Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Stefan Klingler"'
Autor:
Christy Li, Stefan Klingler, Sahra Bodo, Jin Cheng, Yan Pan, Mohammed Adileh, Maria Laura Martin, John Fuller, Regina Feldman, Adam Michel, Zhigang Zhang, Zvi Fuks, Richard Kolesnick
Publikováno v:
Cellular Physiology and Biochemistry, Vol 56, Iss 4, Pp 436-448 (2022)
Externí odkaz:
https://doaj.org/article/016b9a1235f543ed8b0a9269c1f64cec
Autor:
Stefan Klingler, Kuo-Shun Hsu, Guoqiang Hua, Maria Laura Martin, Mohammad Adileh, Timour Baslan, Zhigang Zhang, Philip B. Paty, Zvi Fuks, Anthony M.C. Brown, Richard Kolesnick
Publikováno v:
JCI Insight, Vol 7, Iss 5 (2022)
Recent data establish a logarithmic expansion of leucine rich repeat containing G protein coupled receptor 5–positive (Lgr5+) colonic epithelial stem cells (CESCs) in human colorectal cancer (CRC). Complementary studies using the murine 2-stage azo
Externí odkaz:
https://doaj.org/article/9ef3f2bee094401588a41ba8a913fa23
Publikováno v:
Cancers, Vol 14, Iss 21, p 5416 (2022)
Functional studies of primary cancer have been limited to animal models for a long time making it difficult to study aspects specific to human cancer biology. The development of organoid technology enabled us to culture human healthy and tumor cells
Externí odkaz:
https://doaj.org/article/0deb9c8a6269499c94193ee6f555ccb4
Autor:
Dinesh K. Singh, Rahul K. Kollipara, Vamsidara Vemireddy, Xiao-Li Yang, Yuxiao Sun, Nanda Regmi, Stefan Klingler, Kimmo J. Hatanpaa, Jack Raisanen, Steve K. Cho, Shyam Sirasanagandla, Suraj Nannepaga, Sara Piccirillo, Tomoyuki Mashimo, Shan Wang, Caroline G. Humphries, Bruce Mickey, Elizabeth A. Maher, Hongwu Zheng, Ryung S. Kim, Ralf Kittler, Robert M. Bachoo
Publikováno v:
Cell Reports, Vol 18, Iss 4, Pp 961-976 (2017)
Efforts to identify and target glioblastoma (GBM) drivers have primarily focused on receptor tyrosine kinases (RTKs). Clinical benefits, however, have been elusive. Here, we identify an SRY-related box 2 (SOX2) transcriptional regulatory network that
Externí odkaz:
https://doaj.org/article/584c70e23319436aa0e06b23b2f7fe46
Autor:
Kuo-Shun Hsu, Mohammad Adileh, Maria Laura Martin, Vladimir Makarov, Jiapeng Chen, Chao Wu, Sahra Bodo, Stefan Klingler, Charles-Etienne Gabriel Sauvé, Bryan C. Szeglin, J. Joshua Smith, Zvi Fuks, Nadeem Riaz, Timothy A. Chan, Makoto Nishimura, Philip B. Paty, Richard Kolesnick
Publikováno v:
Cancer Res
Identifying colorectal cancer patient populations responsive to chemotherapy or chemoradiation therapy before surgery remains a challenge. Recently validated mouse protocols for organoid irradiation employ the single hit multi-target (SHMT) algorithm
Autor:
Richard Kolesnick, Philip B. Paty, Makoto Nishimura, Timothy A. Chan, Nadeem Riaz, Zvi Fuks, J. Joshua Smith, Bryan C. Szeglin, Charles-Etienne Gabriel Sauvé, Stefan Klingler, Sahra Bodo, Chao Wu, Jiapeng Chen, Vladimir Makarov, Maria Laura Martin, Mohammad Adileh, Kuo-Shun Hsu
Identifying colorectal cancer patient populations responsive to chemotherapy or chemoradiation therapy before surgery remains a challenge. Recently validated mouse protocols for organoid irradiation employ the single hit multi-target (SHMT) algorithm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b5f89297d7a7036ad8f69d84c8e127f
https://doi.org/10.1158/0008-5472.c.6513871.v1
https://doi.org/10.1158/0008-5472.c.6513871.v1
Autor:
Richard N. Kolesnick, Philip B. Paty, Zvi Fuks, Joseph O. Deasy, Adriana Haimovitz-Friedman, Stefan Klingler, Sahra Bodo, Jimmy A. Rotolo, John D. Fuller, Christy Li, Sang Gyu Lee, Guoqiang Hua, Kuo-Shun Hsu, Mohammad Adileh, Maria Laura Martin
Tissue survival responses to ionizing radiation are nonlinear with dose, rather yielding tissue-specific descending curves that impede straightforward analysis of biologic effects. Apoptotic cell death often occurs at low doses, while at clinically r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b90da75d2b8064d6fd738fd80c5b6e0d
https://doi.org/10.1158/0008-5472.c.6511909
https://doi.org/10.1158/0008-5472.c.6511909
Autor:
Richard Kolesnick, Philip B. Paty, Makoto Nishimura, Timothy A. Chan, Nadeem Riaz, Zvi Fuks, J. Joshua Smith, Bryan C. Szeglin, Charles-Etienne Gabriel Sauvé, Stefan Klingler, Sahra Bodo, Chao Wu, Jiapeng Chen, Vladimir Makarov, Maria Laura Martin, Mohammad Adileh, Kuo-Shun Hsu
Supplementary Data from Colorectal Cancer Develops Inherent Radiosensitivity That Can Be Predicted Using Patient-Derived Organoids
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89f56bf6bd6553d4ad10d524b2c10a0a
https://doi.org/10.1158/0008-5472.22431316.v1
https://doi.org/10.1158/0008-5472.22431316.v1
Autor:
Richard N. Kolesnick, Philip B. Paty, Zvi Fuks, Joseph O. Deasy, Adriana Haimovitz-Friedman, Stefan Klingler, Sahra Bodo, Jimmy A. Rotolo, John D. Fuller, Christy Li, Sang Gyu Lee, Guoqiang Hua, Kuo-Shun Hsu, Mohammad Adileh, Maria Laura Martin
Supplementary Materials. Table S1. List of all reagents used in this study; Figure S1. LI organoids regrow after radiation; Figure S2. Sorting strategy for intestinal stem cells from the small and large intestines; Figure S3. Flow cytometry analysis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0863271f610ee64d65aa1d80496b1ff8
https://doi.org/10.1158/0008-5472.22424953.v1
https://doi.org/10.1158/0008-5472.22424953.v1
Autor:
Fritz Aberger, Maria Sibilia, Richard Moriggl, Renate Kroismayr, Gerhard Regl, Cornelia Hauser-Kronberger, Maria Kasper, Doris Mangelberger, Stefan Klingler, Markus Eberl, Harald Schnidar
Persistent activation of the Hedgehog (HH)/GLI signaling pathway has been implicated in the development of a number of human cancers. The GLI zinc finger transcription factors act at the end of the HH signaling cascade to control gene expression, and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::18ac370e3152d7a250e450880eaaa05b
https://doi.org/10.1158/0008-5472.c.6499713.v1
https://doi.org/10.1158/0008-5472.c.6499713.v1