Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Stefan Prekovic"'
Autor:
Isabel Mayayo‐Peralta, Donna O. Debets, Stefan Prekovic, Karianne Schuurman, Suzanne Beerthuijzen, Mathilde Almekinders, Joyce Sanders, Cathy B. Moelans, Sandra Saleiro, Jelle Wesseling, Paul J. vanDiest, Rui Henrique, Carmen Jerónimo, Maarten Altelaar, Wilbert Zwart
Publikováno v:
Molecular Oncology, Vol 18, Iss 1, Pp 156-169 (2024)
Breast cancer (BCa) is a highly heterogeneous disease, with hormone receptor status being a key factor in patient prognostication and treatment decision‐making. The majority of primary tumours are positive for oestrogen receptor alpha (ERα), which
Externí odkaz:
https://doaj.org/article/729f177a629a4bda894d9576a75e0d22
Autor:
Stefan Prekovic, Theofilos Chalkiadakis, Merel Roest, Daniel Roden, Catrin Lutz, Karianne Schuurman, Mark Opdam, Liesbeth Hoekman, Nina Abbott, Tanja Tesselaar, Maliha Wajahat, Amy R Dwyer, Isabel Mayayo‐Peralta, Gabriela Gomez, Maarten Altelaar, Roderick Beijersbergen, Balázs Győrffy, Leonie Young, Sabine Linn, Jos Jonkers, Wayne Tilley, Theresa Hickey, Damir Vareslija, Alexander Swarbrick, Wilbert Zwart
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 12, Pp n/a-n/a (2023)
Abstract Glucocorticoid receptor (GR) is a transcription factor that plays a crucial role in cancer biology. In this study, we utilized an in silico‐designed GR activity signature to demonstrate that GR relates to the proliferative capacity of nume
Externí odkaz:
https://doaj.org/article/7f89e9b972df425581429cdb0b5d1a09
Publikováno v:
Endocrines, Vol 4, Iss 2, Pp 269-280 (2023)
Sex hormones and their receptors play a crucial role in human sexual dimorphism and have been traditionally associated with hormone-dependent cancers like breast, prostate, and endometrial cancer. However, recent research has broadened our understand
Externí odkaz:
https://doaj.org/article/df57188c4c7d4048b75123127abdc8bd
Autor:
Anna G. Manjón, Stefano Giustino Manzo, Stefan Prekovic, Leon Potgeter, Tom van Schaik, Ning Qing Liu, Koen Flach, Daniel Peric-Hupkes, Stacey Joosten, Hans Teunissen, Anoek Friskes, Mila Ilic, Dorine Hintzen, Vinícius H. Franceschini-Santos, Wilbert Zwart, Elzo de Wit, Bas van Steensel, René H. Medema
Publikováno v:
Cell Reports, Vol 42, Iss 10, Pp 113124- (2023)
Summary: Acquired drug resistance is a major problem in the treatment of cancer. hTERT-immortalized, untransformed RPE-1 cells can acquire resistance to Taxol by derepressing the ABCB1 gene, encoding for the multidrug transporter P-gP. Here, we inves
Externí odkaz:
https://doaj.org/article/7a246652a6144b62a928cb9cb12c35f2
Autor:
Joana Silva, Ferhat Alkan, Sofia Ramalho, Goda Snieckute, Stefan Prekovic, Ana Krotenberg Garcia, Santiago Hernández-Pérez, Rob van der Kammen, Danielle Barnum, Liesbeth Hoekman, Maarten Altelaar, Wilbert Zwart, Saskia Jacoba Elisabeth Suijkerbuijk, Simon Bekker-Jensen, William James Faller
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Intestinal stem cells are responsible for replenishing cells within the high-turnover intestinal epithelium. Here they show that ribosome dynamics affect intestinal stem cell identity through a mechanism that is triggered by changes in nutrient avail
Externí odkaz:
https://doaj.org/article/e5d3a0beb6bb494d83b16a5ab563b7a2
