Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Stefan Koep"'
Publikováno v:
Journal of Computer-Aided Molecular Design. 35:505-516
Selective progesterone receptor modulators are promising therapeutic options for the treatment of uterine fibroids. Vilaprisan, a new chemical entity that was discovered at Bayer is currently in clinical development. In this study we provide a combin
Autor:
Gadamsetti S. Babu, Hans-Joachim Gais, Gerhard Raabe, Markus Günter, Shashi Kant Tiwari, Andreas Lindenmaier, Vijaya Bhaskara Reddy Iska, Stefan Koep, Leleti Rajender Reddy, Franz Köhler
Publikováno v:
Journal of the American Chemical Society. 128:7360-7373
Methylation of the enantiopure functionalized vinyl sulfoximines 5a-e and 14a-d followed by a F- ion or DBU-mediated isomerization of the vinyl aminosulfoxonium salts 7a-e and 15a-d, respectively, gave the allyl aminosulfoxonium salts 10a-e and 17a-d
Publikováno v:
Journal of the American Chemical Society. 125:13243-13251
Described is an asymmetric synthesis of new Delta(3a,4)-unsaturated, fused bicyclic proline analogues from cyclic bis(allylsulfoximine)titanium complexes and N-tert-butylsulfonyl imino ethyl ester. Treatment of the enantiomerically pure five-, six-,
Publikováno v:
Journal of the American Chemical Society. 124:7789-7800
Selective addition of the chiral, sulfonimidoyl substituted bis(allyl)titanium complexes 5a-d, which are configurationally labile in regard to the Calpha-atoms, to N-toluenesulfonyl (Ts)-, N-2-trimethylsilylethanesulfonyl (SES)-, and N-tert-butylsulf
Publikováno v:
Synthesis. :967-969
Synthesis of (2-methyl-propane-2-sulfonylimino) acetic acid ethyl ester from tert-butylsulfonamide, thionyl chloride and ethyl glyoxylate is described. The N-tert-butylsulfonyl imino ester has served as a substitute of the corresponding N-toluenesulf
Publikováno v:
ChemInform. 36
An asymmetric synthesis of the 3-substituted Δ 3,4 -unsaturated prolines 7a – e and 3-substituted 4-methylene prolines 14a – c starting from the corresponding γ,δ-unsaturated α-amino acids 4a – e and 11a – c , respectively, is described.