Zobrazeno 1 - 10
of 552
pro vyhledávání: '"Stefan Offermanns"'
Autor:
Maryam Keshavarz, Anna-Lena Ruppert, Mirjam Meiners, Krupali Poharkar, Shuya Liu, Wafaa Mahmoud, Sarah Winterberg, Petra Hartmann, Petra Mermer, Alexander Perniss, Stefan Offermanns, Wolfgang Kummer, Burkhard Schütz
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-16 (2024)
Abstract Disorders of gallbladder motility can lead to serious pathology. Bitter tastants acting upon bitter taste receptors (TAS2R family) have been proposed as a novel class of smooth muscle relaxants to combat excessive contraction in the airways
Externí odkaz:
https://doaj.org/article/321211e0cffc423699dcbf34241b5d02
Autor:
Yundong Peng, Jingjing Du, Rui Li, Stefan Günther, Nina Wettschureck, Stefan Offermanns, Yan Wang, Andre Schneider, Thomas Braun
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-16 (2024)
Abstract Multiple processes control quiescence of muscle stem cells (MuSCs), which is instrumental to guarantee long-term replenishment of the stem cell pool. Here, we describe that the G-proteins G12-G13 integrate signals from different G-protein-co
Externí odkaz:
https://doaj.org/article/790430c2ddc44d10ac100c9cea1ebd1b
Autor:
Patrick J. Dörner, Harithaa Anandakumar, Ivo Röwekamp, Facundo Fiocca Vernengo, Belén Millet Pascual-Leone, Marta Krzanowski, Josua Sellmaier, Ulrike Brüning, Raphaela Fritsche-Guenther, Lennart Pfannkuch, Florian Kurth, Miha Milek, Vanessa Igbokwe, Ulrike Löber, Birgitt Gutbier, Markus Holstein, Gitta Anne Heinz, Mir-Farzin Mashreghi, Leon N. Schulte, Ann-Brit Klatt, Sandra Caesar, Sandra-Maria Wienhold, Stefan Offermanns, Matthias Mack, Martin Witzenrath, Stefan Jordan, Dieter Beule, Jennifer A. Kirwan, Sofia K. Forslund, Nicola Wilck, Hendrik Bartolomaeus, Markus M. Heimesaat, Bastian Opitz
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-14 (2024)
Abstract Hospital-acquired pneumonia (HAP) is associated with high mortality and costs, and frequently caused by multidrug-resistant (MDR) bacteria. Although prior antimicrobial therapy is a major risk factor for HAP, the underlying mechanism remains
Externí odkaz:
https://doaj.org/article/41a8a643c26b41c0b66352c312b98b9b
Autor:
Jenna Elizabeth Hunt, Charlotte Bayer Christiansen, Mohammad Yassin, Bolette Hartmann, Stefan Offermanns, Lars Ove Dragsted, Jens Juul Holst, Hannelouise Kissow
Publikováno v:
Metabolites, Vol 14, Iss 7, p 395 (2024)
Short-chain fatty acids (SCFAs) are the major microbial metabolites produced from the fermentation of dietary fiber in the gut. They are recognised as secretagogues of the glucagon-like peptides, GLP-1 and GLP-2, likely mediated by the activation of
Externí odkaz:
https://doaj.org/article/bd11afd979d249969949e34732c9668d
Endothelial FAT1 inhibits angiogenesis by controlling YAP/TAZ protein degradation via E3 ligase MIB2
Autor:
Rui Li, Jingchen Shao, Young-June Jin, Haruya Kawase, Yu Ting Ong, Kerstin Troidl, Qi Quan, Lei Wang, Remy Bonnavion, Astrid Wietelmann, Francoise Helmbacher, Michael Potente, Johannes Graumann, Nina Wettschureck, Stefan Offermanns
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
The authors report that endothelial protocadherin FAT1 inhibits endothelial proliferation and angiogenesis by promoting degradation of the transcriptional cofactors YAP and TAZ by direct interaction with the E3 ubiquitin ligase Mind Bomb-2 (MIB2).
Externí odkaz:
https://doaj.org/article/ae8cf225971e49d0b6bc0f0653d4b7c5
Publikováno v:
Frontiers in Pharmacology, Vol 14 (2023)
Atypical chemokine receptors (ACKRs) play pivotal roles in immune regulation by binding chemokines and regulating their spatial distribution without inducing G-protein activation. Recently, GPR182, provisionally named ACKR5, was identified as a novel
Externí odkaz:
https://doaj.org/article/855c917d6be54f478e8ec404be94568e
Autor:
ShengPeng Wang, Shuang Cao, Malika Arhatte, Dahui Li, Yue Shi, Sabrina Kurz, Jiong Hu, Lei Wang, Jingchen Shao, Ann Atzberger, Zheng Wang, Changhe Wang, Weijin Zang, Ingrid Fleming, Nina Wettschureck, Eric Honoré, Stefan Offermanns
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-3 (2022)
Externí odkaz:
https://doaj.org/article/aaa2335286cb4250b108a9e7aa59777e
Autor:
Malarvizhi Gurusamy, Denise Tischner, Jingchen Shao, Stephan Klatt, Sven Zukunft, Remy Bonnavion, Stefan Günther, Kai Siebenbrodt, Roxane-Isabelle Kestner, Tanja Kuhlmann, Ingrid Fleming, Stefan Offermanns, Nina Wettschureck
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
P2Y10 is a G-protein-coupled receptor that is expressed in CD4 T cells. Here authors show that its ligands, lysophosphatidylserine and ATP, are induced in T cells upon chemokine stimulation and regulate RhoA activation and migration through an autocr
Externí odkaz:
https://doaj.org/article/d43888793ed74435ad7482aecc577779
Autor:
Nils Helge Schebb, Hartmut Kühn, Astrid S. Kahnt, Katharina M. Rund, Valerie B. O’Donnell, Nicolas Flamand, Marc Peters-Golden, Per-Johan Jakobsson, Karsten H. Weylandt, Nadine Rohwer, Robert C. Murphy, Gerd Geisslinger, Garret A. FitzGerald, Julien Hanson, Claes Dahlgren, Mohamad Wessam Alnouri, Stefan Offermanns, Dieter Steinhilber
Publikováno v:
Frontiers in Pharmacology, Vol 13 (2022)
Formation of specialized pro-resolving lipid mediators (SPMs) such as lipoxins or resolvins usually involves arachidonic acid 5-lipoxygenase (5-LO, ALOX5) and different types of arachidonic acid 12- and 15-lipoxygenating paralogues (15-LO1, ALOX15; 1
Externí odkaz:
https://doaj.org/article/4d550b6401b044cfacb01d9180ee3c13
Autor:
Chen Jiang, Ahsan Javed, Laura Kaiser, Michele M. Nava, Rui Xu, Dominique T. Brandt, Dandan Zhao, Benjamin Mayer, Javier Fernández-Baldovinos, Luping Zhou, Carsten Höß, Kovilen Sawmynaden, Arkadiusz Oleksy, David Matthews, Lee S. Weinstein, Heidi Hahn, Hermann-Josef Gröne, Peter L. Graumann, Carien M. Niessen, Stefan Offermanns, Sara A. Wickström, Thomas Worzfeld
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of
Externí odkaz:
https://doaj.org/article/c31e77abae1d4cc9839c925693d0c2fb