Paracrine Interleukin 6 Induces Cerebral Remodeling at Early Stages After Unilateral Common Carotid Artery Occlusion in Mice

Autor: Melanie T. C. Kuffner, Stefan P. Koch, Marieluise Kirchner, Susanne Mueller, Janet Lips, Jeehye An, Philipp Mertins, Ulrich Dirnagl, Matthias Endres, Philipp Boehm-Sturm, Christoph Harms, Christian J. Hoffmann

Publikováno v: Frontiers in Cardiovascular Medicine, Vol 8 (2022)

AimsCarotid artery disease is frequent and can result in chronic modest hypoperfusion of the brain. If no transient ischemic attack or stroke occur, it is classified asymptomatic. In the long-term, though, it can lead to cognitive impairment. Fosteri

Externí odkaz: https://doaj.org/article/2c0c2952aeb14ee5809eafc2724c1a93

In vivo characterization of brain tumor biomechanics: magnetic resonance elastography in intracranial B16 melanoma and GL261 glioma mouse models

Autor: Anastasia Janas, Jakob Jordan, Gergely Bertalan, Tom Meyer, Jan Bukatz, Ingolf Sack, Carolin Senger, Melina Nieminen-Kelhä, Susan Brandenburg, Irina Kremenskaia, Kiril Krantchev, Sanaria Al-Rubaiey, Susanne Mueller, Stefan Paul Koch, Philipp Boehm-Sturm, Rolf Reiter, Daniel Zips, Peter Vajkoczy, Gueliz Acker

Publikováno v: Frontiers in Oncology, Vol 14 (2024)

IntroductionMagnetic Resonance Elastography (MRE) allows the non-invasive quantification of tumor biomechanical properties in vivo. With increasing incidence of brain metastases, there is a notable absence of appropriate preclinical models to investi

Externí odkaz: https://doaj.org/article/d4db16f3f3f64148851cbf1822a2cad3

Apolipoprotein-E deficiency leads to brain network alteration characterized by diffusion MRI and graph theory

Autor: Margaret Caroline Stapleton, Stefan Paul Koch, Devin Raine Everaldo Cortes, Samuel Wyman, Kristina E. Schwab, Susanne Mueller, Christopher Gordon McKennan, Philipp Boehm-Sturm, Yijen Lin Wu

Publikováno v: Frontiers in Neuroscience, Vol 17 (2023)

Late-onset Alzheimer’s disease (LOAD) is a major health concern for senior citizens, characterized by memory loss, confusion, and impaired cognitive abilities. Apolipoprotein-E (ApoE) is a well-known risk factor for LOAD, though exactly how ApoE af

Externí odkaz: https://doaj.org/article/3449a712c14044958258e61c0ef0d4c6

Increased flexibility of brain dynamics in patients with multiple sclerosis

Autor: Nina von Schwanenflug, Stefan P Koch, Stephan Krohn, Tommy A A Broeders, David M Lydon-Staley, Dani S Bassett, Menno M Schoonheim, Friedemann Paul, Carsten Finke

Publikováno v: von Schwanenflug, N, Koch, S P, Krohn, S, Broeders, T A A, Lydon-Staley, D M, Bassett, D S, Schoonheim, M M, Paul, F & Finke, C 2023, ' Increased flexibility of brain dynamics in patients with multiple sclerosis ', Brain Communications, vol. 5, no. 3, fcad143 . https://doi.org/10.1093/braincomms/fcad143
Brain Communications, 5(3):fcad143. Oxford University Press

Patients with multiple sclerosis consistently show widespread changes in functional connectivity. Yet, alterations are heterogeneous across studies, underscoring the complexity of functional reorganization in multiple sclerosis. Here, we aim to provi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c821b15fafcad3ab7b3e10e4ddcdb65
https://research.vumc.nl/en/publications/b0fff487-f471-40c5-863d-6ef8922fba08

Devaluation and sequential decisions: linking goal-directed and model-based behaviour

Autor: Eva eFriedel, Stefan P Koch, Jean eWendt, Andreas eHeinz, Lorenz eDeserno, Florian eSchlagenhauf

Publikováno v: Frontiers in Human Neuroscience, Vol 8 (2014)

In experimental psychology different experiments have been developed to assess goal–directed as compared to habitual control over instrumental decisions. Similar to animal studies selective devaluation procedures have been used. More recently seque

Externí odkaz: https://doaj.org/article/aa75b22e4dcc470ba30f6af40260599f