Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Stefan Loverix"'
Autor:
Johan Desmet, Yvonne McGrath, Sophie Thiolloy, Eric Lorent, Pieter Van Vlierberghe, Stefan Loverix, Karen Vandenbroucke, Savvas N. Savvides, Lisa Demoen, Franky Baatz, Sabrina Deroo, Maaike Van Trimpont, Philippe Alard, Paula Henderikx, Ignace Lasters, Klaartje Somers, Tim Pieters, Erwin Pannecoucke, Lindy Reunes, Marnik Vuylsteke
Publikováno v:
'Science Advances ', vol: 7, pages: eabe1682-1-eabe1682-17 (2021)
Science Advances
Science advances 7(13), eabe1682 (2021). doi:10.1126/sciadv.abe1682
SCIENCE ADVANCES
Science Advances
Science advances 7(13), eabe1682 (2021). doi:10.1126/sciadv.abe1682
SCIENCE ADVANCES
Science advances 7(13), eabe1682 (2021). doi:10.1126/sciadv.abe1682
The therapeutic scope of antibody and nonantibody protein scaffolds is still prohibitively limited against intracellular drug targets. Here, we demonstrate that the Alphabody sc
The therapeutic scope of antibody and nonantibody protein scaffolds is still prohibitively limited against intracellular drug targets. Here, we demonstrate that the Alphabody sc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91f1a64aa5091424a4696ff8b839c4dc
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57573
https://epn-library.esrf.fr/flora/jsp/index_view_direct_anonymous.jsp?record=doc:PUB_ESRF:57573
Autor:
Klaas W. Decoene, Tim Hebbrecht, Jan Gettemans, Smita B. Gunnoo, Willem Vannecke, Ignace Lasters, Mathias Laga, Annemieke Madder, Abhishek Iyer, Stefan Loverix
Publikováno v:
Chemical communications (Cambridge, England). 54(84)
Methodologies to conjugate proteins to property-enhancing entities are highly sought after. We report a remarkably simple strategy for conjugating proteins bearing accessible cysteines to unprotected peptides containing a Cys(Scm) protecting group, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f049a7f4710f23d31465127da06066e
https://pubmed.ncbi.nlm.nih.gov/30285017
https://pubmed.ncbi.nlm.nih.gov/30285017
Autor:
Franky Baatz, Stefan Loverix, Yvonne McGrath, Ignace Lasters, Karen Vandenbroucke, Sophie Thiolloy, Sabrina Deroo, Philippe Alard, Paula Henderikx, Johan Desmet, Eric Lorent
Publikováno v:
Cancer Research. 77:28-28
The pro-survival protein Myeloid Cell Leukaemia-1 (Mcl-1) plays an essential role in survival of numerous cancers. MCL-1 gene amplifications occur in a variety of human cancers and overexpression of the Mcl-1 protein is often associated with chemothe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::e47e5f588edac7113d067ba2bb10c042
https://doi.org/10.1158/1538-7445.am2017-28
https://doi.org/10.1158/1538-7445.am2017-28
Autor:
Stefan Loverix, Ignace Lasters, Janine Schuurman, Rebecca J. Rose, Aran F. Labrijn, Albert J. R. Heck, Paul W. H. I. Parren, Patrick Van Berkel, Ewald T. J. van den Bremer, Jan G. J. van de Winkel
Publikováno v:
Structure, 19(9), 1274-1282. CELL PRESS
Native mass spectrometry (MS) is a powerful technique for studying noncovalent protein-protein interactions. Here, native MS was employed to examine the noncovalent interactions involved in homodimerization of antibody half molecules (HL) in hinge-de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7390d4315c6757b314b2afe7723fe31
https://doi.org/10.1016/j.str.2011.06.016
https://doi.org/10.1016/j.str.2011.06.016
Autor:
P. Henderikx, Stefan Loverix, S. Thiolloy, S. Deroo, Yvonne McGrath, F. Baatz, Karen Vandenbroucke, J. Desmet, P. Alard, I. Lemmens, Eric Lorent, I. Lasters
Publikováno v:
European Journal of Cancer. 69:S132-S133
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a107fb7ad7e1e46209ec9effb0b3218
https://doi.org/10.1016/s0959-8049(16)32993-8
https://doi.org/10.1016/s0959-8049(16)32993-8
Autor:
Ignace Lasters, Stefan Loverix, Jean-Claude Schmit, Nathalie Boutonnet, Nadia Beaupain, Manuel Counson, Jurgen Pletinckx, Els Beirnaert, Aurélie Fischer, Sabrina Deroo, Hans De Haard
Publikováno v:
Molecular Immunology. 45:1366-1373
In this study we constructed two phage libraries displaying non-immunized natural human IgM derived HCDR3 repertoires. One library was structurally constrained by a Gly to Cys substitution at position 104 enabling the formation of a disulfide bridge
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6236f7b692a79ab18070ecd88149edad
https://doi.org/10.1016/j.molimm.2007.09.001
https://doi.org/10.1016/j.molimm.2007.09.001
Autor:
Philippe Alard, Paula Henderikx, Karen Vandenbroucke, Ignace Lasters, Irma Lemmens, Franky Baatz, Johan Desmet, Sabrina Deroo, Eric Lorent, Stefan Loverix, Yvonne McGrath, Sophie Thiolloy
Publikováno v:
Cancer Research. 76:3850-3850
We have developed Cell Penetrating Alphabodies (CPABs), a novel and unique therapeutic class of proteins engineered to efficiently enter cells. In vitro, uptake in a range of tumor and non-tumor cell types occurs rapidly with cytosol levels of up to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71b941e9c3a83449d94d0370e4f789d7
https://doi.org/10.1158/1538-7445.am2016-3850
https://doi.org/10.1158/1538-7445.am2016-3850
Publikováno v:
Nucleic Acids Research
The interplay between aromatic stacking and hydrogen bonding in nucleobases has been investigated via high-level quantum chemical calculations. The experimentally observed stacking arrangement between consecutive bases in DNA and RNA/DNA double helic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd97bf471d40ceec5aa1fd02ca8bcaa
https://doi.org/10.1093/nar/gki317
https://doi.org/10.1093/nar/gki317
Publikováno v:
Chemical Physics Letters. 401:40-46
The influence of π–π interactions on the hydrogen bonding ability of pyrimidine and imidazole stacked with substituted benzenes in the T-shaped, parallel-displaced and parallel-sandwich arrangements is studied at the MP2 level of theory. While th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6244fea95a6455da4684a17cd000356
https://doi.org/10.1016/j.cplett.2004.11.016
https://doi.org/10.1016/j.cplett.2004.11.016
Publikováno v:
The Journal of Physical Chemistry B. 108:17216-17225
The first step in the reduction of arsenate to arsenite catalyzed by the enzyme arsenate reductase (ArsC) from S. aureus plasmid pI258 involves the nucleophilic attack of a cysteine thiolate (Cys10) on the arsenic atom leading to a covalent sulfur-ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34da159a65a750528101742a4eaa637e
https://doi.org/10.1021/jp0486550
https://doi.org/10.1021/jp0486550