Zobrazeno 1 - 10
of 58
pro vyhledávání: '"Stefan Legewie"'
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-22 (2023)
Abstract Alternative splicing is an important step in eukaryotic mRNA pre-processing which increases the complexity of gene expression programs, but is frequently altered in disease. Previous work on the regulation of alternative splicing has demonst
Externí odkaz:
https://doaj.org/article/f332eef2470844c2acd8d93080bbe0f4
Autor:
Mariela Cortés-López, Laura Schulz, Mihaela Enculescu, Claudia Paret, Bea Spiekermann, Mathieu Quesnel-Vallières, Manuel Torres-Diz, Sebastian Unic, Anke Busch, Anna Orekhova, Monika Kuban, Mikhail Mesitov, Miriam M. Mulorz, Rawan Shraim, Fridolin Kielisch, Jörg Faber, Yoseph Barash, Andrei Thomas-Tikhonenko, Kathi Zarnack, Stefan Legewie, Julian König
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
Multiple alternative splicing events in CD19 mRNA have been associated with resistance/relapse to CD19 CAR-T therapy in patients with B cell malignancies. Here, by combining patient data and a high-throughput mutagenesis screen, the authors identify
Externí odkaz:
https://doaj.org/article/c08d347a8dc943b8ab905da6ad76b36d
Autor:
Niklas Kolbe, Lorenz Hexemer, Lukas-Malte Bammert, Alexander Loewer, Mária Lukáčová-Medvid'ová, Stefan Legewie
Publikováno v:
PLoS Computational Biology, Vol 18, Iss 6, p e1010266 (2022)
Cells sense their surrounding by employing intracellular signaling pathways that transmit hormonal signals from the cell membrane to the nucleus. TGF-β/SMAD signaling encodes various cell fates, controls tissue homeostasis and is deregulated in dise
Externí odkaz:
https://doaj.org/article/3bb50be3c3134aec800dc9093ba0e88b
Autor:
Kolja Becker, Alina Bluhm, Nuria Casas-Vila, Nadja Dinges, Mario Dejung, Sergi Sayols, Clemens Kreutz, Jean-Yves Roignant, Falk Butter, Stefan Legewie
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Proteome and transcriptome often show poor correlation, hindering the system-wide analysis of post-transcriptional regulation. Here, the authors study proteome and transcriptome dynamics during Drosophila embryogenesis and present basic mathematical
Externí odkaz:
https://doaj.org/article/90b8c01a01c74981a5040868dc210ebe
Autor:
Simon Braun, Mihaela Enculescu, Samarth T. Setty, Mariela Cortés-López, Bernardo P. de Almeida, F. X. Reymond Sutandy, Laura Schulz, Anke Busch, Markus Seiler, Stefanie Ebersberger, Nuno L. Barbosa-Morais, Stefan Legewie, Julian König, Kathi Zarnack
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-18 (2018)
Alternative splicing is a critical step in eukaryotic gene expression but its molecular rules are not fully understood. Here, the authors develop a high-throughput mutagenesis approach to comprehensively characterise determinants of alternative splic
Externí odkaz:
https://doaj.org/article/e09001a3cedf4849a519718409e93dcf
Autor:
Stefan M Kallenberger, Anne L Unger, Stefan Legewie, Konstantinos Lymperopoulos, Ursula Klingmüller, Roland Eils, Dirk-Peter Herten
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 9, p e1005779 (2017)
Cells typically vary in their response to extracellular ligands. Receptor transport processes modulate ligand-receptor induced signal transduction and impact the variability in cellular responses. Here, we quantitatively characterized cellular variab
Externí odkaz:
https://doaj.org/article/28034bad7c104276a1b6160440423a0b
Autor:
Mihaela Enculescu, Christoph Metzendorf, Richard Sparla, Maximilian Hahnel, Johannes Bode, Martina U Muckenthaler, Stefan Legewie
Publikováno v:
PLoS Computational Biology, Vol 13, Iss 1, p e1005322 (2017)
Systemic iron levels must be maintained in physiological concentrations to prevent diseases associated with iron deficiency or iron overload. A key role in this process plays ferroportin, the only known mammalian transmembrane iron exporter, which re
Externí odkaz:
https://doaj.org/article/9cbcb652b269424cad432e7491897bbd
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 1, p e1003421 (2014)
Systemic iron homeostasis involves a negative feedback circuit in which the expression level of the peptide hormone hepcidin depends on and controls the iron blood levels. Hepcidin expression is regulated by the BMP6/SMAD and IL6/STAT signaling casca
Externí odkaz:
https://doaj.org/article/01d4fa0c77d1458d927b551e10bdb096
Publikováno v:
PLoS ONE, Vol 8, Iss 12 (2013)
Externí odkaz:
https://doaj.org/article/2650ae4cea24458dab36dfd2afd78975
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 12, p e1003357 (2013)
Cells reliably sense environmental changes despite internal and external fluctuations, but the mechanisms underlying robustness remain unclear. We analyzed how fluctuations in signaling protein concentrations give rise to cell-to-cell variability in
Externí odkaz:
https://doaj.org/article/73bf2dc12bab41efaadee6287f6d1428