Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Stefan Ohla"'
Autor:
Ales Charvat, Raphael D. Urban, Benjamin Krafft, Konstantin Wink, Bernd Abel, Tillmann G. Fischer, Kirsten Zeitler, Stefan Ohla, Detlev Belder
Publikováno v:
Analytical and Bioanalytical Chemistry
Graphical abstract By the on-chip integration of a droplet generator in front of an emitter tip, droplets of non-polar solvents are generated in a free jet of an aqueous matrix. When an IR laser irradiates this free liquid jet consisting of water as
Publikováno v:
Analytical and Bioanalytical Chemistry. 410:5741-5750
In this article, we present a novel approach for the sheathless coupling of microchip electrophoresis (MCE) with electrospray mass spectrometry (ESI-MS). The key element is an ion-conductive hydrogel membrane, placed between the separation channel an
Publikováno v:
Lab on a Chip. 17:1996-2002
A droplet-based microfluidic device with seamless hyphenation to electrospray mass spectrometry was developed to rapidly investigate organic reactions in segmented flow providing a versatile tool for drug development. A chip-MS interface with an inte
Publikováno v:
Analytical and Bioanalytical Chemistry. 407:387-396
A strength of microfluidic chip laboratories is the rapid heat transfer that, in principle, enables a very homogeneous temperature distribution in chemical processes. In order to exploit this potential, we present an integrated chip system where the
Publikováno v:
ELECTROPHORESIS. 36:449-456
Herein, we present a straightforward surface modification technique for PDMS-based microfluidic devices. The method takes advantage of the high reactivity of concentrated sulfuric acid to enhance the surface properties of PDMS bulk material. This res
Publikováno v:
ELECTROPHORESIS. 35:1880-1886
A comprehensive study for a sensitivity optimization in MCE with mass spectrometric detection is presented. As a text mixture, we chose a mixture of the cardiac drugs propranolol, bisoprolol, lidocaine, procaine and studied the effect of different ch
Autor:
Carsten Lotter, Stefan Ohla, Detlev Belder, Rico Warias, Laura Mauritz, Patrick J. W. Fuchs, Josef J. Heiland, Kirsten Zeitler
Publikováno v:
Lab on a chip. 17(1)
We present a microfluidic system, seamlessly integrating microflow and microbatch synthesis with a HPLC/nano-ESI-MS functionality on a single glass chip. The microfluidic approach allows to efficiently steer and dispense sample streams down to the na
Publikováno v:
Analyst
Chip-based microfluidics enable the seamless integration of different functions into single devices. Here, we present microfluidic chips containing porous polymer monolithic columns as a means to facilitate chemical transformations as well as both do
Autor:
Detlev Belder, Stefan Ohla
Publikováno v:
Current Opinion in Chemical Biology. 16:453-459
The hyphenation of miniaturized separation techniques like chip electrophoresis or chip chromatography to mass spectrometry (MS) is a highly active research area in modern separation science. Such methods are particularly attractive for comprehensive
Autor:
Petra Gläser, Kai Stockhausen, Stefanie Fritzsche, Christoph Schneider, Detlev Belder, Reinhild Beyreiss, Stefan Nagl, Stefan Ohla
Publikováno v:
Chemistry - A European Journal. 18:1240-1246
High-throughput screening for optimal reaction conditions and the search for efficient catalysts is of eminent importance in the development of chemical processes and for expanding the spectrum of synthetic methodologies in chemistry. In this context