Zobrazeno 1 - 10 of 248 pro vyhledávání: '"Stefan M Willems"'
1
Akademický článek
Absence of PD-L1 expression on tumor cells in the context of an activated immune infiltrate may indicate impaired IFNγ signaling in non-small cell lung cancer.
Autor: Willemijn S M E Theelen, Thomas Kuilman, Katja Schulze, Wei Zou, Oscar Krijgsman, Dennis D G C Peters, Sten Cornelissen, Kim Monkhorst, Pranamee Sarma, Teiko Sumiyoshi, Lukas C Amler, Stefan M Willems, Johannes L G Blaauwgeers, Carel J M van Noesel, Daniel S Peeper, Michel M van den Heuvel, Marcin Kowanetz
Publikováno v: PLoS ONE, Vol 14, Iss 5, p e0216864 (2019)
BackgroundIn non-small cell lung cancer (NSCLC), PD-L1 expression on either tumor cells (TC) or both TC and tumor-infiltrating immune cells (IC) is currently the most used biomarker in cancer immunotherapy. However, the mechanisms involved in PD-L1 r
Externí odkaz: https://doaj.org/article/71ec07804c5045b0afac420650e42855
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2
Akademický článek
Spatial correlation between in vivo imaging and immunohistochemical biomarkers: A methodological study
Autor: Hilde J.G. Smits, Edwin Bennink, Lilian N. Ruiter, Gerben E. Breimer, Stefan M. Willems, Jan W. Dankbaar, Marielle E.P. Philippens
Publikováno v: Translational Oncology, Vol 48, Iss , Pp 102051- (2024)
In this study, we present a method that enables voxel-by-voxel comparison of in vivo imaging to immunohistochemistry (IHC) biomarkers. As a proof of concept, we investigated the spatial correlation between dynamic contrast enhanced (DCE-)CT parameter
Externí odkaz: https://doaj.org/article/7f3ffab99c6a46f1a57a9a9397a01029
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3
Akademický článek
Targeted Next Generation Sequencing as a Reliable Diagnostic Assay for the Detection of Somatic Mutations in Tumours Using Minimal DNA Amounts from Formalin Fixed Paraffin Embedded Material.
Autor: Wendy W J de Leng, Christa G Gadellaa-van Hooijdonk, Françoise A S Barendregt-Smouter, Marco J Koudijs, Ies Nijman, John W J Hinrichs, Edwin Cuppen, Stef van Lieshout, Robert D Loberg, Maja de Jonge, Emile E Voest, Roel A de Weger, Neeltje Steeghs, Marlies H G Langenberg, Stefan Sleijfer, Stefan M Willems, Martijn P Lolkema
Publikováno v: PLoS ONE, Vol 11, Iss 2, p e0149405 (2016)
Targeted Next Generation Sequencing (NGS) offers a way to implement testing of multiple genetic aberrations in diagnostic pathology practice, which is necessary for personalized cancer treatment. However, no standards regarding input material have be
Externí odkaz: https://doaj.org/article/d24f1077607043a59bda3a036165608a
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4
Akademický článek
Combined spatial Keratin expression profiles at the invasive front represent a prognostic classifier for head and neck cancer
Autor: Peter D. Haughton, Wisse E. Haakma, Sven van Kempen, Emma J. de Ruiter, Stefan M. Willems, Patrick W.B. Derksen
Publikováno v: Oral Oncology Reports, Vol 10, Iss , Pp 100394- (2024)
Keratin proteins are intermediate filaments that provide mechanical support and guide a plethora of important functions in epithelial cells. Although Keratins can be effectively used to characterize and differentiate cell lineages in many epithelia,
Externí odkaz: https://doaj.org/article/6f72331067d14bde9f2b95b30bc56274
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5
Akademický článek
Validation of automated positive cell and region detection of immunohistochemically stained laryngeal tumor tissue using digital image analysis
Autor: Hilde J.G. Smits, Justin E. Swartz, Marielle E.P. Philippens, Remco de Bree, Johannes H.A.M. Kaanders, Sjors A. Koppes, Gerben E. Breimer, Stefan M. Willems
Publikováno v: Journal of Pathology Informatics, Vol 14, Iss , Pp 100198- (2023)
Objectives: This study aimed to validate a digital image analysis (DIA) workflow for automatic positive cell detection and positive region delineation for immunohistochemical hypoxia markers with a nuclear (hypoxia-inducible factor 1α [HIF-1α]) and
