Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Stefan O. Schönland"'
Autor:
Sara Karimi-Farsijani, Peter Benedikt Pfeiffer, Sambhasan Banerjee, Julian Baur, Lukas Kuhn, Niklas Kupfer, Ute Hegenbart, Stefan O. Schönland, Sebastian Wiese, Christian Haupt, Matthias Schmidt, Marcus Fändrich
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-8 (2024)
Abstract Systemic AL amyloidosis is one of the most frequently diagnosed forms of systemic amyloidosis. It arises from mutational changes in immunoglobulin light chains. To explore whether these mutations may affect the structure of the formed fibril
Externí odkaz:
https://doaj.org/article/a8a7533f549f4f7b811b7eb83658803c
Autor:
Maximilian Steinebrei, Julian Baur, Anaviggha Pradhan, Niklas Kupfer, Sebastian Wiese, Ute Hegenbart, Stefan O. Schönland, Matthias Schmidt, Marcus Fändrich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-8 (2023)
Abstract Systemic ATTR amyloidosis is an increasingly important protein misfolding disease that is provoked by the formation of amyloid fibrils from transthyretin protein. The pathological and clinical disease manifestations and the number of pathoge
Externí odkaz:
https://doaj.org/article/5116ea104f544636b03e07517f2cc3ed
Autor:
Jolanta B. Perz, Selma Gürel, Stefan O. Schonland, Ute Hegenbart, Anthony D. Ho, Peter Dreger
Publikováno v:
The Scientific World Journal, Vol 2012 (2012)
Background. The therapeutic efficacy of allogeneic hemopoietic stem cell transplantation (HSCT) largely relies on the graft-versus-leukemia (GVL) effect. Uncontrolled graft-versus-host disease (GVHD) is a feared complication of HSCT. Regulatory T cel
Externí odkaz:
https://doaj.org/article/b96f7012e2c34bc9abe46142d9fdaa8f
Autor:
Fabian aus dem Siepen, Selina Hein, Eva Hofmann, Christian Nagel, Stéphanie K. Schwarting, Ute Hegenbart, Stefan O. Schönland, Markus Weiler, Norbert Frey, Arnt V. Kristen
Publikováno v:
Journal of Clinical Medicine, Vol 13, Iss 8, p 2257 (2024)
Introduction: Cardiac transthyretin amyloidosis (ATTR) is a progressive, fatal disease leading to heart failure due to accumulation of amyloid fibrils in the interstitial space and may occur as a hereditary (ATTRv) or wild-type (ATTRwt) form. Guideli
Externí odkaz:
https://doaj.org/article/8d2c62e0ecc84a39858b681fea7d68e3
Autor:
Simone Feurstein, Julian Zoller, Constantin Schwab, Sarah Schreiner, Heiko Mundt, Iris Breitkreutz, Brigitte Schneider, Jörg Beimler, Martin Zeier, Rüdiger Waldherr, Stefan Gröschel, Carsten Müller‐Tidow, Stefan O. Schönland, Ute Hegenbart
Publikováno v:
eJHaem, Vol 3, Iss 4, Pp 1377-1380 (2022)
Abstract Due to differences in the protein folding mechanisms, it is exceedingly rare for amyloid light chain (AL) amyloidosis and monoclonal gammopathy of renal significance (MGRS) to coexist. We herein report the first case of concurrent AL amyloid
Externí odkaz:
https://doaj.org/article/762da7cf1a1d491ba281f9f797e23edf
Publikováno v:
Hemato, Vol 2, Iss 4, Pp 739-747 (2021)
Systemic amyloid light chain (AL) amyloidosis is a rare protein deposition disease caused by a clonal B cell disorder of the bone marrow. The underlying diseases can be plasma cell disorders (monoclonal gammopathy of clinical significance, smoldering
Externí odkaz:
https://doaj.org/article/e85be17af73640f68e0a151019ea8a58
Role of mutations and post-translational modifications in systemic AL amyloidosis studied by cryo-EM
Autor:
Lynn Radamaker, Sara Karimi-Farsijani, Giada Andreotti, Julian Baur, Matthias Neumann, Sarah Schreiner, Natalie Berghaus, Raoul Motika, Christian Haupt, Paul Walther, Volker Schmidt, Stefanie Huhn, Ute Hegenbart, Stefan O. Schönland, Sebastian Wiese, Clarissa Read, Matthias Schmidt, Marcus Fändrich
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains (LCs) but how post-translational modifications (PTMs) of LCs influence amyloid formation is not well understood. Here, the authors present the cryo-EM structure of an AL a
Externí odkaz:
https://doaj.org/article/0c01463d3d2340dc9ac1ed41d176f4a7
Autor:
Nora Liebers, Stefan O. Schönland, Claudius Speer, Dominic Edelmann, Paul Schnitzler, Hans-Georg Kräusslich, Carsten Mueller-Tidow, Ute Hegenbart, Sascha Dietrich
Publikováno v:
HemaSphere, Vol 6, Iss 3, p e688 (2022)
Externí odkaz:
https://doaj.org/article/a8fab26b967f41cc820e6e7d004e6860
Autor:
Jennifer Kollmer, Ute Hegenbart, Christoph Kimmich, Ernst Hund, Jan C. Purrucker, John M. Hayes, Stephen I. Lentz, Georges Sam, Johann M. E. Jende, Stefan O. Schönland, Martin Bendszus, Sabine Heiland, Markus Weiler
Publikováno v:
Annals of Clinical and Translational Neurology, Vol 7, Iss 5, Pp 799-807 (2020)
Abstract Objective To quantify peripheral nerve lesions in symptomatic and asymptomatic hereditary transthyretin amyloidosis with polyneuropathy (ATTRv‐PNP) by analyzing the magnetization transfer ratio (MTR) of the sciatic nerve, and to test its p
Externí odkaz:
https://doaj.org/article/9e22a57b5bc84ab196b434c089e25a39
Autor:
Lynn Radamaker, Yin-Hsi Lin, Karthikeyan Annamalai, Stefanie Huhn, Ute Hegenbart, Stefan O. Schönland, Günter Fritz, Matthias Schmidt, Marcus Fändrich
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-8 (2019)
Systemic AL amyloidosis is caused by misfolding of immunoglobulin light chains and is one of the most frequently occurring forms of systemic amyloidosis. Here the authors present the 3.3 Å cryo-EM structure of a λ1 AL amyloid fibril that was isolat
Externí odkaz:
https://doaj.org/article/b4de0969a221446794222489fd2110f9