Zobrazeno 1 - 10
of 302
pro vyhledávání: '"Stefan K. Bohlander"'
Autor:
Peter Truong, Sylvie Shen, Swapna Joshi, Md Imtiazul Islam, Ling Zhong, Mark J. Raftery, Ali Afrasiabi, Hamid Alinejad-Rokny, Mary Nguyen, Xiaoheng Zou, Golam Sarower Bhuyan, Chowdhury H. Sarowar, Elaheh S. Ghodousi, Olivia Stonehouse, Sara Mohamed, Cara E. Toscan, Patrick Connerty, Purvi M. Kakadia, Stefan K. Bohlander, Katharine A. Michie, Jonas Larsson, Richard B. Lock, Carl R. Walkley, Julie A. I. Thoms, Christopher J. Jolly, John E. Pimanda
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Hypomethylating agents (HMAs) are frontline therapies for Myelodysplastic Neoplasms (MDS) and Acute Myeloid Leukemia (AML). However, acquired resistance and treatment failure are commonplace. To address this, we perform a genome-wide CRISPR-
Externí odkaz:
https://doaj.org/article/73815292edce4c1d9476e3fd55ac41f7
Autor:
Robyn Lints, Christina A. Walker, Omid Delfi, Matthew Prouse, Mandy PohLui De Silva, Stefan K. Bohlander, Andrew C. Wood
Publikováno v:
Biology Open, Vol 13, Iss 9 (2024)
Externí odkaz:
https://doaj.org/article/153047675ef2422ea69c6e5dbe53dcc5
Autor:
Stephen M.F. Jamieson, Peter Tsai, Maria K. Kondratyev, Pratha Budhani, Arthur Liu, Neil N. Senzer, E. Gabriela Chiorean, Shadia I. Jalal, John J. Nemunaitis, Dennis Kee, Avik Shome, Way W. Wong, Dan Li, Nooriyah Poonawala-Lohani, Purvi M. Kakadia, Nicholas S. Knowlton, Courtney R.H. Lynch, Cho R. Hong, Tet Woo Lee, Reidar A. Grénman, Laura Caporiccio, Trevor D. McKee, Mark Zaidi, Sehrish Butt, Andrew M.J. Macann, Nicholas P. McIvor, John M. Chaplin, Kevin O. Hicks, Stefan K. Bohlander, Bradly G. Wouters, Charles P. Hart, Cristin G. Print, William R. Wilson, Michael A. Curran, Francis W. Hunter
Publikováno v:
JCI Insight, Vol 8, Iss 4 (2023)
Externí odkaz:
https://doaj.org/article/b8265d5c0ed44e2583f6823d2b9a7cc0
Autor:
Brianna J. Klein, Anagha Deshpande, Khan L. Cox, Fan Xuan, Mohamad Zandian, Karina Barbosa, Sujita Khanal, Qiong Tong, Yi Zhang, Pan Zhang, Amit Sinha, Stefan K. Bohlander, Xiaobing Shi, Hong Wen, Michael G. Poirier, Aniruddha J. Deshpande, Tatiana G. Kutateladze
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Chromosomal translocations involving the AF10 gene, especially with CALM, are associated with aggressive leukemias. Here the authors show that the PZP domain of AF10, a histone reader, is always excluded/impaired in AF10 fusions, whereas incorporatio
Externí odkaz:
https://doaj.org/article/bc1ee92ef2674d4cb5c121a8d5e098c2
Autor:
Huanhuan Zhao, Jun Lu, Tong Yan, Fei Han, Jie Sun, Xiaolin Yin, Liting Chen, Chao Shen, Mark Wunderlich, Weina Yun, Lingling Yang, Liyun Chen, Dan Su, Stefan K. Bohlander, Fudi Wang, James C. Mulloy, Chong Li, Jianjun Chen, He Huang, Xi Jiang
Publikováno v:
Cell Reports, Vol 38, Iss 4, Pp 110253- (2022)
Summary: Acute myeloid leukemia (AML) is a genetically heterogeneous and frequently fatal malignancy. The ten-eleven translocation (TET)-mediated DNA demethylation is known to be critically associated with AML pathogenesis. Through chemical compound
