Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Stefan Loverix"'
Autor:
Klaas W. Decoene, Tim Hebbrecht, Jan Gettemans, Smita B. Gunnoo, Willem Vannecke, Ignace Lasters, Mathias Laga, Annemieke Madder, Abhishek Iyer, Stefan Loverix
Publikováno v:
Chemical communications (Cambridge, England). 54(84)
Methodologies to conjugate proteins to property-enhancing entities are highly sought after. We report a remarkably simple strategy for conjugating proteins bearing accessible cysteines to unprotected peptides containing a Cys(Scm) protecting group, w
Autor:
Johan Desmet, Yvonne McGrath, Sophie Thiolloy, Eric Lorent, Pieter Van Vlierberghe, Stefan Loverix, Karen Vandenbroucke, Savvas N. Savvides, Lisa Demoen, Franky Baatz, Sabrina Deroo, Maaike Van Trimpont, Philippe Alard, Paula Henderikx, Ignace Lasters, Klaartje Somers, Tim Pieters, Erwin Pannecoucke, Lindy Reunes, Marnik Vuylsteke
Publikováno v:
'Science Advances ', vol: 7, pages: eabe1682-1-eabe1682-17 (2021)
Science Advances
Science advances 7(13), eabe1682 (2021). doi:10.1126/sciadv.abe1682
SCIENCE ADVANCES
Science Advances
Science advances 7(13), eabe1682 (2021). doi:10.1126/sciadv.abe1682
SCIENCE ADVANCES
Science advances 7(13), eabe1682 (2021). doi:10.1126/sciadv.abe1682
The therapeutic scope of antibody and nonantibody protein scaffolds is still prohibitively limited against intracellular drug targets. Here, we demonstrate that the Alphabody sc
The therapeutic scope of antibody and nonantibody protein scaffolds is still prohibitively limited against intracellular drug targets. Here, we demonstrate that the Alphabody sc
Autor:
Stefan Loverix, Ignace Lasters, Janine Schuurman, Rebecca J. Rose, Aran F. Labrijn, Albert J. R. Heck, Paul W. H. I. Parren, Patrick Van Berkel, Ewald T. J. van den Bremer, Jan G. J. van de Winkel
Publikováno v:
Structure, 19(9), 1274-1282. CELL PRESS
Native mass spectrometry (MS) is a powerful technique for studying noncovalent protein-protein interactions. Here, native MS was employed to examine the noncovalent interactions involved in homodimerization of antibody half molecules (HL) in hinge-de
Autor:
P. Henderikx, Stefan Loverix, S. Thiolloy, S. Deroo, Yvonne McGrath, F. Baatz, Karen Vandenbroucke, J. Desmet, P. Alard, I. Lemmens, Eric Lorent, I. Lasters
Publikováno v:
European Journal of Cancer. 69:S132-S133
Autor:
Ignace Lasters, Stefan Loverix, Jean-Claude Schmit, Nathalie Boutonnet, Nadia Beaupain, Manuel Counson, Jurgen Pletinckx, Els Beirnaert, Aurélie Fischer, Sabrina Deroo, Hans De Haard
Publikováno v:
Molecular Immunology. 45:1366-1373
In this study we constructed two phage libraries displaying non-immunized natural human IgM derived HCDR3 repertoires. One library was structurally constrained by a Gly to Cys substitution at position 104 enabling the formation of a disulfide bridge
Autor:
Karen Vandenbroucke, Savvas N. Savvides, Bart Devreese, Klaartje Somers, Johan Desmet, Yurong Wen, Yehudi Bloch, Paula Henderikx, Thore Hettmann, Stefan Loverix, Kenneth Verstraete, Ignace Lasters, Eric Lorent, Sabrina Deroo
Publikováno v:
Nature Communications
'Nature Communications ', vol: 5, pages: 5237-1-5237-12 (2014)
NATURE COMMUNICATIONS
Nature Communications 5, 5237 (20142014). doi:10.1038/ncomms6237
'Nature Communications ', vol: 5, pages: 5237-1-5237-12 (2014)
NATURE COMMUNICATIONS
Nature Communications 5, 5237 (20142014). doi:10.1038/ncomms6237
Protein scaffolds can provide a promising alternative to antibodies for various biomedical and biotechnological applications, including therapeutics. Here we describe the design and development of the Alphabody, a protein scaffold featuring a single-
Publikováno v:
Nucleic Acids Research
The interplay between aromatic stacking and hydrogen bonding in nucleobases has been investigated via high-level quantum chemical calculations. The experimentally observed stacking arrangement between consecutive bases in DNA and RNA/DNA double helic
Publikováno v:
Chemical Physics Letters. 401:40-46
The influence of π–π interactions on the hydrogen bonding ability of pyrimidine and imidazole stacked with substituted benzenes in the T-shaped, parallel-displaced and parallel-sandwich arrangements is studied at the MP2 level of theory. While th
Publikováno v:
The Journal of Physical Chemistry B. 108:17216-17225
The first step in the reduction of arsenate to arsenite catalyzed by the enzyme arsenate reductase (ArsC) from S. aureus plasmid pI258 involves the nucleophilic attack of a cysteine thiolate (Cys10) on the arsenic atom leading to a covalent sulfur-ar
Publikováno v:
The Journal of Physical Chemistry A. 108:6038-6044
The present work focuses on the influence of aromatic stacking on the ability of an aromatic nitrogen base to accept a hydrogen bond. Substituent effects were studied at the MP2 level for 10 complexes of a substituted benzene stacked with pyridine in