Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Stefan M, Noha"'
Autor:
Stefan M. Noha, Chao Wang, Yan Niu, Hongyue Li, Dandan Xi, Fengrong Xu, Ping Xu, Veronika Temml, Daniela Schuster
Publikováno v:
European Journal of Medicinal Chemistry. 178:802-817
We report in this work the discovery of novel allosteric MEK inhibitors by pharmacophore modeling and virtual screening. Two out of 13 virtual hit compounds were identified as MEK kinase inhibitors using a MEK1 binding assay. Structural derivations o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4976ab58129690ec763775e50ab23f1c
https://doi.org/10.1016/j.ejmech.2019.06.027
https://doi.org/10.1016/j.ejmech.2019.06.027
Autor:
Atanas G Atanasov, Martina Blunder, Nanang Fakhrudin, Xin Liu, Stefan M Noha, Clemens Malainer, Matthias P Kramer, Amina Cocic, Olaf Kunert, Andreas Schinkovitz, Elke H Heiss, Daniela Schuster, Verena M Dirsch, Rudolf Bauer
Publikováno v:
PLoS ONE, Vol 8, Iss 4, p e61755 (2013)
Peroxisome proliferator-activated receptor gamma (PPARγ) is a key regulator of glucose and lipid metabolism and therefore an important pharmacological target to combat metabolic diseases. Since the currently used full PPARγ agonists display serious
Externí odkaz:
https://doaj.org/article/b576503ce8344f05a6585e83cfecfe37
Autor:
Maria, Dumitrascuta, Tanila, Ben Haddou, Elena, Guerrieri, Stefan M, Noha, Lea, Schläfer, Helmut, Schmidhammer, Mariana, Spetea
Publikováno v:
Journal of Medicinal Chemistry
Position 6 of the morphinan skeleton plays a key role in the μ-opioid receptor (MOR) activity in vitro and in vivo. We describe the consequence of the 6-carbonyl group deletion in N-methylmorphinan-6-ones 1–4 on ligand–MOR interaction, signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::79b5b040f59c3345eb1b02f4505a6477
https://pubmed.ncbi.nlm.nih.gov/29053268
https://pubmed.ncbi.nlm.nih.gov/29053268
Publikováno v:
ACS Chemical Neuroscience
Among opioids, morphinans are of major importance as the most effective analgesic drugs acting primarily via μ-opioid receptor (μ-OR) activation. Our long-standing efforts in the field of opioid analgesics from the class of morphinans led to N-meth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f4ce41cf98ebbf97e8fb030fb5d20ad7
https://pubmed.ncbi.nlm.nih.gov/28125215
https://pubmed.ncbi.nlm.nih.gov/28125215
Publikováno v:
Current Pharmaceutical Design. 19:7362-7372
The κ opioid receptor (KOR) plays a significant role in many physiological functions, including pain relief, stress, depression, drug abuse, anxiety and psychotic behaviors. KORs are widely distributed in the central and peripheral nervous systems,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::43d20c517a4f54dea1dd31d6d731ac5f
https://doi.org/10.2174/138161281942140105162601
https://doi.org/10.2174/138161281942140105162601
Autor:
Stefan M Noha, Daniela Schuster
Publikováno v:
In SilicoDrug Discovery and Design. :80-93
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::55ae9604447a8ea317b66511d3e3951a
https://doi.org/10.4155/ebo.13.145
https://doi.org/10.4155/ebo.13.145
Autor:
Oliver Werz, Stefan M. Noha, Antonella Peduto, Rosanna Filosa, Dagmar Barz, Daniela Schuster, Christina Weinigel, Heidi Traber, Anja M. Schaible, Veronika Temml
Publikováno v:
Biochemical Pharmacology. 86:476-486
Embelin (2,5-dihydroxy-3-undecyl-1,4-benzoquinone) possesses anti-inflammatory and anti-carcinogenic properties in vivo, and these features have been related to interference with multiple targets including XIAPs, NF kappa B, STAT-3, Akt and mTOR. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1cc23e686ec9d67587d38c9a88ac449d
https://doi.org/10.1016/j.bcp.2013.04.015
https://doi.org/10.1016/j.bcp.2013.04.015
Autor:
Stefan M. Noha, Oliver Werz, Daniela Schuster, Gerhard Wolber, Susanne Kuehnl, Judith M. Rollinger, Hermann Stuppner, Anja M. Schaible, Bianca Jazzar
Publikováno v:
Bioorganic & Medicinal Chemistry Letters
Graphical abstract
The release of arachidonic acid, a precursor in the production of prostaglandins and leukotrienes, is achieved by activity of the cytosolic phospholipase A2α (cPLA2α). Signaling mediated by this class of bioactive lipids, wh
The release of arachidonic acid, a precursor in the production of prostaglandins and leukotrienes, is achieved by activity of the cytosolic phospholipase A2α (cPLA2α). Signaling mediated by this class of bioactive lipids, wh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94c9e58b47ce3f9f6332368cf2cc8d2
Pharmacophore-based discovery of FXR agonists. Part I: Model development and experimental validation
Autor:
Hermann Stuppner, Valery N. Bochkov, Judith M. Rollinger, Ulrike Grienke, Patrick Markt, Stefan M. Noha, Daniela Schuster, Gerhard Wolber, Markus Binder, Judit Mihaly-Bison
Publikováno v:
Bioorganic & Medicinal Chemistry
Graphical abstract
The farnesoid X receptor (FXR) is involved in glucose and lipid metabolism regulation, which makes it an attractive target for the metabolic syndrome, dyslipidemia, atherosclerosis, and type 2 diabetes. In order to find novel
The farnesoid X receptor (FXR) is involved in glucose and lipid metabolism regulation, which makes it an attractive target for the metabolic syndrome, dyslipidemia, atherosclerosis, and type 2 diabetes. In order to find novel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45314d07482c6b323c58c1d98b7366c
Autor:
Hermann Stuppner, Gerhard Wolber, Judith M. Rollinger, Daniela Schuster, Julia Bauer, Oliver Werz, Stefan M. Noha, Patrick Markt, Katja Wiechmann, Birgit Waltenberger
Publikováno v:
Journal of Medicinal Chemistry. 54:3163-3174
Microsomal prostaglandin E2 synthase-1 (mPGES-1) catalyzes prostaglandin E2 formation and is considered as a potential anti-inflammatory pharmacological target. To identify novel chemical scaffolds active on this enzyme, two pharmacophore models for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::67501fe64d670b72a9ca269ed712883e
https://doi.org/10.1021/jm101309g
https://doi.org/10.1021/jm101309g