Zobrazeno 1 - 10
of 129
pro vyhledávání: '"Stefan M.V. Freund"'
Regulation of CYLD activity and specificity by phosphorylation and ubiquitin-binding CAP-Gly domains
Autor:
Paul R. Elliott, Derek Leske, Jane Wagstaff, Lisa Schlicher, Georgina Berridge, Sarah Maslen, Frederik Timmermann, Biao Ma, Roman Fischer, Stefan M.V. Freund, David Komander, Mads Gyrd-Hansen
Publikováno v:
Cell Reports, Vol 37, Iss 1, Pp 109777- (2021)
Summary: Non-degradative ubiquitin chains and phosphorylation events govern signaling responses by innate immune receptors. The deubiquitinase CYLD in complex with SPATA2 is recruited to receptor signaling complexes by the ubiquitin ligase LUBAC and
Externí odkaz:
https://doaj.org/article/d571de542e024e62ba236d09ebae7842
Autor:
Nimesh Joseph, Caezar Al-Jassar, Christopher M. Johnson, Antonina Andreeva, Deepak D. Barnabas, Stefan M.V. Freund, Fanni Gergely, Mark van Breugel
Publikováno v:
Cell Reports, Vol 23, Iss 9, Pp 2805-2818 (2018)
Ciliopathies are a group of genetic disorders caused by a failure to form functional cilia. Due to a lack of structural information, it is currently poorly understood how ciliopathic mutations affect protein functionality to give rise to the underlyi
Externí odkaz:
https://doaj.org/article/829808a7b77b4cf399b1c20cde909bcc
Autor:
Jonathon Nixon-Abell, Francesco S. Ruggeri, Seema Qamar, Therese W. Herling, Magdalena A. Czekalska, Yi Shen, Guozhen Wang, Christopher King, Michael S. Fernandopulle, Tomas Sneideris, Joseph L. Watson, Visakh V.S. Pillai, William Meadows, James W. Henderson, Joseph E. Chambers, Jane L. Wagstaff, Sioned H. Williams, Helena Coyle, Yuqian Lu, Shuyuan Zhang, Stefan J. Marciniak, Stefan M.V. Freund, Emmanuel Derivery, Michael E. Ward, Michele Vendruscolo, Tuomas P.J. Knowles, Peter St George-Hyslop
Publikováno v:
bioRxiv
SUMMARYPhase transitions of cellular proteins and lipids play a key role in governing the organisation and coordination of intracellular biology. The frequent juxtaposition of proteinaceous biomolecular condensates to cellular membranes raises the in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33defe860df5665cc889d6dd86e39881
https://europepmc.org/articles/PMC10055329/
https://europepmc.org/articles/PMC10055329/
Autor:
Xiao-Han Li, Conny W.H. Yu, Natalia Gomez-Navarro, Viktoriya Stancheva, Hongni Zhu, Cristina Guibao, Andal Murthy, Boer Xie, Michael Wozny, Benjamin Leslie, Marcin Kaminski, Ketan Malhotra, Christopher M. Johnson, Martin Blackledge, Balaji Santhanam, Douglas R. Green, Junmin Peng, Wei Liu, Jinqing Huang, Elizabeth A. Miller, Stefan M.V. Freund, M. Madan Babu
SummaryEnvironmental stress can result in substantial damage to proteins, membranes, and genetic material, impacting organismal survival1-3. Stress tolerance can be conferred by intrinsically disordered proteins (IDPs)4 that lack stable tertiary stru
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7a953ddcab58358683a9ee5b7f718b86
https://doi.org/10.1101/2022.07.29.502075
https://doi.org/10.1101/2022.07.29.502075
Autor:
Hans-Georg Kräusslich, Xiaoli Xiong, John A. G. Briggs, Susann Kummer, Leslie J. Calder, Stefan M.V. Freund, Julia Peukes, Oliver Schraidt, Kun Qu, Simon Erlendsson, William Wan
Publikováno v:
Nature
Influenza A virus causes millions of severe cases of disease during annual epidemics. The most abundant protein in influenza virions is matrix protein 1 (M1), which mediates virus assembly by forming an endoskeleton beneath the virus membrane1. The s
Autor:
Sarah L. Maslen, Shun-ichiro Oda, Frank Adolf, Yorgo Modis, Iva A. Tchasovnikarova, Christopher H. Douse, Paul J. Lehner, Daniil M. Prigozhin, Stefan M.V. Freund, Anna Albecka, Laura E. Farleigh, Richard T. Timms
Publikováno v:
Nucleic Acids Research
Nucleic acids research, vol 48, iss 18
Nucleic acids research, vol 48, iss 18
Transcription of integrated DNA from viruses or transposable elements is tightly regulated to prevent pathogenesis. The Human Silencing Hub (HUSH), composed of Periphilin, TASOR and MPP8, silences transcriptionally active viral and endogenous transge
Autor:
Ananthanarayanan Kumar, Xiao-Han Li, Stefan M.V. Freund, Lori A. Passmore, Juan B. Rodríguez-Molina, Conny Wing-Heng Yu
Cleavage and polyadenylation factor (CPF/CPSF) is a multiprotein complex essential for mRNA 3’-end processing in eukaryotes. It contains an endonuclease that cleaves pre-mRNAs, and a polymerase that adds a poly(A) tail onto the cleaved 3’-end. Se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2bffea6d024cb51f6ad1fe5f31e1270f
https://doi.org/10.1101/2021.07.07.451483
https://doi.org/10.1101/2021.07.07.451483
Autor:
Madhanagopal Anandapadamanaban, Andreas Boland, Alex Berndt, Olga Perisic, Xiaodan Ni, Stefan M.V. Freund, Jane L. Wagstaff, Roger L. Williams, Sarah L. Maslen, Stephen H. McLaughlin, Keitaro Yamashita, Conny Wing-Heng Yu, Mark Skehel, Maren Heimhalt, Garib N. Murshudov, Glenn R. Masson
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c63a7d4c77d781be24fc078b87ff7f22
https://doi.org/10.7554/elife.68799.sa2
https://doi.org/10.7554/elife.68799.sa2
Autor:
Mariann Bienz, Gonzalo J Beitia, Stefan M.V. Freund, Melissa V. Gammons, Hugh R.B. Pelham, Trevor J. Rutherford
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We report a Dishevelled structural clamp, a β-sheet containing a conserved phosphorylation site immediately upstream of the Dishevelled, Egl-10, and Pleckstrin (DEP) domain, contacting a cognate surface on its partner DEP domain to stab
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Communications Biology
Communications Biology
SWI/SNF (BAF) chromatin remodelling complexes are key regulators of gene expression programs, and attractive drug targets for cancer therapies. Here we show that the N-terminus of the BAF155/SMARCC1 subunit contains a putative DNA-binding MarR-like d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69c4bdf9ea144318a74d96ba167971e8