Výsledky vyhledávání - "Stefan K. Drexler"

Akademický článek

Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β

Autor: Mary-Anne Hartley, Remzi O. Eren, Matteo Rossi, Florence Prevel, Patrik Castiglioni, Nathalie Isorce, Chantal Desponds, Lon-Fye Lye, Stephen M. Beverley, Stefan K. Drexler, Nicolas Fasel

Publikováno v: Microbial Cell, Vol 5, Iss 3, Pp 137-149 (2018)

The various symptomatic outcomes of cutaneous leishmaniasis relates to the type and potency of its underlying inflammatory responses. Presence of the cytoplasmic Leishmania RNA virus-1 (LRV1) within Leishmania guyanensis, worsens lesional inflammatio

Externí odkaz: https://doaj.org/article/e33ea0e1fd6742d9b5383788c99607e2

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ASC Speck Formation after Inflammasome Activation in Primary Human Keratinocytes

Autor: Stefan K. Drexler, Amir S. Yazdi, Marc Burian, Martin Röcken, Nikola Smatlik

Publikováno v: Oxidative Medicine and Cellular Longevity
Oxidative Medicine and Cellular Longevity, Vol 2021 (2021)
Oxidative medicine and cellular longevity 2021, 7914829 (2021). doi:10.1155/2021/7914829 special issue: "Role of ROS-Induced NLRP3 Inflammasome Activation in Chronic Diseases and Conditions / Edited by: Tao Zheng, Lead Editor; Fang Bian, Guest Editor; Juyi Li, Guest Editor; Francesca Danesi, Guest Editor"

Oxidative medicine and cellular longevity 2021, 7914829 (2021). doi:10.1155/2021/7914829 special issue: "Role of ROS-Induced NLRP3 Inflammasome Activation in Chronic Diseases and Conditions / Edited by: Tao Zheng, Lead Editor; Fang Bian, Guest Editor

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92cd50c42369202dac9f6bb794e88e66
http://europepmc.org/articles/PMC8589508

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Mammalian Innate Immune Response to a Leishmania-Resident RNA Virus Increases Macrophage Survival to Promote Parasite Persistence

Autor: Lon-Fye Lye, Mary-Anne Hartley, Remzi Onur Eren, Stefan K. Drexler, Florence Prevel, Patrik Castiglioni, Catherine Ronet, Marta Reverte, Matteo Rossi, Stephen M. Beverley, Nicolas Fasel, Ricardo Martin, Walter Reith, Chantal Desponds

Publikováno v: Cell host & microbe
Cell Host and Microbe
Cell host & microbe, vol. 20, no. 3, pp. 318-328
Cell Host & Microbe, Vol. 20, No 3 (2016) pp. 318-328

Some strains of the protozoan parasite Leishmania guyanensis (L.g) harbor a viral endosymbiont called Leishmania RNA virus 1 (LRV1). LRV1 recognition by TLR-3 increases parasite burden and lesion swelling in vivo. However, the mechanisms by which ant

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b1ef29cccf39f145186a18d38ba877ff
http://www.sciencedirect.com/science/article/pii/S1931312816303456

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Leishmania guyanensis parasites block the activation of the inflammasome by inhibiting maturation of IL-1β

Autor: Patrik Castiglioni, Lon-Fye Lye, Mary-Anne Hartley, Chantal Desponds, Nicolas Fasel, Stefan K. Drexler, Florence Prevel, Nathalie Isorce, Stephen M. Beverley, Matteo Rossi, Remzi Onur Eren

Publikováno v: Microbial Cell, vol. 5, no. 3, pp. 137-149
Microbial Cell, Vol 5, Iss 3, Pp 137-149 (2018)
Microbial Cell

The various symptomatic outcomes of cutaneous leishmaniasis relates to the type and potency of its underlying inflammatory responses. Presence of the cytoplasmic javax.xml.bind.JAXBElement@52daeaa2 RNA virus-1 (LRV1) within javax.xml.bind.JAXBElement