Externí odkaz: https://doaj.org/article/96e24757cb57430cb275f68a69b3f140
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7
Akademický článek
One-fits-all pretreatment protocol facilitating Fluorescence In Situ Hybridization on formalin-fixed paraffin-embedded, fresh frozen and cytological slides
Autor: Shivanand O. Richardson, Manon M. H. Huibers, Roel A. de Weger, Wendy W. J. de Leng, John W. J. Hinrichs, Ruud W. J. Meijers, Stefan M. Willems, Ton L. M. G. Peeters
Publikováno v: Molecular Cytogenetics, Vol 12, Iss 1, Pp 1-10 (2019)
Abstract Background The Fluorescence In Situ Hybridization (FISH) technique is a very useful tool for diagnostic and prognostic purposes in molecular pathology. However, clinical testing on patient tissue is challenging due to variables of tissue pro
Externí odkaz: https://doaj.org/article/95496c3b8ec54bfa951f5d85ad793295
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8
Akademický článek
Detection of NTRK Fusions and TRK Expression and Performance of pan-TRK Immunohistochemistry in Routine Diagnostics: Results from a Nationwide Community-Based Cohort
Autor: Bart Koopman, Chantal C. H. J. Kuijpers, Harry J. M. Groen, Wim Timens, Ed Schuuring, Stefan M. Willems, Léon C. van Kempen
Publikováno v: Diagnostics, Vol 12, Iss 3, p 668 (2022)
Gene fusions involving NTRK1, NTRK2, and NTRK3 are rare drivers of cancer that can be targeted with histology-agnostic inhibitors. This study aimed to determine the nationwide landscape of NTRK/TRK testing in the Netherlands and the usage of pan-TRK
Externí odkaz: https://doaj.org/article/4163d8a721c54c0cae77f51cbd47b9db
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9
Nationwide differences in cytology fixation and processing methods and their impact on interlaboratory variation in PD-L1 positivity
Autor: Bregje M. Koomen, Mirthe de Boer, Carmen van Dooijeweert, Anne S. R. van Lindert, Ivette A. G. Deckers, Quirinus J. M. Voorham, Stefan M. Willems
Publikováno v: Virchows Archiv, 707–720. SPRINGER
Programmed death ligand-1 (PD-L1) immunostaining, which aids clinicians in decision-making on immunotherapy for non-small cell lung cancer (NSCLC) patients, is sometimes performed on cytological specimens. In this study, differences in cytology fixat
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd2015ab99de6706def86ddfa8e43ea8
https://doi.org/10.1007/s00428-022-03446-w
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10
Assessing the prognostic value of tumor-infiltrating CD57+ cells in advanced stage head and neck cancer using QuPath digital image analysis
Autor: Emma J. de Ruiter, Sangeeta K. Bisheshar, Reinout H. de Roest, Frederik W. R. Wesseling, Frank J. P. Hoebers, Mari F. C. M. van den Hout, C. René Leemans, Ruud H. Brakenhoff, Remco de Bree, Chris H. J. Terhaard, Stefan M. Willems
Publikováno v: Virchows Archiv, 481(2), 223-231. Springer, Cham
Virchows Archiv, 481(2), 223-231. SPRINGER
Virchows Archiv, 481(2), 223-231. Springer Verlag
de Ruiter, E J, Bisheshar, S K, de Roest, R H, Wesseling, F W R, Hoebers, F J P, van den Hout, M F C M, Leemans, C R, Brakenhoff, R H, de Bree, R, Terhaard, C H J & Willems, S M 2022, ' Assessing the prognostic value of tumor-infiltrating CD57+ cells in advanced stage head and neck cancer using QuPath digital image analysis ', Virchows Archiv, vol. 481, no. 2, pp. 223-231 . https://doi.org/10.1007/s00428-022-03323-6
This study aimed to assess the prognostic value of intratumoral CD57+ cells in head and neck squamous cell carcinoma (HNSCC) and to examine the reproducibility of these analyses using QuPath. Pretreatment biopsies of 159 patients with HPV-negative, s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::222fa8582d356a38b9827ed30e88c2ab
https://doi.org/10.1007/s00428-022-03323-6
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