Autor:
Stefan Prekovic, Karianne Schuurman, Isabel Mayayo-Peralta, Anna G. Manjón, Mark Buijs, Selçuk Yavuz, Max D. Wellenstein, Alejandro Barrera, Kim Monkhorst, Anne Huber, Ben Morris, Cor Lieftink, Theofilos Chalkiadakis, Ferhat Alkan, Joana Silva, Balázs Győrffy, Liesbeth Hoekman, Bram van den Broek, Hans Teunissen, Donna O. Debets, Tesa Severson, Jos Jonkers, Timothy Reddy, Karin E. de Visser, William Faller, Roderick Beijersbergen, Maarten Altelaar, Elzo de Wit, Rene Medema, Wilbert Zwart
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
Glucocorticoids (GC) are reported to block cancer cell proliferation, but the mode of action is unclear. Here the authors show that glucocorticoid receptor activation induces cancer cell dormancy in lung cancer by regulating CDKN1C expression through
Externí odkaz:
https://doaj.org/article/e4c712e9c2534821b3dbea828efb9470
Autor:
Floriane Racine, Christophe Louandre, Corinne Godin, Baptiste Chatelain, Stefan Prekovic, Wilbert Zwart, Antoine Galmiche, Zuzana Saidak
Publikováno v:
Cancers, Vol 15, Iss 5, p 1531 (2023)
Background: The coagulome, defined as the repertoire of genes that locally regulate coagulation and fibrinolysis, is a key determinant of vascular thromboembolic complications of cancer. In addition to vascular complications, the coagulome may also r
Externí odkaz:
https://doaj.org/article/764bc56a793e4e2b98a8d07a85de96fe
Autor:
Isabel Mayayo-Peralta, Beatrice Faggion, Liesbeth Hoekman, Ben Morris, Cor Lieftink, Isabella Goldsbrough, Lakjaya Buluwela, Joseph C. Siefert, Harm Post, Maarten Altelaar, Roderick Beijersbergen, Simak Ali, Wilbert Zwart, Stefan Prekovic
Publikováno v:
Cancers, Vol 13, Iss 24, p 6314 (2021)
While endocrine therapy is highly effective for the treatment of oestrogen receptor-α (ERα)-positive breast cancer, a significant number of patients will eventually experience disease progression and develop treatment-resistant, metastatic cancer.
Externí odkaz:
https://doaj.org/article/58b90f13e7fb49dd93c8af3b913707cd
Autor:
Sander AL Palit, Daniel Vis, Suzan Stelloo, Cor Lieftink, Stefan Prekovic, Elise Bekers, Ingrid Hofland, Tonći Šuštić, Liesanne Wolters, Roderick Beijersbergen, Andries M Bergman, Balázs Győrffy, Lodewyk FA Wessels, Wilbert Zwart, Michiel S van der Heijden
Publikováno v:
eLife, Vol 8 (2019)
Androgen receptor (AR) inhibitors represent the mainstay of prostate cancer treatment. In a genome-wide CRISPR-Cas9 screen using LNCaP prostate cancer cells, loss of co-repressor TLE3 conferred resistance to AR antagonists apalutamide and enzalutamid
Externí odkaz:
https://doaj.org/article/caac5d360d0a4963af4d216fca34abf4
Autor:
Marta Nadal, Stefan Prekovic, Nerea Gallastegui, Christine Helsen, Montserrat Abella, Karolina Zielinska, Marina Gay, Marta Vilaseca, Marta Taulès, Adriaan B. Houtsmuller, Martin E. van Royen, Frank Claessens, Pablo Fuentes-Prior, Eva Estébanez-Perpiñá
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
The androgen receptor is crucial for the development and physiology of reproductive organs. Here the authors present the structure of the androgen receptor ligand-binding domain bound to dihydrotestosterone, identifying a homodimerization interface t
Externí odkaz:
https://doaj.org/article/e16dab5dd1bd4ba28ae91fea89b288b4