Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Stefan Köster"'
Autor:
Pallavi Chandra, Li He, Matthew Zimmerman, Guozhe Yang, Stefan Köster, Mireille Ouimet, Han Wang, Kathyrn J. Moore, Véronique Dartois, Joel D. Schilling, Jennifer A. Philips
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT Macrophage activation involves metabolic reprogramming to support antimicrobial cellular functions. How these metabolic shifts influence the outcome of infection by intracellular pathogens remains incompletely understood. Mycobacterium tuber
Externí odkaz:
https://doaj.org/article/9440bf7fd7254ee79c47ed8d7a264eb2
Autor:
Ekansh Mittal, Michael L. Skowyra, Grace Uwase, Emir Tinaztepe, Alka Mehra, Stefan Köster, Phyllis I. Hanson, Jennifer A. Philips
Publikováno v:
mBio, Vol 9, Iss 6 (2018)
ABSTRACT Intracellular pathogens have varied strategies to breach the endolysosomal barrier so that they can deliver effectors to the host cytosol, access nutrients, replicate in the cytoplasm, and avoid degradation in the lysosome. In the case of My
Externí odkaz:
https://doaj.org/article/c4bdf88233dc4f09936ec76bdaa9891d
Mycobacterium tuberculosis type VII secreted effector EsxH targets host ESCRT to impair trafficking.
Autor:
Alka Mehra, Aleena Zahra, Victor Thompson, Natalie Sirisaengtaksin, Ashley Wells, Maura Porto, Stefan Köster, Kristen Penberthy, Yoshihisha Kubota, Amelie Dricot, Daniel Rogan, Marc Vidal, David E Hill, Andrew J Bean, Jennifer A Philips
Publikováno v:
PLoS Pathogens, Vol 9, Iss 10, p e1003734 (2013)
Mycobacterium tuberculosis (Mtb) disrupts anti-microbial pathways of macrophages, cells that normally kill bacteria. Over 40 years ago, D'Arcy Hart showed that Mtb avoids delivery to lysosomes, but the molecular mechanisms that allow Mtb to elude lys
Externí odkaz:
https://doaj.org/article/8cf2ec156ac647b2b5f8f2e3b35e59d3
Autor:
Heiner Latus, Jana Stammermann, Inga Voges, Birgit Waschulzik, Matthias Gutberlet, Gerhard‐Paul Diller, Dietmar Schranz, Peter Ewert, Philipp Beerbaum, Titus Kühne, Samir Sarikouch, Gunter Kerst, Majed Kanaan, Corinna Lebherz, André Rüffer, Dimitrios Gkalpakiotis, Andrea Schedifka, Gernot Buheitel, Joachim Streble, Rainer Willing, Stephan Schubert, Kai Thorsten Laser, Eugen Sandica, Burkhard Trusen, Felix Berger, Oliver Miera, Stanislav Ovroutski, Katharina Schmitt, Joachim Photiadis, Bernd Opgen‐Rhein, Katja Weiss, Sabine Klaassen, Christoph Berns, Thomas Boeckel, Guido Haverkämper, Andreas Kästner, Heike Koch, Björn Peters, Florian Schmidt, Jens Timme, Konstanze Engel, Birgit Franzbach, Gabriela Senft, Frank Beyer, Klaus Winter, Johannes Breuer, Martin Schneider, Jens Bahlmann, Eberhard Griese, Trong Phi Lê, Joachim Hebe, Jan‐Hendrik Nürnberg, Annette Magsaam, Ronald Müller, Ludger Potthoff, Renate Voigt, Tim Krüger, Hubert Gerleve, Ulrich Kleideiter, Dirk Schneider‐Kulla, Jürgen Krülls‐Münch, Thomas Menke, Martin Lehn, Antje Heilmann, Helge Tomczak, Gleb Tarusinov, Michael Scheid, Ertan Mayatepek, Frank Pillekamp, Artur Lichtenberg, Christiane Terpeluk, Bruno Kolterer, Sven Dittrich, Ulrike Gundlach, Robert Cesnjevar, Carsten Müntjes, Geert Morf, Anoosh Esmaeili, Stephan Backhoff, Brigitte Stiller, Friedhelm Beyersdorf, Johannes Kroll, Nicole Häffner, Jannos Siaplaouras, Antje Masri‐Zada, Christian Jux, Andreas Böning, Hakan Akintürk, Thomas Paul, Matthias Sigler, Theodor Tirilomis, Gabriele Schürer, Johannes Hartmann, Ralph Grabitz, Uta Liebaug, Claudius Rotzsch, Rainer Kozlik‐Feldmann, Carsten Rickers, Thomas Mir, Michael Hübler, Jörg Sachweh, Stefan Renz, Andreas Schemm, Bernd Friedrich, Otmar Schlobohm, Dietmar Böthig, Burkhard Wermter, Andrea Kelter‐Klöpping, Alexander Horke, Johann Bauersachs, Mechthild Westhoff‐Bleck, Matthias Gorenflo, Matthias Karck, Tsvetomir Loukanov, Hermann Schrüfer, Martin Wilken, Hashim Abdul‐Khaliq, Tanja Rädle‐Hurst, Axel Rentzsch, Hans‐Joachim Schäfers, Hagen Reichert, Daniel Vilser, Thomas Kriebel, Arnulf Boysen, Anselm Uebing, Tim Attmann, Joachim Thomas Cremer, Jens Scheewe, Regina Buchholz‐Berdau, Peter Möller, Thorsten Horter, Konrad Brockmeier, Gerardus B. W. E Bennink, Stephan Baldus, Alex Gillor, Tim Niehues, Wolfgang Lawrenz, Steffen Leidig, Ingo Dähnert, Frank‐Thomas Riede, Martin Kostelka, Liane Kändler, Martin Bethge, Stefan Köster, Christoph Schröder, Jens