Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Stefan Krautwald"'
Publikováno v:
Signal Transduction and Targeted Therapy, Vol 8, Iss 1, Pp 1-2 (2023)
Externí odkaz:
https://doaj.org/article/1801e1340cb746568f10efac7d34bf0f
Autor:
Friedrich Alexander von Samson-Himmelstjerna, Benedikt Kolbrink, Theresa Riebeling, Ulrich Kunzendorf, Stefan Krautwald
Publikováno v:
Cells, Vol 11, Iss 14, p 2134 (2022)
Ten years after its initial description, ferroptosis has emerged as the most intensely studied entity among the non-apoptotic forms of regulated cell death. The molecular features of ferroptotic cell death and its functional role have been characteri
Externí odkaz:
https://doaj.org/article/9da857f7905f4d5e90fd4116e043263d
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 8 (2020)
Necroptosis and pyroptosis are two forms of regulated cell death. They are executed by the proteins mixed-lineage kinase domain-like (MLKL) and gasdermin D (GSDMD), respectively. Once activated by numerous pathways, these proteins form membrane pores
Externí odkaz:
https://doaj.org/article/5e075319156c4ad7bcb954cd7bf681a0
Autor:
Nina Van Opdenbosch, Hanne Van Gorp, Maarten Verdonckt, Pedro H.V. Saavedra, Nathalia M. de Vasconcelos, Amanda Gonçalves, Lieselotte Vande Walle, Dieter Demon, Magdalena Matusiak, Filip Van Hauwermeiren, Jinke D’Hont, Tino Hochepied, Stefan Krautwald, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
Publikováno v:
Cell Reports, Vol 21, Iss 12, Pp 3427-3444 (2017)
Summary: The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC. Here, we show that NLRP1b and NLRC4 trigger caspase-8-mediate
Externí odkaz:
https://doaj.org/article/a03de55f3cff4bf0b903b77a4609b2e2
Autor:
Uris Ros, Aida Peña-Blanco, Kay Hänggi, Ulrich Kunzendorf, Stefan Krautwald, W. Wei-Lynn Wong, Ana J. García-Sáez
Publikováno v:
Cell Reports, Vol 19, Iss 1, Pp 175-187 (2017)
Necroptosis is a form of regulated necrosis that results in cell death and content release after plasma membrane permeabilization. However, little is known about the molecular events responsible for the disruption of the plasma membrane. Here, we fin
Externí odkaz:
https://doaj.org/article/f772884ba0c946f4a0b83a88032db294
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Necroptosis, initially identified as a backup cell death program when apoptosis is hindered, is a prominent feature in the etiology and progression of many human diseases, such as ischemic injury and sepsis. Receptor-interacting protein kinase 3 (RIP
Externí odkaz:
https://doaj.org/article/97ae79635e7a4329b45a2eb32bc47d80
Autor:
Jérémie Gautheron, Mihael Vucur, Anne T. Schneider, Ilenia Severi, Christoph Roderburg, Sanchari Roy, Matthias Bartneck, Peter Schrammen, Mauricio Berriel Diaz, Josef Ehling, Felix Gremse, Felix Heymann, Christiane Koppe, Twan Lammers, Fabian Kiessling, Niels Van Best, Oliver Pabst, Gilles Courtois, Andreas Linkermann, Stefan Krautwald, Ulf P. Neumann, Frank Tacke, Christian Trautwein, Douglas R. Green, Thomas Longerich, Norbert Frey, Mark Luedde, Matthias Bluher, Stephan Herzig, Mathias Heikenwalder, Tom Luedde
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-16 (2016)
The kinase RIPK3 initiates necroptosis, which has been reported to promote inflammation in various pathological conditions. Here, the authors show that genetic ablation of Ripk3results in adipocyte apoptosis and white adipose tissue inflammation in o
Externí odkaz:
https://doaj.org/article/5ab7094df7b24c7e834e933314f7ba85
Autor:
Shrikant R. Mulay, Jyaysi Desai, Santhosh V. Kumar, Jonathan N. Eberhard, Dana Thomasova, Simone Romoli, Melissa Grigorescu, Onkar P. Kulkarni, Bastian Popper, Volker Vielhauer, Gabriele Zuchtriegel, Christoph Reichel, Jan Hinrich Bräsen, Paola Romagnani, Rostyslav Bilyy, Luis E. Munoz, Martin Herrmann, Helen Liapis, Stefan Krautwald, Andreas Linkermann, Hans-Joachim Anders
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Kidney stone disease is caused by accumulation of oxalate crystals, which trigger tissue injury, inflammation and cell death. Mulay et al. show that crystals induce cell death in the kidney through necroptosis, and propose that this pathway may be a
Externí odkaz:
https://doaj.org/article/4a9913da2de547b6b63c6e14c5eae1e2
Autor:
Stephen W.G. Tait, Andrew Oberst, Giovanni Quarato, Sandra Milasta, Martina Haller, Ruoning Wang, Maria Karvela, Gabriel Ichim, Nader Yatim, Matthew L. Albert, Grahame Kidd, Randall Wakefield, Sharon Frase, Stefan Krautwald, Andreas Linkermann, Douglas R. Green
Publikováno v:
Cell Reports, Vol 5, Iss 4, Pp 878-885 (2013)
Programmed necrosis (or necroptosis) is a form of cell death triggered by the activation of receptor interacting protein kinase-3 (RIPK3). Several reports have implicated mitochondria and mitochondrial reactive oxygen species (ROS) generation as effe
Externí odkaz:
https://doaj.org/article/3bac1bef9e604f5e88b84218c1ad4f99
Publikováno v:
Biochemical Society Transactions. 50:1197-1205
The RIP homotypic interaction motif (RHIM) is a conserved protein domain that is approximately 18–22 amino acids in length. In humans, four proteins carrying RHIM domains have been identified: receptor-interacting serine/threonine protein kinase (R