Structural and functional analysis of aquaporin-2 mutants involved in nephrogenic diabetes insipidus

Autor: Carl Johan Hagströmer, Jonas Hyld Steffen, Stefan Kreida, Tamim Al-Jubair, Anna Frick, Pontus Gourdon, Susanna Törnroth-Horsefield

Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-15 (2023)

Abstract Aquaporins are water channels found in the cell membrane, where they allow the passage of water molecules in and out of the cells. In the kidney collecting duct, arginine vasopressin-dependent trafficking of aquaporin-2 (AQP2) fine-tunes rea

Externí odkaz: https://doaj.org/article/e8396a28c8e042f783b0a842ff88dc15

Cryo-EM structure of the Agrobacterium tumefaciens T4SS-associated T-pilus reveals stoichiometric protein-phospholipid assembly

Autor: Stefan Kreida, Akihiro Narita, Matthew D. Johnson, Elitza I. Tocheva, Anath Das, Debnath Ghosal, Grant J. Jensen

Agrobacterium tumefaciens causes crown gall disease in plants by the horizontal transfer of oncogenic DNA. The conjugation is mediated by the VirB/D4 type 4 secretion system (T4SS) that assembles an extracellular filament, the T-pilus, and is involve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1469bf7a23de6b67f9cba9847ac17f22
https://resolver.caltech.edu/CaltechAUTHORS:20230323-670848000.1

Dynamic structural adaptations enable the endobiotic predation ofbdellovibrio bacteriovorus

Autor: Mohammed Kaplan, Yi-Wei Chang, Catherine M. Oikonomou, William J. Nicolas, Andrew I. Jewett, Stefan Kreida, Przemysław Dutka, Lee A. Rettberg, Stefano Maggi, Grant J. Jensen

Bdellovibrio bacteriovorusis an endobiotic microbial predator that offers promise as a living antibiotic for its ability to kill Gram-negative bacteria, including human pathogens. Even after six decades of study, fundamental details of its predation

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c7bf428eceaf18d925e168d688b09ed
https://doi.org/10.1101/2022.06.13.496000

Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema

Autor: Charlotte Clarke-Bland, Andrea M. Halsey, Hiroaki Ishida, Matthew T. Conner, Alex C. Conner, Philip Kitchen, Ann Logan, Susanna Törnroth-Horsefield, Julie Winkel Missel, Mootaz M. Salman, Pontus Gourdon, Sharif Almutiri, Stefan Kreida, Hans J. Vogel, Zubair Ahmed, Roslyn M. Bill, Tamim Al-Jubair, Justin A. MacDonald

Publikováno v: Kitchen, P, Salman, M M, Halsey, A M, Clarke-Bland, C, MacDonald, J A, Ishida, H, Vogel, H J, Almutiri, S, Logan, A, Kreida, S, Al-Jubair, T, Winkel Missel, J, Gourdon, P, Törnroth-Horsefield, S, Conner, M T, Ahmed, Z, Conner, A C & Bill, R M 2020, ' Targeting Aquaporin-4 Subcellular Localization to Treat Central Nervous System Edema ', Cell, vol. 181, no. 4, pp. 784-799 . https://doi.org/10.1016/j.cell.2020.03.037
Cell

Summary Swelling of the brain or spinal cord (CNS edema) affects millions of people every year. All potential pharmacological interventions have failed in clinical trials, meaning that symptom management is the only treatment option. The water channe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c988cdd7f5d6e5a62e364529ce9b2792
https://curis.ku.dk/ws/files/244572535/OA_Targeting_Aquaporin_4_Subcellular_Localization_to_Treat_Central_Nervous_System_Edema.pdf

On-chip crystallization for serial crystallography experiments and on-chip ligand-binding studies

Autor: Julia, Lieske, Maximilian, Cerv, Stefan, Kreida, Dana, Komadina, Janine, Fischer, Miriam, Barthelmess, Pontus, Fischer, Tim, Pakendorf, Oleksandr, Yefanov, Valerio, Mariani, Thomas, Seine, Breyan H, Ross, Eva, Crosas, Olga, Lorbeer, Anja, Burkhardt, Thomas J, Lane, Sebastian, Guenther, Julian, Bergtholdt, Silvan, Schoen, Susanna, Törnroth-Horsefield, Henry N, Chapman, Alke, Meents

Publikováno v: IUCrJ
IUCrJ, Vol 6, Iss 4, Pp 714-728 (2019)

Direct protein crystallization on fixed-target sample holders allows highly efficient serial crystallography experiments and ligand-binding studies.
Efficient and reliable sample delivery has remained one of the bottlenecks for serial crystallog

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::061af78f91f87763c5bba2b7df2d5a59
https://hdl.handle.net/21.11116/0000-0004-81C2-E21.11116/0000-0004-81C4-C