Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Stefan Lohmer"'
Autor:
Barbara Peixoto Pinheiro, Marcus Müller, Michael Bös, Jamil Guezguez, Michael Burnet, Mara Tornincasa, Riccardo Rizzetto, Jean-Francois Rolland, Chiara Liberati, Stefan Lohmer, Youssef Adel, Hubert Löwenheim
Publikováno v:
Cell Death and Disease, Vol 13, Iss 7, Pp 1-9 (2022)
Abstract Age-related hearing loss (ARHL) is the most common sensory impairment mainly caused by degeneration of sensory hair cells in the cochlea with no causal medical treatment available. Auditory function and sensory hair cell survival critically
Externí odkaz:
https://doaj.org/article/6df236bb96ca4bfbb0341e5a01aabb2b
Autor:
Silvia Cainarca, Simone Fenu, Cinzia Ferri, Cinzia Nucci, Patrizia Arioli, Andrea Menegon, Lorenzo Piemonti, Stefan Lohmer, Lawrence Wrabetz, Sabrina Corazza
Publikováno v:
PLoS ONE, Vol 5, Iss 1, p e8882 (2010)
Exogenous expression of pharmacological targets in transformed cell lines has been the traditional platform for high throughput screening of small molecules. However, exogenous expression in these cells is limited by aberrant dosage, or its toxicity,
Externí odkaz:
https://doaj.org/article/537db1fbbfe2407e801923714b5d0056
Publikováno v:
SLAS discovery : advancing life sciences RD. 23(1)
The lack of miniaturized and cost-effective methods to control cellular excitability with dosable and temporally precise electrical perturbations represents a long-lasting and unsolved bottleneck for ion channel drug discovery pipelines. Here we deve
Autor:
Sophie Veitinger, Agnes Weth, Daniela Fluegge, Lisa M. Moeller, Eva M. Neuhaus, Silvia Cainarca, Sabrina Corazza, Werner Baumgartner, Jennifer Spehr, Stefan Lohmer, Marc Spehr, Annika Cichy, Monika Gorin
Publikováno v:
Nature Neuroscience. 15:754-762
In olfactory sensory neurons (OSNs), cytosolic Ca(2+) controls the gain and sensitivity of olfactory signaling. Important components of the molecular machinery that orchestrates OSN Ca(2+) dynamics have been described, but key details are still missi
Autor:
Thomas Veitinger, Corinna H. Engelhardt, Daniela Fluegge, Sophie Veitinger, Sabrina Corazza, Silvia Cainarca, Jennifer Spehr, Hanns Hatt, Stefan Lohmer, Marc Spehr, Eva M. Neuhaus
Publikováno v:
The Journal of Physiology. 589:5033-5055
Non-Technical Summary In mammalian testes, Sertoli cells play a key physiological role in germ cell development. Previous research has implicated local ATP release as a potential mechanism of Sertoli cell stimulation. We show that, in mouse Sertoli c
Autor:
Silvia Cainarca, Sabrina Corazza, Silvia Bovolenta, Simone Fenu, Andrea Menegon, Patrizia Arioli, Stefan Lohmer
Publikováno v:
SLAS Discovery. 15:1132-1143
The use of engineered mouse embryonic stem (mES) cells in high-throughput screening (HTS) can offer new opportunities for studying complex targets in their native environment, increasing the probability of discovering more meaningful hits. The author
Publikováno v:
SLAS Discovery. 12:694-704
The present work describes the engineering and characterization of a new Ca(2+)-activated photoprotein (Photina) and its use in mammalian cell lines for implementation of flash luminescence cell-based assays for high-throughput screening (HTS). When
Autor:
Katharina Montag, Anna Mondini, Viviana Agus, Alberto di Silvio, Jean Francois Rolland, Lia Scarabottolo, Stefan Lohmer, Sara Tremolada, Loredana Redaelli
Publikováno v:
SPIE Proceedings.
The use of light-activated proteins represents a powerful tool to control biological processes with high spatial and temporal precision. These so called “optogenetic” technologies have been successfully validated in many recombinant systems, and
Publikováno v:
ASSAY and Drug Development Technologies. 4:165-173
Guanylate cyclase (GC) catalyzes the biosynthesis of cyclic guanosine 3',5'- monophosphate (cGMP) from GTP. GC exists in two isoenzyme forms: soluble and membrane-bound. The soluble GC (sGC) is a heterodimer composed of an alpha and a beta subunit, a
Publikováno v:
The Plant Cell. 5:65-73
The protein encoded by the Opaque-2 (O2) gene is a transcription factor, translated from an mRNA that possesses an unusually long 5' leader sequence containing three upstream open reading frames (uORFs). The efficiency of translation of O2 mRNA has b