Pilus-1 Backbone Protein RrgB of Streptococcus pneumoniae Binds Collagen I in a Force-Dependent Way

Autor: Tanja D Becke, Benedikt K Kaufmann, Markus Hilleringmann, Bastian Hartmann, Arndt F. Schilling, Stefanie Sudhop, Stefan Ness, Hauke Clausen-Schaumann

Publikováno v: ACS Nano. 13:7155-7165

Attachment to host tissue is a prerequisite for successful host colonization and invasion of pathogens. Many pathogenic bacteria use surface appendices, called pili, to bind and firmly attach to host tissue surfaces. Although it has been speculated t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d2950460026b1617e8455e35ac8119d
https://doi.org/10.1021/acsnano.9b02587

Nanometer-scale colocalization microscopy of Streptococcus pneumoniae filaments

Autor: Thomas Hellerer, Stefan Ness, Joachim O. Rädler, Markus Hilleringmann, Christoph Polzer, Mojtaba Mohseni

Publikováno v: Multiphoton Microscopy in the Biomedical Sciences XIX.

We present numerical simulations and experiments employing two-photon excited fluorescence in a sum-frequency mixing scheme which could be used for colocalization experiments in biophysics. By means of numerical calculations using the Debye approxima

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::961319a1a512a43b871030f67e387960
https://doi.org/10.1117/12.2509927

Single molecule force spectroscopy reveals two-domain binding mode of pilus-1 tip protein RrgA of $Streptococcus\ pneumoniae$ to fibronectin

Autor: Hauke Clausen-Schaumann, Raimund Gürster, Arndt F. Schilling, Tanja D Becke, Markus Hilleringmann, Stefanie Sudhop, Anne-Marie di Guilmi, Stefan Ness

Publikováno v: ACS Nano
ACS Nano, 2018, 12 (1), pp.549-558. ⟨10.1021/acsnano.7b07247⟩
ACS Nano, American Chemical Society, 2018, 12 (1), pp.549-558. ⟨10.1021/acsnano.7b07247⟩

International audience; For host cell adhesion and invasion, surface piliation procures benefits for bacteria. A detailed investigation of how pili adhere to host cells is therefore a key aspect inunderstanding their role during infection. Streptococ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ab9ce550f916d8b951192ac624ac7e9
https://hal.science/hal-01871819

High class filtering facepiece (FFP) are fundamental and effective in protection of emergency health care workers: an observational cohort study in a German community

Autor: Martin Lier, Stefan Nessler, Christine Stadelmann, Meike Pressler, Leif Saager, Onnen Moerer, Markus Roessler, Konrad Meissner, Martin S. Winkler

Publikováno v: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, Vol 29, Iss 1, Pp 1-8 (2021)

Abstract Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a highly contagious airborne virus inducing pandemic coronavirus disease 2019 (COVID-19). This is most relevant for medical staff working under harmful conditions in

Externí odkaz: https://doaj.org/article/75f07f3a1ee8482aa233986f6ebc10e1

Laquinimod, a prototypic quinoline-3-carboxamide and aryl hydrocarbon receptor agonist, utilizes a CD155-mediated natural killer/dendritic cell interaction to suppress CNS autoimmunity

Autor: Martina Ott, Erika Avendaño-Guzmán, Evelyn Ullrich, Carolin Dreyer, Judith Strauss, Markus Harden, Margarete Schön, Michael P. Schön, Günter Bernhardt, Christine Stadelmann, Christiane Wegner, Wolfgang Brück, Stefan Nessler

Publikováno v: Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-14 (2019)

Abstract Background Quinoline-3-carboxamides, such as laquinimod, ameliorate CNS autoimmunity in patients and reduce tumor cell metastasis experimentally. Previous studies have focused on the immunomodulatory effect of laquinimod on myeloid cells. Th

Externí odkaz: https://doaj.org/article/90d464c07a57445085067be6d19305d1