Eight weeks of treatment with mineralocorticoid receptor blockade does not alter vascular function in individuals with and without type 2 diabetes

Autor: Stine H. Finsen, Mie R. Hansen, Pernille B. L. Hansen, Stefan P. Mortensen

Publikováno v: Physiological Reports, Vol 12, Iss 7, Pp n/a-n/a (2024)

Abstract Aldosterone has been suggested to be involved in the microvascular complications observed in type 2 diabetes. We aimed to investigate the effect of mineralocorticoid receptor (MR) blockade on endothelial function in individuals with type 2 d

Externí odkaz: https://doaj.org/article/2f8529b21233424398bcd4e0eefe0ef8

Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes

Autor: Stine H. Finsen, Mie R. Hansen, Joachim Hoffmann‐Petersen, Henrik F. Højgaard, Stefan P. Mortensen

Publikováno v: Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)

Abstract Individuals with type 2 diabetes have an increased risk of cardiovascular disease. A correlation between plasma aldosterone and hyperinsulinemia has been demonstrated in vivo, and hyperinsulinemia and insulin resistance are independently ass

Externí odkaz: https://doaj.org/article/98e1cfc485624d6a992603dc85df287b

Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes

Autor: Joachim Hoffmann-Petersen, Henrik F. Højgaard, Mie R. Hansen, Stine Louise Høyer Finsen, Stefan P. Mortensen

Publikováno v: Finsen, S L H, Hansen, M R, Hoffmann-Petersen, J, Højgaard, H F & Mortensen, S P 2021, ' Eight weeks of mineralocorticoid blockade does not improve insulin sensitivity in type 2 diabetes ', Physiological Reports, vol. 9, no. 15, e14971 . https://doi.org/10.14814/phy2.14971
Physiological Reports
Physiological Reports, Vol 9, Iss 15, Pp n/a-n/a (2021)

Individuals with type 2 diabetes have an increased risk of cardiovascular disease. A correlation between plasma aldosterone and hyperinsulinemia has been demonstrated in vivo, and hyperinsulinemia and insulin resistance are independently associated w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d6307e456af2493a7208dd3ac8b1a93
https://findresearcher.sdu.dk:8443/ws/files/190554099/phy2.14971.pdf

Cardiorespiratory responses to high-intensity skeletal muscle metaboreflex activation in chronic obstructive pulmonary disease

Autor: Stefan P. Mortensen, Ulrik Winning Iepsen, Paul J. Fadel, Niels H. Secher, Thales C. Barbosa, Peter Lange, Camilla Koch Ryrsø, Bente Klarlund Pedersen, Mette Rugbjerg, Pia Thaning

Publikováno v: Iepsen, U W, Ryrsø, C K, Rugbjerg, M, Secher, N H, Barbosa, T C, Lange, P, Thaning, P, Pedersen, B K, Mortensen, S P & Fadel, P J 2021, ' Cardiorespiratory responses to high-intensity skeletal muscle metaboreflex activation in chronic obstructive pulmonary disease ', Clinical Physiology and Functional Imaging, vol. 41, no. 2, pp. 146-155 . https://doi.org/10.1111/cpf.12678
Iepsen, U W, Ryrsø, C K, Rugbjerg, M, Secher, N H, Barbosa, T C, Lange, P, Thaning, P, Pedersen, B K, Mortensen, S P & Fadel, P J 2021, ' Cardiorespiratory responses to high intensity skeletal muscle metaboreflex activation in chronic obstructive pulmonary disease ', Clinical Physiology and Functional Imaging, vol. 41, no. 2, pp. 146-155 . https://doi.org/10.1111/cpf.12678

Background: Augmented skeletal muscle metaboreflex activation may accompany chronic obstructive pulmonary disease (COPD). The maintained metaboreflex control of mean arterial pressure (MAP) that has been reported may reflect limited evaluation using

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::573a446332f4cd8916e2eb0d8c79baa8
https://curis.ku.dk/portal/da/publications/cardiorespiratory-responses-to-highintensity-skeletal-muscle-metaboreflex-activation-in-chronic-obstructive-pulmonary-disease(7d85c97f-3208-4a46-9421-91e107c9e47b).html

Leg blood flow is impaired during small muscle mass exercise in patients with COPD

Autor: Peter Lange, Bente Klarlund Pedersen, Gregers Druedal Wibe Munch, Camilla Koch Ryrsø, Mette Rugbjerg, Ulrik Winning Iepsen, Pia Thaning, Stefan P. Mortensen, Ylva Hellsten, Niels H. Secher

Publikováno v: Iepsen, U W, Munch, G D W, Rugbjerg, M, Ryrsø, C K, Secher, N H, Hellsten, Y, Lange, P, Pedersen, B K, Thaning, P & Mortensen, S P 2017, ' Leg blood flow is impaired during small muscle mass exercise in patients with COPD ', Journal of Applied Physiology, vol. 123, no. 3, pp. 624-631 . https://doi.org/10.1152/japplphysiol.00178.2017

Skeletal muscle blood flow is regulated to match the oxygen demand and dysregulation could contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). We measured leg hemodynamics and metabolites from vasoactive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2a0b4086ccdcd7920d39602fd5dc98
https://doi.org/10.1152/japplphysiol.00178.2017