Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Stefan Lanker"'
Autor:
Jiwon Oh, Laura Airas, Daniel Harrison, Elina Järvinen, Terrie Livingston, Stefan Lanker, Rayaz A. Malik, Darin T. Okuda, Pablo Villoslada, Helga E. de Vries
Publikováno v:
Frontiers in Neurology, Vol 14 (2023)
Key unmet needs in multiple sclerosis (MS) include detection of early pathology, disability worsening independent of relapses, and accurate monitoring of treatment response. Collaborative approaches to address these unmet needs have been driven in pa
Externí odkaz:
https://doaj.org/article/87221791cd044fc7bb3d3ea96d8fff84
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70954 (2013)
Natalizumab inhibits the transmigration of activated T lymphocytes into the brain and is highly efficacious in multiple sclerosis (MS). However, from a pharmacogenomic perspective, its efficacy and safety in specific patients remain unclear. Here our
Externí odkaz:
https://doaj.org/article/33da09d155ec4c5d94663473815111fd
Autor:
Janna La Rue, Stefan Lanker, Keiko Nakayama, Kevin M. Friedman, Catherine Berset, Dong-Er Zhang, Sara A. Tokarz, Keiichi I. Nakayama
Publikováno v:
Journal of Biological Chemistry. 279:46424-46430
The Skp2 oncoprotein belongs to the family of F-box proteins that function as substrate recognition factors for SCF (Skp1, cullin, F-box protein) E3 ubiquitin-ligase complexes. Binding of the substrate to the SCFSkp2 complex catalyzes the conjugation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70fa8d10967bbe8c673ba0adf2b5a922
https://doi.org/10.1074/jbc.m403189200
https://doi.org/10.1074/jbc.m403189200
Publikováno v:
Molecular and Cellular Biology. 22:4463-4476
Degradation of Saccharomyces cerevisiae G(1) cyclins Cln1 and Cln2 is mediated by the ubiquitin-proteasome pathway and involves the SCF E3 ubiquitin-ligase complex containing the F-box protein Grr1 (SCF(Grr1)). Here we identify the domain of Cln2 tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdcc1d05142f68feec6651c2d8b9f875
https://doi.org/10.1128/mcb.22.13.4463-4476.2002
https://doi.org/10.1128/mcb.22.13.4463-4476.2002
Autor:
Curt Wittenberg, E.Elizabeth Patton, Stefan Lanker, Brandt L. Schneider, Bruce Futcher, Mike Tyers, Michael D. Mendenhall
Publikováno v:
Nature. 395:86-89
In most eukaryotes, commitment to cell division occurs in late G1 phase at an event called Start in the yeast Saccharomyces cerevisiae, and called the restriction point in mammalian cells. Start is triggered by the cyclin-dependent kinase Cdc28 and t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39f2a5eac371dcf9c17e69881f6cd391
https://doi.org/10.1038/25774
https://doi.org/10.1038/25774
Autor:
Ghazal Banisadr, Joseph R. Podojil, Stefan Lanker, Linda A. Piccinini, Stephen D. Miller, Samantha R. Schwartz, Richard J. Miller
Publikováno v:
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology. 9(3)
Excessive infiltration of leukocytes and the elaboration of inflammatory cytokines are believed to be responsible for the observed damage to neurons and oligodendrocytes during multiple sclerosis (MS). Blocking adhesion molecules or preventing the ef
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d02685296b44e1fa258eff2e8fc4aee
https://pubmed.ncbi.nlm.nih.gov/25159059
https://pubmed.ncbi.nlm.nih.gov/25159059
Publikováno v:
Science. 271:1597-1601
Cyclins regulate the major cell cycle transitions in eukaryotes through association with cyclin-dependent protein kinases (CDKs). In yeast, G1 cyclins are essential, rate-limiting activators of cell cycle initiation. G1-specific accumulation of one G
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619b84f38e4f4287d61947af43bce1fa
https://doi.org/10.1126/science.271.5255.1597
https://doi.org/10.1126/science.271.5255.1597
Publikováno v:
Cell. 70:647-657
We cloned the GCD5 gene of S. cerevisiae and found it to be identical to KRS1 , which encodes lysyl-tRNA synthetase (LysRS). The mutation gcd5-1 changes a conserved residue in the putative lysine-binding domain of LysRS. This leads to a defect in lys
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f8e5e8fbb1ad8f83916179178edc78b
https://doi.org/10.1016/0092-8674(92)90433-d
https://doi.org/10.1016/0092-8674(92)90433-d
Autor:
Halina Offner, Susan Goelz, Arthur A. Vandenbark, Jianya Huan, Stefan Lanker, Dorian La Tocha, Marisa Agotsch, Dennis Bourdette
Publikováno v:
Journal of neuroimmunology. 215(1-2)
Disease modifying effects of interferon (IFN)-beta therapy in patients with multiple sclerosis (MS) may be mediated in part through enhanced immunoregulation by the CD56(bright) subpopulation of natural killer (NK) cells and by Foxp3+ (not italicized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b6c29fe1e08a7893f5354dc90f9ad0f
https://pubmed.ncbi.nlm.nih.gov/19758707
https://pubmed.ncbi.nlm.nih.gov/19758707
Autor:
Stefan Lanker, Julien P. Fey
Publikováno v:
Yeast (Chichester, England). 24(5)
The ability to integrate nutrient availability into cell cycle regulation is critical for the viability of organisms. The Saccharomyces cerevisiae ubiquitin ligase SCF(Grr1) regulates the stability of several proteins that participate in cell divisio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee7ce25a0d85423f92eda464d4c65b01
https://pubmed.ncbi.nlm.nih.gov/17366522
https://pubmed.ncbi.nlm.nih.gov/17366522