Externí odkaz:
https://doaj.org/article/b5b81ae881734f6aa8321345573a6fe4
Autor:
Stefan K. Bohlander
Publikováno v:
Haematologica, Vol 105, Iss 1 (2020)
Externí odkaz:
https://doaj.org/article/5343c430e4bc439089b70c2ce6b3c4d6
Autor:
Sebastian Vosberg, Luise Hartmann, Klaus H. Metzeler, Nikola P. Konstandin, Stephanie Schneider, Ashok Varadharajan, Andreas Hauser, Stefan Krebs, Helmut Blum, Stefan K. Bohlander, Wolfgang Hiddemann, Johanna Tischer, Karsten Spiekermann, Philipp A. Greif
Publikováno v:
Haematologica, Vol 103, Iss 12 (2018)
Externí odkaz:
https://doaj.org/article/a594ad57dd074cf5aebd5392af9180f5
Autor:
Luise Hartmann, Sayantanee Dutta, Sabrina Opatz, Sebastian Vosberg, Katrin Reiter, Georg Leubolt, Klaus H. Metzeler, Tobias Herold, Stefanos A. Bamopoulos, Kathrin Bräundl, Evelyn Zellmeier, Bianka Ksienzyk, Nikola P. Konstandin, Stephanie Schneider, Karl-Peter Hopfner, Alexander Graf, Stefan Krebs, Helmut Blum, Jan Moritz Middeke, Friedrich Stölzel, Christian Thiede, Stephan Wolf, Stefan K. Bohlander, Caroline Preiss, Linping Chen-Wichmann, Christian Wichmann, Maria Cristina Sauerland, Thomas Büchner, Wolfgang E. Berdel, Bernhard J. Wörmann, Jan Braess, Wolfgang Hiddemann, Karsten Spiekermann, Philipp A. Greif
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-7 (2016)
The t(8;21) translocation is often found in acute myeloid leukaemia but is not sufficient for development of the disease. In this study, the authors identify frequent mutations in the transcriptional repressor, ZBTB7A, in these patients and show that
Externí odkaz:
https://doaj.org/article/34dfb0d723444cba95f2984a6162b8c6
Autor:
Xi Jiang, Chao Hu, Stephen Arnovitz, Jason Bugno, Miao Yu, Zhixiang Zuo, Ping Chen, Hao Huang, Bryan Ulrich, Sandeep Gurbuxani, Hengyou Weng, Jennifer Strong, Yungui Wang, Yuanyuan Li, Justin Salat, Shenglai Li, Abdel G. Elkahloun, Yang Yang, Mary Beth Neilly, Richard A. Larson, Michelle M. Le Beau, Tobias Herold, Stefan K. Bohlander, Paul P. Liu, Jiwang Zhang, Zejuan Li, Chuan He, Jie Jin, Seungpyo Hong, Jianjun Chen
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-15 (2016)
Mir-22 has been shown to be an oncogenic microRNA in breast cancer and myelodysplastic syndrome. Here, the authors show that mir-22 functions as a tumour suppressor in de novoacute myeloid leukaemia by inhibiting the expression of several oncogenes a
Externí odkaz:
https://doaj.org/article/f6c55704ac9d48718faf67aaba2ba41b
Autor:
Purvi M. Kakadia, Ralf Schmidmaier, Andreas Völkl, Irene Schneider, Natalia Huk, Stephanie Schneider, Gerda Panzner, Ulrike Neidel, Barbara Fritz, Karsten Spiekermann, Stefan K. Bohlander
Publikováno v:
Leukemia Research Reports, Vol 6, Iss C, Pp 50-54 (2016)
We report the case of a 26 year-old patient presenting with a persistent leukocytosis and CML-like marrow but no evidence of a BCR/ABL1 fusion. Molecular cytogenetics revealed that a portion of the ETV6 locus was inserted into the ABL1 locus. An ETV6
Externí odkaz:
https://doaj.org/article/caeaa3d03b4343668966b119e46e9282