Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Stefan M V Freund"'
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e48252 (2012)
The tumour suppressor p53 controls transcription of various genes involved in apoptosis, cell-cycle arrest, DNA repair and metabolism. However, its DNA-recognition specificity is not nearly sufficient to explain binding to specific locations in vivo.
Externí odkaz:
https://doaj.org/article/d850e05a4903400c91ade8c35fc6b816
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-7 (2021)
Allen et al. determine crystal structure of the N-terminus of SWI/SNF chromatin remodelling factor subunit BAF155. They identify an interconnected structure of MarR-like, BRCT and chromodomains, visualise the potential effect of cancer-associated mis
Externí odkaz:
https://doaj.org/article/0c57c506282247f9b60c617c12226435
Autor:
Christopher H. Douse, Iva A. Tchasovnikarova, Richard T. Timms, Anna V. Protasio, Marta Seczynska, Daniil M. Prigozhin, Anna Albecka, Jane Wagstaff, James C. Williamson, Stefan M. V. Freund, Paul J. Lehner, Yorgo Modis
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
The HUSH complex plays a key role in controlling transcription of viruses and transposable elements. Here, the authors define the biochemical basis of HUSH assembly and show that the TASOR subunit contains a pseudo-PARP domain critical for HUSH-depen
Externí odkaz:
https://doaj.org/article/ec9909b7b0774e2691625135a2850ac1
Autor:
Yi Liu, Gagan D. Gupta, Deepak D. Barnabas, Fikret G. Agircan, Shahid Mehmood, Di Wu, Etienne Coyaud, Christopher M. Johnson, Stephen H. McLaughlin, Antonina Andreeva, Stefan M. V. Freund, Carol V. Robinson, Sally W. T. Cheung, Brian Raught, Laurence Pelletier, Mark van Breugel
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
Centriole duplication is tightly regulated in vivo, but the underlying molecular mechanisms are incompletely understood. Here the authors use high-resolution structural and imaging methods to show that CEP85 directly interacts with STIL and mediates
Externí odkaz:
https://doaj.org/article/64d5bf6e3d9f4b17ae080b2ad6edfff9
Autor:
Tim Nierhaus, Stephen H. McLaughlin, Frank Bürmann, Danguole Kureisaite-Ciziene, Sarah L. Maslen, J. Mark Skehel, Conny W. H. Yu, Stefan M. V. Freund, Louise F. H. Funke, Jason W. Chin, Jan Löwe
Publikováno v:
Nature Microbiology. 7:1686-1701
During bacterial cell division, filaments of tubulin-like FtsZ form the Z-ring, which is the cytoplasmic scaffold for divisome assembly. In Escherichia coli, the actin homologue FtsA anchors the Z-ring to the membrane and recruits divisome components
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c86d9870695cc5a6de38f025a15dd11
https://doi.org/10.1038/s41564-022-01206-9
https://doi.org/10.1038/s41564-022-01206-9
Autor:
Elyse S, Fischer, Conny W H, Yu, Johannes F, Hevler, Stephen H, McLaughlin, Sarah L, Maslen, Albert J R, Heck, Stefan M V, Freund, David, Barford
Publikováno v:
Nature communications. 13(1)
In response to improper kinetochore-microtubule attachments in mitosis, the spindle assembly checkpoint (SAC) assembles the mitotic checkpoint complex (MCC) to inhibit the anaphase-promoting complex/cyclosome, thereby delaying entry into anaphase. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c2576136482f14d328d3953495646347
https://pubmed.ncbi.nlm.nih.gov/36289199
https://pubmed.ncbi.nlm.nih.gov/36289199
Autor:
George S. Biggs, Oskar James Klein, Sarah L. Maslen, J. Mark Skehel, Trevor J. Rutherford, Stefan M. V. Freund, Florian Hollfelder, Sally R. Boss, Paul D. Barker
Publikováno v:
Angewandte Chemie International Edition
Angewandte Chemie (International Ed. in English)
Angewandte Chemie (International Ed. in English)
Many natural metalloenzymes assemble from proteins and biosynthesised complexes, generating potent catalysts by changing metal coordination. Here we adopt the same strategy to generate artificial metalloenzymes (ArMs) using ligand exchange to unmask
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::07e57215e0d0daef42c1a3e575a5d36b
https://www.repository.cam.ac.uk/handle/1810/321567
https://www.repository.cam.ac.uk/handle/1810/321567
Autor:
Anita K, Ho, Jane L, Wagstaff, Paul T, Manna, Lena, Wartosch, Seema, Qamar, Elspeth F, Garman, Stefan M V, Freund, Rhys C, Roberts
Publikováno v:
BMC Biology
Background Mutations in Lipopolysaccharide-induced tumour necrosis factor-α factor (LITAF) cause the autosomal dominant inherited peripheral neuropathy, Charcot-Marie-Tooth disease type 1C (CMT1C). LITAF encodes a 17 kDa protein containing an N-term
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::15e79749af59ee8fa339c4af51274bc0
https://doi.org/10.1186/s12915-016-0332-8
https://doi.org/10.1186/s12915-016-0332-8
Autor:
Bernhard C, Lechtenberg, Mark D, Allen, Trevor J, Rutherford, Stefan M V, Freund, Mark, Bycroft
Publikováno v:
Protein science : a publication of the Protein Society. 18(3)
Polycomb group proteins are epigenetic regulators that maintain patterns of gene expression over multiple rounds of cell division. Many of these proteins, including polyhomeotic and the MBT repeat containing proteins SCM and dSfmbt, contain an atypic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4766bf817a577e0a6b5d49cc9765fd1d
https://pubmed.ncbi.nlm.nih.gov/19241375
https://pubmed.ncbi.nlm.nih.gov/19241375
Autor:
Elliott J, Stollar, Ugo, Mayor, Simon C, Lovell, Luca, Federici, Stefan M V, Freund, Alan R, Fersht, Ben F, Luisi
Publikováno v:
The Journal of biological chemistry. 278(44)
We report the crystal structures and biophysical characterization of two stabilized mutants of the Drosophila Engrailed homeodomain that have been engineered to minimize electrostatic repulsion. Four independent copies of each mutant occupy the cryst
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::908fc5bf7cfd2d25de59de12876a455b
https://pubmed.ncbi.nlm.nih.gov/12923178
https://pubmed.ncbi.nlm.nih.gov/12923178