Karstedt, Uwe Seitz, Christoph Kampmann, Daniel‐Sebastian Dohle, Frank Stahl, Mojtaba Abedini, Joachim Müller‐Scholden, Alfred Hager, Michael Huntgeburth, Harald Kaemmerer, Nicole Nagdyman, Jörg Schoetzau, Oktay Tutarel, Rüdiger Lange, Jürgen Hörer, Nikolaus A Haas, Michael Hauser, Alexander Roithmaier, Hans‐Gerd Kehl, Astrid Lammers, Edward Malec, Helmut Baumgartner, Gerhard Diller, Roswitha Bahle, Gerald Hofner, Stefan Zink, Roland Reif, Helmut Singer, Christoph Parlasca, Matthias W Freund, Michael Schumacher, Oliver Dewald, Christine Darrelmann, Olaf Willmann, Norbert Schmiedl, Peter Quick, Dirk Hillebrand, Stephan Michele Eiselt, Torsten Nekarda, Michael Eberhard, Georg Baier, Frank Uhlemann, Ioannis Tzanavaros, Alexander Beyer, Gudrun Binz, Steffen Hess, Thomas Teufel, Ronald‐Peter Handke, Michael Hofbeck, Renate Kaulitz, Ludger Sieverding, Christian Schlensak, Christian Apitz, Michael Kaestner, Jürgen Holtvogt, Carl‐Friedrich Wippermann, Sönke Hinz, Andreas Heusch, Johannes Wirbelauer, Wolfgang Brosi
Publikováno v:
Journal of the American Heart Association. 11
Background Right ventricular outflow tract (RVOT) stenosis after repair of tetralogy of Fallot has been linked with favorable right ventricular remodeling but adverse outcomes. The aim of our study was to assess the hemodynamic impact and prognostic
Autor:
Kathyrn J. Moore, Mireille Ouimet, Matthew C. Zimmerman, Pallavi Chandra, Véronique Dartois, Guozhe Yang, Li He, Jennifer A. Philips, Joel D. Schilling, Stefan Köster, Han Wang
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
mBio
mBio
Mycobacterium tuberculosis (Mtb) is the leading infectious disease killer worldwide. We discovered that intracellular Mtb fails to grow in macrophages in which fatty acid β-oxidation (FAO) is blocked. Macrophages treated with FAO inhibitors rapidly
Autor:
Matthew C. Zimmerman, Jennifer A. Philips, Véronique Dartois, Kathyrn J. Moore, Joel D. Schilling, Mireille Ouimet, Pallavi Chandra, Li He, Han Wang, Stefan Köster, Guozhe Yang
SUMMARYMacrophage activation involves metabolic reprogramming to support antimicrobial cellular functions. How these metabolic shifts influence the outcome of infection by intracellular pathogens remains incompletely understood. M. tuberculosis (Mtb)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff1fa52a3591b561e4183399968b2458
https://doi.org/10.1101/799619
https://doi.org/10.1101/799619
Autor:
Christopher M. Sassetti, K. G. Papavinasasundaram, Thais Klevorn, Stefan Köster, Cynthia Portal-Celhay, Jennifer A. Philips
Publikováno v:
Vaccine. 36:939-944
Development of a new vaccine against tuberculosis is urgently needed. Recent work has demonstrated that two related LC3-associated trafficking pathways, autophagy and LC3-associated phagocytosis (LAP), enhance antigen presentation and might play a ro
Publikováno v:
Autophagy. 14:552-554
M. tuberculosis causes an enormous worldwide burden of disease. Its success depends upon subverting the antimicrobial capacity of macrophages. We have known for decades that M. tuberculosis impairs phagosomal trafficking to avoid lysosomal degradatio
Autor:
Emir Tinaztepe, Stefan Köster, Alka Mehra, Phyllis I. Hanson, Grace Uwase, Ekansh Mittal, Michael L. Skowyra, Jennifer A. Philips
Publikováno v:
mBio, Vol 9, Iss 6, p e01765-18 (2018)
mBio, Vol 9, Iss 6 (2018)
mBio
mBio, Vol 9, Iss 6 (2018)
mBio
Mycobacterium tuberculosis causes tuberculosis, which kills more people than any other infection. M. tuberculosis grows in macrophages, cells that specialize in engulfing and degrading microorganisms. Like many intracellular pathogens, in order to ca
Mycobacterium tuberculosis induces the miR-33 locus to reprogram autophagy and host lipid metabolism
Autor:
Yves L. Marcel, Scott R. Oldebeken, Cynthia Portal-Celhay, Bhama Ramkhelawon, Mireille Ouimet, Kathryn J. Moore, Katey J. Rayner, Katharine Cecchini, Erik T. Sakowski, Jennifer A. Philips, Denuja Karunakaran, Tathagat Dutta Ray, Philip D. Zamore, Stefan Köster, Frederick J. Sheedy, Coen van Solingen
Publikováno v:
Nature immunology
Mycobacterium tuberculosis (Mtb) survives in macrophages by evading delivery to the lysosome and promoting the accumulation of lipid bodies, which serve as a bacterial source of nutrients. We found that by inducing the microRNA (miRNA) miR-33 and its