Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Stefan Mikkat"'
Autor:
Moritz K. Jansson, Dat Tien Nguyen, Stefan Mikkat, Carolin Warnke, Marc Benjamin Janssen, Philipp Warnke, Bernd Kreikemeyer, Nadja Patenge
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 35, Iss 1, Pp 102145- (2024)
Endolysins are bacteriophage-encoded hydrolases that show high antibacterial activity and a narrow substrate spectrum. We hypothesize that an mRNA-based approach to endolysin therapy can overcome some challenges of conventional endolysin therapy, nam
Externí odkaz:
https://doaj.org/article/71327c5d2366410a952eb70253ae1aaa
Publikováno v:
Microorganisms, Vol 12, Iss 8, p 1556 (2024)
Phosphoglycerylation is a non-enzymatic protein modification in which a phosphoglyceryl moiety is covalently bound to the ε-amino group of lysine. It is enriched in glycolytic enzymes from humans and mice and is thought to provide a feedback mechani
Externí odkaz:
https://doaj.org/article/f0498364faf24c6f88205104326b229a
Publikováno v:
Microorganisms, Vol 12, Iss 3, p 621 (2024)
Phosphorylation of proteins at serine, threonine, and tyrosine residues plays an important role in physiological processes of bacteria, such as cell cycle, metabolism, virulence, dormancy, and stationary phase functions. Little is known about the tar
Externí odkaz:
https://doaj.org/article/a09f6d870f2843e9a8204c628445bcb0
Autor:
Khadijeh Ghasemian, Inge Broer, Jennifer Schön, Nadine Kolp, Richard Killisch, Stefan Mikkat, Jana Huckauf
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
Rodent population control through contraception requires species-specific oral contraceptive vaccines. Therefore, in this study, we produced putative mouse-specific contraceptive peptides, mZP2 (from oocyte) and mIzumo1 (from sperm), in plants using
Externí odkaz:
https://doaj.org/article/8a2166d0da9e431ab8506c96c47e3d9d
Autor:
Stephan Klähn, Stefan Mikkat, Matthias Riediger, Jens Georg, Wolfgang R. Hess, Martin Hagemann
Publikováno v:
Biology Direct, Vol 16, Iss 1, Pp 1-23 (2021)
Abstract Microorganisms evolved specific acclimation strategies to thrive in environments of high or fluctuating salinities. Here, salt acclimation in the model cyanobacterium Synechocystis sp. PCC 6803 was analyzed by integrating transcriptomic, pro
Externí odkaz:
https://doaj.org/article/ae623947ce7348e78dc4954596555649
Autor:
Juliane Köhler, Claudia Maletzki, Dirk Koczan, Marcus Frank, Armin Springer, Carolin Steffen, Alexey S. Revenko, A.Robert MacLeod, Stefan Mikkat, Bernd Kreikemeyer, Sonja Oehmcke-Hecht
Publikováno v:
EBioMedicine, Vol 58, Iss , Pp 102908- (2020)
Background: High-molecular-weight kininogen is a cofactor of the human contact system, an inflammatory response mechanism that is activated during sepsis. It has been shown that high-molecular-weight kininogen contributes to endotoxemia, but is not c
Externí odkaz:
https://doaj.org/article/03c0be58cc2b4ae5b6157e4c68ca453c
Autor:
Juliane Köhler, Claudia Maletzki, Dirk Koczan, Marcus Frank, Carolin Trepesch, Alexey S. Revenko, Jeffrey R. Crosby, A. Robert Macleod, Stefan Mikkat, Sonja Oehmcke-Hecht
Publikováno v:
Haematologica, Vol 105, Iss 5 (2020)
Sepsis causes an activation of the human contact system, an inflammatory response mechanism against foreign surfaces, proteins and pathogens. The serine proteases of the contact system, factor XII and plasma kallikrein, are decreased in plasma of sep
Externí odkaz:
https://doaj.org/article/c9b6d71a7980459191b8df8179aeef1d
Autor:
Anna-Lena Buschhart, Lennart Bolten, Johann Volzke, Katharina Ekat, Susanne Kneitz, Stefan Mikkat, Bernd Kreikemeyer, Brigitte Müller-Hilke
Publikováno v:
PLoS ONE, Vol 15, Iss 12, p e0242868 (2020)
Rheumatoid arthritis (RA) and periodontitis (PD) are chronic inflammatory diseases that appear to occur in tandem. However, the mutual impact PD exerts on RA and vice versa has not yet been defined. To address this issue, we set up an animal model an
Externí odkaz:
https://doaj.org/article/a01231471e0e41a582ee9d66ed933b05
Autor:
Katrin Gärtner, Stephan Klähn, Satoru Watanabe, Stefan Mikkat, Ingeborg Scholz, Wolfgang R. Hess, Martin Hagemann
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
DNA methylation plays a crucial role for gene regulation among eukaryotes, but its regulatory function is less documented in bacteria. In the cyanobacterium Synechocystis sp. PCC 6803 five DNA methyltransferases have been identified. Among them, M.Ss
Externí odkaz:
https://doaj.org/article/7a063649225c43a0a83186881275ac09
Autor:
Paula Alexandra Postu, Dragos Lucian Gorgan, Oana Cioanca, Manuela Russ, Stefan Mikkat, Michael Otto Glocker, Lucian Hritcu
Publikováno v:
Antioxidants, Vol 9, Iss 10, p 919 (2020)
Origanum L. (Lamiaceae) is an important genus of medicinal and aromatic plants used in traditional medicine since ancient times as culinary herbs and remedies. The aim of the present study was to evaluate the chemical composition, as well as the bioc
Externí odkaz:
https://doaj.org/article/ed32f0c4ef634726b067c7e623744aba