Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Stefan Klein-Heßling"'
Autor:
Sabrina Giampaolo, Cristina M. Chiarolla, Konrad Knöpper, Martin Vaeth, Matthias Klein, Azeem Muhammad, Tobias Bopp, Friederike Berberich-Siebelt, Amiya K. Patra, Edgar Serfling, Stefan Klein-Hessling
Publikováno v:
iScience, Vol 26, Iss 3, Pp 106234- (2023)
Summary: In thymus, the ablation of T cell receptor (TCR)-activated transcription factor NFATc1 or its inducible isoforms during the double-negative (DN) stages of thymocyte development leads to a marked increase in γδ thymocytes whereas the develo
Externí odkaz:
https://doaj.org/article/674aa6d2228e4a759cbeb67b1400a61e
Autor:
Anika Koenig, Martin Vaeth, Yin Xiao, Cristina M. Chiarolla, Raghu Erapaneedi, Matthias Klein, Lena Dietz, Nadine Hundhausen, Snigdha Majumder, Felix Schuessler, Tobias Bopp, Stefan Klein-Hessling, Andreas Rosenwald, Ingolf Berberich, Friederike Berberich-Siebelt
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
CD4+CXCR5+Foxp3+ T-follicular regulatory (TFR) cells control the germinal center responses. Like T-follicular helper cells, they express high levels of Nuclear Factor of Activated T-cells c1, predominantly its short isoform NFATc1/αA. Ablation of NF
Externí odkaz:
https://doaj.org/article/2abac50c221949b989cc5a8fa7379943
Autor:
Khalid Muhammad, Delicia Xavier, Stefan Klein-Hessling, Muhammad Azeem, Tabea Rauschenberger, Krisna Murti, Andris Avots, Matthias Goebeler, Matthias Klein, Tobias Bopp, Malte Sielaff, Stefan Tenzer, Sigrid Möckel, José Aramburu, Cristina López-Rodríguez, Andreas Kerstan, Edgar Serfling
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
The skin protects the human body against dehydration and harmful challenges. Keratinocytes (KCs) are the most abundant epidermal cells, and it is anticipated that KC-mediated transport of Na+ ions creates a physiological barrier of high osmolality ag
Externí odkaz:
https://doaj.org/article/19aad1d646c04b418caa26fa475c93ec
Publikováno v:
Cells, Vol 11, Iss 13, p 2012 (2022)
Hematopoietic stem and progenitor cell (HSPC) maintenance and the differentiation of various lineages is a highly complex but precisely regulated process. Multiple signaling pathways and an array of transcription factors influence HSPC maintenance an
Externí odkaz:
https://doaj.org/article/33571ebe629e48daaf126a84fbcac8e3
Autor:
Stefan Klein-Hessling, Khalid Muhammad, Matthias Klein, Tobias Pusch, Ronald Rudolf, Jessica Flöter, Musga Qureischi, Andreas Beilhack, Martin Vaeth, Carsten Kummerow, Christian Backes, Rouven Schoppmeyer, Ulrike Hahn, Markus Hoth, Tobias Bopp, Friederike Berberich-Siebelt, Amiya Patra, Andris Avots, Nora Müller, Almut Schulze, Edgar Serfling
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
NFAT nuclear translocation has been shown to be required for CD8+ T cell cytokine production in response to viral infection. Here the authors show NFATc1 controls the cytotoxicity and metabolic switching of activated CD8+ T cells required for optimal
Externí odkaz:
https://doaj.org/article/3b7e704afb8e41c391e25990abf690c1
Autor:
Tabea Rauschenberger, Viola Schmitt, Muhammad Azeem, Stefan Klein-Hessling, Krisna Murti, Franziska Grän, Matthias Goebeler, Andreas Kerstan, Matthias Klein, Tobias Bopp, Edgar Serfling, Khalid Muhammad
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The massive infiltration of lymphocytes into the skin is a hallmark of numerous human skin disorders. By co-culturing murine keratinocytes with splenic T cells we demonstrate here that T cells affect and control the synthesis and secretion of chemoki
Externí odkaz:
https://doaj.org/article/d3a5c8aa059448ef886b734bfd732357
Autor:
Stefan Klein-Hessling, Ronald Rudolf, Khalid Muhammad, Klaus-Peter Knobeloch, Muhammad Ahmad Maqbool, Pierre Cauchy, Jean-Christophe Andrau, Andris Avots, Claudio Talora, Volker Ellenrieder, Isabella Screpanti, Edgar Serfling, Amiya Kumar Patra
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles
Externí odkaz:
https://doaj.org/article/3f649647fbdd4d0799d4dc0597425c49
Autor:
Hani Alrefai, Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Amiya K. Patra, Andris Avots, Valesca Bukur, Ugur Sahin, Stefan Tenzer, Matthias Goebeler, Andreas Kerstan, Edgar Serfling
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Regulatory B cells are important for preventing skin autoimmunity. Here the authors show that NFATc1 suppresses IL-10 transcription in regulatory B cells, and inhibiting NFATc1 decreases immunopathology in a mouse model of imiquimod-induced skin infl
Externí odkaz:
https://doaj.org/article/2e83ccefff114a268fe56783c1489f9c
Autor:
Johannes Baur, Christoph Otto, Ulrich Steger, Stefan Klein-Hessling, Khalid Muhammad, Tobias Pusch, Krisna Murti, Rhoda Wismer, Christoph-Thomas Germer, Ingo Klein, Nora Müller, Edgar Serfling, Andris Avots
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
The immune suppressants cyclosporin A (CsA) and tacrolimus (FK506) are used worldwide in transplantation medicine to suppress graft rejection. Both CsA and FK506 inhibit the phosphatase calcineurin (CN) whose activity controls the immune receptor-med
Externí odkaz:
https://doaj.org/article/eb6dfbe4c8154dddb41e4bd4dde58bb0
Autor:
Khalid Muhammad, Ronald Rudolf, Duong Anh Thuy Pham, Stefan Klein-Hessling, Katsuyoshi Takata, Nobuko Matsushita, Volker Ellenrieder, Eisaku Kondo, Edgar Serfling
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
In lymphocytes, immune receptor signals induce the rapid nuclear translocation of preformed cytosolic NFAT proteins. Along with co-stimulatory signals, persistent immune receptor signals lead to high levels of NFATc1/αA, a short NFATc1 isoform, in e
Externí odkaz:
https://doaj.org/article/432a5935fbe44384b2ba73958dded5f3