Stefan R. Havik, Caixia Ma, Ömrüm Aydin, Clara Belzer, Bruce A. Vallance, Torsten P. M. Scheithauer, Guido J. Bakker, Daniël H. van Raalte, Arnold W. J. M. van de Laar

ObjectiveHyperglycemia and type 2 diabetes (T2D) are caused by failure of pancreatic beta cells. The role of the gut microbiota in T2D has been studied but causal links remain enigmatic.DesignObese individuals with or without T2D were included from t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::32d97da00ab7dfb5f1b4720a0262f50f
https://doi.org/10.1101/2021.10.07.463317

Infusion of donor feces affects the gut–brain axis in humans with metabolic syndrome

Autor: Albert K. Groen, Alfonso Benítez-Páez, Ilias Lagkouvardos, Dirk Haller, Anika Nier, Amira Metwaly, Sultan Imangaliyev, Aart J. Nederveen, Susanne E. la Fleur, Maaike Winkelmeijer, Annick V. Hartstra, Gerhard Liebisch, Andreas Dunkel, Yolanda Sanz, Andrei Prodan, Jacques J. Bergman, Evgeni Levin, Jan Booij, Anouk Schrantee, Valentina Schüppel, Didier Collard, Max Nieuwdorp, Ina Bergheim, Victor E. A. Gerdes, Mathias Heikenwalder, E. M. Kemper, Stefan R. Havik, Mireille J. Serlie, Sandrine P. Claus, Giulia Mancano, Geesje M. Dallinga-Thie, Mariëtte T. Ackermans

Publikováno v: Digital.CSIC. Repositorio Institucional del CSIC
instname
Molecular Metabolism, Vol 42, Iss, Pp 101076-(2020)
Molecular Metabolism
Digital.CSIC: Repositorio Institucional del CSIC
Consejo Superior de Investigaciones Científicas (CSIC)
Molecular metabolism, 42:101076. Elsevier GmbH

Objective: Increasing evidence indicates that intestinal microbiota play a role in diverse metabolic processes via intestinal butyrate production. Human bariatric surgery data suggest that the gut-brain axis is also involved in this process, but the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::515f925be4f5159de27cd3a23a2969ef
http://hdl.handle.net/10261/246782