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eeecfcf1d91c124b63862af0334d1e7
https://serval.unil.ch/resource/serval:BIB_7AE1E45D5F8B.P001/REF.pdf

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The immunological, environmental, and phylogenetic perpetrators of metastatic leishmaniasis

Autor: Mary-Anne Hartley, Catherine Ronet, Nicolas Fasel, Stephen M. Beverley, Stefan K. Drexler

Publikováno v: Trends in Parasitology
Trends in Parasitology, vol. 30, no. 8, pp. 412-422

Cutaneous leishmaniases have persisted for centuries as chronically disfiguring parasitic infections affecting millions of people across the subtropics. Symptoms range from the more prevalent single, self-healing cutaneous lesion to a persistent, met

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df110dfd5591992c4af6e29d55365a97
https://doi.org/10.1016/j.pt.2014.05.006

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Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

Autor: Stefan K. Drexler, Gertraud Orend, Masahide Kashiwagi, Brian M. J. Foxwell, Nidhi Sofat, Kim S. Midwood, Anna M. Piccinini, Fionula M. Brennan, Annette Trebaul, Julia J. Inglis, Sandra Sacre, Emma Chan

Although there have been major advances in the treatment of rheumatoid arthritis with the advent of biological agents, the mechanisms that drive cytokine production and sustain disease chronicity remain unknown. Tenascin-C (encoded by Tnc) is an extr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e48423056d64128ee92e3cbde0848d11
https://ora.ox.ac.uk/objects/uuid:ebf9d5c3-59db-45a1-bb51-3977370733e4

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Investigating the Function of Coronin A in the Early Starvation Response of Dictyostelium discoideum by Aggregation Assays

Autor: Francesco Brogna, Jean Pieters, Stefan K Drexler, Adrien F. Vinet

Publikováno v: Journal of Visualized Experiments.

Dictyostelium discoideum amoeba are found in soil, feeding on bacteria. When food sources become scarce, they secrete factors to initiate a multicellular development program, during which single cells chemotax towards aggregation centers(1-4). This p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d51b27d5307bfc7c9aec9ad4ad5f572
https://doi.org/10.3791/53972-v

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Silencing of ASC in Cutaneous Squamous Cell Carcinoma

Autor: Karine Lefort, Katharina Meier, Stefan K. Drexler, Amir S. Yazdi, Franziska C. Eberle

Publikováno v: PLoS ONE, Vol 11, Iss 10, p e0164742 (2016)
PLoS ONE
PLoS One, vol. 11, no. 10, pp. e0164742

Apoptosis-associated speck-like protein containing a caspase recruitment domain (ASC) is an important adaptor protein for inflammasome activation, mediating the secretion of protumorigenic innate cytokines. However, ASC is also known to trigger apopt

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a27454bc236f1dca0e3b8dd062f5887
http://europepmc.org/articles/PMC5074456?pdf=render

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Regulation of interleukin 1α secretion by inflammasomes: Table 1

Autor: Stefan K. Drexler, Amir S. Yazdi

Publikováno v: Annals of the Rheumatic Diseases. 72:ii96-ii99

The crucial role of the proinflammatory cytokine interleukin 1β (IL-1β) in driving inflammatory disorders, such as Muckle-Wells syndrome and gout, has been extensively characterised. Owing to its high potency to induce inflammation the activation a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1be8887ed3d286a0152f56ad427f5ac6
https://doi.org/10.1136/annrheumdis-2012-202252

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Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis

Autor: Luca Bonsignore, Mark Masin, Jürg Tschopp, Heiko Hermeking, Amir S. Yazdi, Rene Jackstadt, Stefan K. Drexler, Aubry Tardivel, Pascal Schneider, Olaf Gross

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

A chronic inflammatory microenvironment favors tumor progression through molecular mechanisms that are still incompletely defined. In inflammation-induced skin cancers, IL-1 receptor- or caspase-1–deficient mice, or mice specifically deficient for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d31f08d77e3539e82eb3203e9e3697db
https://doi.org/10.1073/pnas.1209171109

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