Zobrazeno 1 - 10
of 347
pro vyhledávání: '"Stefan Nagel"'
Autor:
Claudia Pommerenke, Stefan Nagel, Josephine Haake, Anne Leena Koelz, Matthias Christgen, Laura Steenpass, Sonja Eberth
Publikováno v:
Cells, Vol 13, Iss 4, p 301 (2024)
Continuous cell lines are important and commonly used in vitro models in breast cancer (BC) research. Selection of the appropriate model cell line is crucial and requires consideration of their molecular characteristics. To characterize BC cell line
Externí odkaz:
https://doaj.org/article/ea4b80a08e65486fab2bb1ae04c6a80b
Autor:
Stefan Nagel
Publikováno v:
Hemato, Vol 3, Iss 1, Pp 122-130 (2022)
Homeobox genes encode transcription factors which control basic processes in development and differentiation. Concerning the sequence conservation in their homeobox, these genes are arranged into particular groups sharing evolutionary ancestry and re
Externí odkaz:
https://doaj.org/article/f868a9118ea04d46afb54211a860cf1b
Autor:
Hilmar Quentmeier, Robert Geffers, Vivien Hauer, Stefan Nagel, Claudia Pommerenke, Cord C. Uphoff, Margarete Zaborski, Hans G. Drexler
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Overexpression of antiapoptotic BCL2 family proteins occurs in various hematologic malignancies and contributes to tumorigenesis by inhibiting the apoptotic machinery of the cells. Antagonizing BH3 mimetics provide an option for medication,
Externí odkaz:
https://doaj.org/article/88679ebb5bbd4ac6816fcd6fc2d8f448
Publikováno v:
Biomedicines, Vol 11, Iss 6, p 1758 (2023)
BCL2, BCL6 and MYC are major oncogenes in B-cell lymphoma. Their aberrant activation frequently occurs via chromosomal translocations which juxtapose light or heavy chain immunoglobulin (IG) genes to BCL2 and MYC or fuse diverse partner genes with BC
Externí odkaz:
https://doaj.org/article/1cc3952e69e843bea82777582badeeab
Autor:
Stefan Nagel, Sonja Eberth, Laura Steenpass, Claudia Pommerenke, Wilhelm G. Dirks, Julia Koblitz
Publikováno v:
F1000Research, Vol 11 (2022)
Human and animal cell lines serve as model systems in a wide range of life sciences such as cancer and infection research or drug screening. Reproducible data are highly dependent on authenticated, contaminant-free cell lines, no better delivered tha
Externí odkaz:
https://doaj.org/article/e68c970fe7b9451caf44f26779bf6719
Publikováno v:
Current Oncology, Vol 28, Iss 3, Pp 1790-1794 (2021)
Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm that is genetically characterized by the absence of both the Philadelphia chromosome and BCR-ABL1 fusion gene and the high prevalence of mutations in the colony-stimulating fac
Externí odkaz:
https://doaj.org/article/8828deb130924eedbe201cca04f88164
Genomic Aberrations Generate Fusion Gene FOXK2::TP63 and Activate NFKB1 in Cutaneous T-Cell Lymphoma
Autor:
Stefan Nagel, Claudia Pommerenke, Hilmar Quentmeier, Corinna Meyer, Maren Kaufmann, Roderick A. F. MacLeod
Publikováno v:
Biomedicines, Vol 10, Iss 8, p 2038 (2022)
Cutaneous T-cell lymphoma (CTCL) is a severe lymphoid malignancy with a worse prognosis lacking curative treatment regimens. Several gene mutations and deregulated pathways, including NFkB signaling, have been implicated in its pathogenesis. Accordin
Externí odkaz:
https://doaj.org/article/27b1710692744292a7cc0ec82ae457a5
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1608 (2022)
STAT3 is a transcription factor which is activated via various signaling transduction pathways or Epstein-Barr virus (EBV) infection and plays an oncogenic role in lymphoid malignancies including Hodgkin lymphoma (HL). The tumor cells of HL are deriv
Externí odkaz:
https://doaj.org/article/c6aa5131ed5c4c9dad4a943927272870
Autor:
Claudia Pommerenke, Ulfert Rand, Cord C. Uphoff, Stefan Nagel, Margarete Zaborski, Vivien Hauer, Maren Kaufmann, Corinna Meyer, Sabine A. Denkmann, Peggy Riese, Kathrin Eschke, Yeonsu Kim, Zeljka Macak Safranko, Ivan-Christian Kurolt, Alemka Markotic, Luka Cicin-Sain, Laura Steenpass
Publikováno v:
PLoS ONE, Vol 16, Iss 8 (2021)
The SARS-CoV-2 pandemic is a major global threat that sparked global research efforts. Pre-clinical and biochemical SARS-CoV-2 studies firstly rely on cell culture experiments where the importance of choosing an appropriate cell culture model is ofte
Externí odkaz:
https://doaj.org/article/2a2ec419ed7a4a3d88b5040433351035
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0246603 (2021)
Homeobox genes encode transcription factors which regulate basic processes in development and cell differentiation and are grouped into classes and subclasses according to sequence similarities. Here, we analyzed the activities of the 20 members stro
Externí odkaz:
https://doaj.org/article/0a399c097c4a46afb71ac25639ced821