Výsledky vyhledávání - "Stefan Rännar"

Akademický článek

Metabolic profiling of zebrafish embryo development from blastula period to early larval stages.

Autor: Sundeep S Dhillon, Frida Torell, Magdalena Donten, Katrin Lundstedt-Enkel, Kate Bennett, Stefan Rännar, Johan Trygg, Torbjörn Lundstedt

Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0213661 (2019)

The zebrafish embryo is a popular model for drug screening, disease modelling and molecular genetics. In this study, samples were obtained from zebrafish at different developmental stages. The stages that were chosen were 3/4, 4/5, 24, 48, 72 and 96

Externí odkaz: https://doaj.org/article/ce4b6ac8477c416faaec624d121b3eaa

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Akademický článek

Metabolic Profiling of Systemic Lupus Erythematosus and Comparison with Primary Sjögren's Syndrome and Systemic Sclerosis.

Autor: Anders A Bengtsson, Johan Trygg, Dirk M Wuttge, Gunnar Sturfelt, Elke Theander, Magdalena Donten, Thomas Moritz, Carl-Johan Sennbro, Frida Torell, Christian Lood, Izabella Surowiec, Stefan Rännar, Torbjörn Lundstedt

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0159384 (2016)

Systemic lupus erythematosus (SLE) is a chronic inflammatory autoimmune disease which can affect most organ systems including skin, joints and the kidney. Clinically, SLE is a heterogeneous disease and shares features of several other rheumatic disea

Externí odkaz: https://doaj.org/article/ccf4f54f3b3845f7adb5842f0ce73efa

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Akademický článek

Multi-Organ Contribution to the Metabolic Plasma Profile Using Hierarchical Modelling.

Autor: Frida Torell, Kate Bennett, Silvia Cereghini, Stefan Rännar, Katrin Lundstedt-Enkel, Thomas Moritz, Cecile Haumaitre, Johan Trygg, Torbjörn Lundstedt

Publikováno v: PLoS ONE, Vol 10, Iss 6, p e0129260 (2015)

Hierarchical modelling was applied in order to identify the organs that contribute to the levels of metabolites in plasma. Plasma and organ samples from gut, kidney, liver, muscle and pancreas were obtained from mice. The samples were analysed using

Externí odkaz: https://doaj.org/article/c82fed5c246343d7be0c2f60c7f58a5c

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Metabolic profiling of zebrafish embryo development from blastula period to early larval stages

Autor: Stefan Rännar, Sundeep Singh Dhillon, Katrin Lundstedt-Enkel, Magdalena Donten, Torbjörn Lundstedt, Kate Bennett, Johan Trygg, Frida Torell

Publikováno v: PLOS ONE, 14 (5), Art. Nr.: e0213661
PLoS ONE
PLoS ONE, Vol 14, Iss 5, p e0213661 (2019)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26931856167e66e1382666852c90c846
https://publikationen.bibliothek.kit.edu/1000099908

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Metabolic Profiling of Multiorgan Samples : Evaluation of MODY5/RCAD Mutant Mice

Autor: Silvia Cereghini, Torbjörn Lundstedt, Kate Bennett, Katrin Lundstedt-Enkel, Johan Trygg, Thomas Moritz, Melanie Fabre, Frida Torell, Cécile Haumaitre, Stefan Rännar

In the present study, we performed a metabolomics analysis to evaluate a MODY5/RCAD mouse mutant line as a potential model for HNF1B-associated diseases. Gas chromatography time-of-flight mass spectrometry (GC-TOF-MS) of gut, kidney, liver, muscle, p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04f6549782ecf4394bed83ad60473f25
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-361549

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The effects of thawing on the plasma metabolome : evaluating differences between thawed plasma and multi-organ samples

Autor: Kate Bennett, Katrin Lundstedt-Enkel, Frida Torell, Johan Trygg, Stefan Rännar, Torbjörn Lundstedt

Publikováno v: Metabolomics
Metabolomics, 13 (6), Art. Nr.: 66

Introduction Post-collection handling, storage and transportation can affect the quality of blood samples. Pre-analytical biases can easily be introduced and can jeopardize accurate profiling of the plasma metabolome. Consequently, a mouse study must

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5daee64fe91cfd9e451b7558e06bcd1b
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-135201

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Tissue sample stability: thawing effect on multi-organ samples

Autor: Katrin Lundstedt-Enkel, Kate Bennett, Cécile Haumaitre, Silvia Cereghini, Stefan Rännar, Torbjörn Lundstedt, Thomas Moritz, Frida Torell, Johan Trygg

Publikováno v: Metabolomics
Metabolomics, 2016, 12 (2), pp.19. ⟨10.1007/s11306-015-0933-1⟩
Metabolomics, Springer Verlag, 2016, 12 (2), pp.19. ⟨10.1007/s11306-015-0933-1⟩

International audience; Correct handling of samples is essential in metabolomic studies. Improper handling and prolonged storage of samples has unwanted effects on the metabolite levels. The aim of this study was to identify the effects that thawing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df7a5eb5b59a1a7dbf4fafc521174b84
https://hal.science/hal-01538349

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Strategy for Optimizing LC-MS Data Processing in Metabolomics: A Design of Experiments Approach

Autor: John P. Shockcor, Mattias Eliasson, Stefan Rännar, Erik Johansson, Emma Marsden-Edwards, Thomas Moritz, Rasmus Bødker Madsen, Johan Trygg, Magdalena Donten

Publikováno v: Analytical Chemistry. 84:6869-6876

A strategy for optimizing LC-MS metabolomics data processing is proposed. We applied this strategy on the XCMS open source package written in R on both human and plant biology data. The strategy is a sequential design of experiments (DoE) based on a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f0adf3fd57aeb6847a943082aa5e1c0
https://doi.org/10.1021/ac301482k

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A Multivariate Chemical Similarity Approach to Search for Drugs of Potential Environmental Concern

Autor: Patrik L. Andersson, Stefan Rännar, Jerker Fick

Publikováno v: Journal of Chemical Information and Modeling. 51:1788-1794

A structural similarity tool was developed and aimed to search for environmentally persistent drugs. The basis for the tool was a selection of so-called anchor molecules and a multidimensional chemical map of drugs. The map was constructed using prin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b2222703b2555f8c6bcc056b7323397
https://doi.org/10.1021/ci200107b

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From Data Processing to Multivariate Validation - Essential Steps in Extracting Interpretable Information from Metabolomics Data

Autor: Mattias Eliasson, Stefan Rännar, Johan Trygg

Publikováno v: Current Pharmaceutical Biotechnology. 12:996-1004

In metabolomics studies there is a clear increase of data. This indicates the necessity of both having a battery of suitable analysis methods and validation procedures able to handle large amounts of data. In this review, an overview of the metabolom

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f9de9a9e9a12a2c3000c19094c47562
https://doi.org/10.2174/138920111795909041

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